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- Fugl-Meyer, K. S., et al.
(författare)
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The effect of tadalafil on psychosocial outcomes in Swedish men with erectile distress : a multicentre, non-randomised, open-label clinical study
- 2006
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Ingår i: International journal of clinical practice (Esher). - : Hindawi Limited. - 1368-5031 .- 1742-1241. ; 60:11, s. 1386-1393
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Tidskriftsartikel (refereegranskat)abstract
- A multicentre, non-randomised, open-label study assessed whether personal distress caused by erectile dysfunction (ED) affected psychosocial outcomes of tadalafil treatment. Eligible Swedish men at least 18 years old reporting >= 3-month history of ED were stratified into two groups (manifest or mild/no distress) based upon a distress question administered at enrolment. Tadalafil 20 mg was taken as needed for 8 weeks. The primary outcome was the difference between the two distress groups in change from baseline in the Psychological and Interpersonal Relationship Scales (PAIRS) spontaneity domain. Secondary outcome measures were PAIRS sexual self-confidence and time concerns domains, Life Satisfaction (LiSat-11) checklist and a Global Assessment of Treatment Response. The study also assessed tolerability. Of 662 men enrolled, 88% had manifest distress and 12% had mild/no distress. Baseline-to-endpoint changes for PAIRS domains were not significantly different between groups. Baseline-to-endpoint changes in LiSat-11 items were not significantly different between groups except for satisfaction with sexual life. Compared with men without ED, below normal baseline satisfaction with partner relationship and family life were normalised at endpoint. Over 90% of men reported improved erection and ability to engage in sexual activity. The most common treatment-emergent adverse events were headache, myalgia, dyspepsia, flushing and back pain. One man discontinued because of myalgia; 630 (95%) completed the study. In conclusion, erectile distress levels vary among patients with ED and distress can affect intra-familiar aspects of life, which may have implications for clinical practise. However, distress does not appear to hinder improvement in both mechanical and psychosocial outcomes of tadalafil treatment.
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| 5. |
- Kruljac, M., et al.
(författare)
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Symptoms of sexual dysfunction among men from infertile couples : prevalence and association with testosterone deficiency
- 2020
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Ingår i: Andrology. - : Wiley. - 2047-2919 .- 2047-2927. ; 8:1, s. 160-165
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Tidskriftsartikel (refereegranskat)abstract
- Background: This case control study aimed to investigate whether symptoms of sexual dysfunction are more common in males from infertile couples than in the general population and to explore whether symptoms of sexual dysfunction are associated to hypogonadism. Objectives: Participants were 165 subfertile men in infertile heterosexual relationships, 18–50 years of age, with sperm concentrations < 15 × 106/mL. The controls were 199 men from a population-based group, matched for age. Material and methods: Logistic regression was applied in order to calculate odds ratios (ORs) for seven different symptoms of sexual dysfunction. In a multivariate model, we tested independent effects of infertility and primary as well as secondary hypogonadism. Results: Statistically significant association between subfertility and symptoms of sexual dysfunction was found for lack of ability to control ejaculation (OR 2.2, 95% CI: 1.2–4.2). For hypogonadism, statistical significance was seen both in relation to low sexual interest/desire for sex (OR 2.3, 95% CI: 1.0–5.5) and for being worried about the size or shape of the penis (OR 3.6, 95% CI: 1.3–9.5). These associations remained statistically significant in males with primary but not those with secondary hypogonadism. Discussion: Our study showed that men from infertile couples have an increased risk of symptoms of sexual dysfunction and this risk is linked to androgen deficiency. Conclusion: Assessment of reproductive hormone levels and sexual function should routinely be done in this group of males.
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| 9. |
- Wagner, G, et al.
(författare)
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Symptoms score and quality life
- 2000
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Ingår i: Erectile dysfunction. - : Health Publication Ltd. ; , s. 105-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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