| 1. |
- Eijsbouts, C., et al.
(författare)
-
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
- 2021
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 53:11, s. 1543-1552
-
Tidskriftsartikel (refereegranskat)abstract
- Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain–gut interactions underlying IBS. © 2021, The Author(s).
|
|
| 2. |
|
|
| 3. |
- Gauss, Walter, 1969-, et al.
(författare)
-
The Middle Helladic Large Building Complex at Kolonna. A Preliminary View
- 2011
-
Ingår i: Our Cups are Full: Pottery and Society in the Aegean Bronze Age. - Oxford : Archaeopress. - 9781905739394 ; , s. 76-87
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This paper introduces the so-called Large Building Complex at Kolonna, Aegina for the first time in a comprehensive way. The “Large Building Complex” is the thus far largest building found at Kolonna, except the fortification wall. The Building was constructed at the beginning of the Middle Helladic period (MH I/II) and remained in use until the beginning of the Late Helladic period (LH I/II ). Within its long history, it underwent a series of changes and modifications. Size and dimensions as well as the rich finds from its interior clearly indicate that the “Large Building Complex” is the unambiguous residential building from Middle Helladic Kolonna
|
|
| 4. |
- Lindblom, Michael, 1969-, et al.
(författare)
-
Aeginetan Late Bronze and Early Iron Age cooking pottery
- 2017
-
Ingår i: From Cooking Vessels to Cultural Practices in the Late Bronze Age Aegean. - Oxford and Philadelphia : Oxbow Books. - 9781785706325 - 9781785706332 ; , s. 46-56
-
Bokkapitel (refereegranskat)
|
|
| 5. |
|
|
| 6. |
- Lindblom, Michael, 1969-, et al.
(författare)
-
Some Reflections on Ceramic Technology Transfer at Bronze Age Kastri on Kythera, Kolonna on Aegina, and Lerna in the Argolid
- 2015
-
Ingår i: The Transmission of Technical Knowledge in the Production of Ancient Mediterranean Pottery. - 9783900305789 ; , s. 225-237
-
Konferensbidrag (refereegranskat)abstract
- The introduction of novel ideas and skills in pottery manufacture at the settlements of Kastri, Kolonna, and Lernaare used to illustrate how different potting traditions in the Bronze Age Aegean intersected. The insertion of foreignceramic traits into previously established production environments are discussed as examples of acceptance (Kastri),rejection (Kolonna), and mediation (Lerna) in an attempt to nuance the complex process of ›Minoanization‹ in theAegean Bronze Age.
|
|
| 7. |
|
|
| 8. |
- Wild, Eva-Maria, et al.
(författare)
-
14C dating of the Early to Late Bronze Age stratigraphic sequence of Aegina Kolonna, Greece
- 2010
-
Ingår i: Nuclear Instruments and Methods in Physics Research Section B. - : Elsevier BV. - 0168-583X .- 1872-9584. ; 268:7-8, s. 1013-1021
-
Tidskriftsartikel (refereegranskat)abstract
- Aegina Kolonna, located in the center of the Saronic Gulf in the Aegean Mediterranean (Greece), is one of the major archaeological sites of the Aegean Bronze Age with a continuous stratigraphic settlement sequence from the Late Neolithic to the Late Bronze Age. Due to its position next to the maritime cross roads between central mainland Greece, the northeast Peloponnese, the Cyclades and Crete, the island played an important role in the trade between these regions. In the course of new excavations, which focused on the exploration of the Early, Middle and Late Bronze Age at Kolonna, several short lived samples from different settlement phases have been 14C-dated with the AMS method at the VERA laboratory. Bayesian sequencing of the 14C data according to the stratigraphic position of the samples in the profile was performed to enable estimates of the transition time between the cultural phases. The Aegina Kolonna 14C sequence is one of the longest existing so far for the Aegean Bronze Age, and therefore of major importance for the absolute Bronze Age chronology in this region. Preliminary results indicate that the Middle Helladic period seems to have started earlier and lasted longer than traditionally assumed. Further, at the present stage of our investigation we can give also a very tentative time frame for the Santorini volcanic eruption which seems to be in agreement with the science derived VDL date.
|
|
