| 1. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 2. |
- Barnett, R., et al.
(författare)
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Euclid preparation V. Predicted yield of redshift 7 < z < 9 quasars from the wide survey
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 631
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Tidskriftsartikel (refereegranskat)abstract
- We provide predictions of the yield of 7 < z < 9 quasars from the Euclid wide survey, updating the calculation presented in the Euclid Red Book in several ways. We account for revisions to the Euclid near-infrared filter wavelengths; we adopt steeper rates of decline of the quasar luminosity function (QLF; Phi) with redshift, Phi proportional to 10(k(z-6)), k = 0:72, and a further steeper rate of decline, k = 0:92; we use better models of the contaminating populations (MLT dwarfs and compact early-type galaxies); and we make use of an improved Bayesian selection method, compared to the colour cuts used for the Red Book calculation, allowing the identification of fainter quasars, down to J(AB) similar to 23. Quasars at z > 8 may be selected from Euclid OYJH photometry alone, but selection over the redshift interval 7 < z < 8 is greatly improved by the addition of z-band data from, e.g., Pan-STARRS and LSST. We calculate predicted quasar yields for the assumed values of the rate of decline of the QLF beyond z = 6. If the decline of the QLF accelerates beyond z = 6, with k = 0.92, Euclid should nevertheless find over 100 quasars with 7.0 < z < 7.5, and similar to 25 quasars beyond the current record of z = 7.5, including similar to 8 beyond z = 8.0. The first Euclid quasars at z > 7.5 should be found in the DR1 data release, expected in 2024. It will be possible to determine the bright-end slope of the QLF, 7 < z < 8, M-1450 < 25, using 8m class telescopes to confirm candidates, but follow-up with JWST or E-ELT will be required to measure the faint-end slope. Contamination of the candidate lists is predicted to be modest even at J(AB) similar to 23. The precision with which k can be determined over 7 < z < 8 depends on the value of k, but assuming k = 0.72 it can be measured to a 1 sigma uncertainty of 0.07.
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| 3. |
- Adriani, O., et al.
(författare)
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Latest results from the Pamela experiment
- 2009
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Ingår i: Proceedings of Science. ; , s. 1-6
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Konferensbidrag (refereegranskat)abstract
- In this paper we present the latest results of the Pamela satellite experiment, focusing in particular on the p̄/p and the e +/(e+ +e-) ratios.
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| 4. |
- Koldobskiy, S. A., et al.
(författare)
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Galactic deuteron spectrum measured in PAMELA experiment
- 2013
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Ingår i: 23Rd European Cosmic Ray Symposium (And 32Nd Russian Cosmic Ray Conference). - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- Results of galactic deuteron spectrum measurement by means of PAMELA apparatus are described. PAMELA is an international experiment developed for antimatter search and measurement of p, He, electron and positron spectra in wide energy range. In addition, PAMELA allows to identify and measure deuteron spectrum at low energies. In this paper deuteron-to-proton ratio and deuteron spectrum are presented.
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| 5. |
- Adriani, O., et al.
(författare)
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A statistical procedure for the identification of positrons in the PAMELA experiment
- 2010
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 34:1, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- The PAMELA satellite experiment has measured the cosmic-ray positron fraction between 1.5 GeV and 100 GeV. The need to reliably discriminate between the positron signal and proton background has required the development of an ad hoc analysis procedure. In this paper, a method for positron identification is described and its stability and capability to yield a correct background estimate is shown. The analysis includes new experimental data, the application of three different fitting techniques for the background sample and an estimate of systematic uncertainties due to possible inaccuracies in the background selection. The new experimental results confirm both solar modulation effects on cosmic-rays with low rigidities and an anomalous positron abundance above 10 GeV. (c) 2010 Elsevier B.V. All rights reserved.
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| 6. |
- Adriani, O., et al.
(författare)
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Measurement of the flux of primary cosmic ray antiprotons with energies of 60 MeV to 350 GeV in the PAMELA experiment
- 2013
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Ingår i: JETP Letters. - 0021-3640 .- 1090-6487. ; 96:10, s. 621-627
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Tidskriftsartikel (refereegranskat)abstract
- It is interesting to measure the antiproton galactic component in cosmic rays in order to study the mechanisms by which particles and antiparticles are generated and propagate in the Galaxy and to search for new sources of, e.g., annihilation or decay of dark matter hypothetical particles. The antiproton spectrum and the ratio of the fluxes of primary cosmic ray antiprotons to protons with energies of 60 MeV to 350 GeV found from the data obtained from June 2006 to January 2010 in the PAMELA experiment are presented. The usage of the advanced data processing method based on the data classification mathematical model made it possible to increase statistics and analyze the region of higher energies than in the earlier works.
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| 7. |
- Adriani, O., et al.
(författare)
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Measurements of cosmic-ray proton and helium spectra with the PAMELA calorimeter
- 2013
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Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 219-226
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Tidskriftsartikel (refereegranskat)abstract
- We present a new measurement of the cosmic ray proton and helium spectra by the PAMELA experiment performed using the "thin" (in terms of nuclei interactions) sampling electromagnetic calorimeter. The described method, optimized by using Monte Carlo simulation, beam test and experimental data, allows the spectra to be measured up to 10 TeV, thus extending the PAMELA observational range based on the magnetic spectrometer measurement.
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| 8. |
- Adriani, O., et al.
(författare)
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Measurements of quasi-trapped electron and positron fluxes with PAMELA
- 2009
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114, s. A12218-
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents precise measurements of the differential energy spectra of quasi-trapped secondary electrons and positrons and their ratio between 80 MeV and 10 GeV in the near-equatorial region (altitudes between 350 km and 600 km). Latitudinal dependences of the spectra are analyzed in detail. The results were obtained from July until November 2006 onboard the Resurs-DK satellite by the PAMELA spectrometer, a general purpose cosmic ray detector system built around a permanent magnet spectrometer and a silicon-tungsten calorimeter.
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| 9. |
- Adriani, O., et al.
(författare)
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OBSERVATIONS OF THE 2006 DECEMBER 13 AND 14 SOLAR PARTICLE EVENTS IN THE 80 MeV n(-1)-3 GeV n(-1) RANGE FROM SPACE WITH THE PAMELA DETECTOR
- 2011
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 742:2, s. 102-
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Tidskriftsartikel (refereegranskat)abstract
- We present the space spectrometer PAMELA observations of proton and helium fluxes during the 2006 December 13 and 14 solar particle events. This is the first direct measurement of the solar energetic particles in space with a single instrument in the energy range from similar to 80 MeV n(-1) up to similar to 3 GeV n(-1). For the December 13 event, measured energy spectra of solar protons and helium are compared with results obtained by neutron monitors and other detectors. Our measurements show a spectral behavior different from those derived from the neutron monitor network. No satisfactory analytical fitting was found for the energy spectra. During the first hours of the December 13 event, solar energetic particles spectra were close to the exponential form, demonstrating rather significant temporal evolution. Solar He with energy up to 1 GeV n(-1) was recorded on December 13. For the December 14 event, energy of solar protons reached 600 MeV, whereas the maximum energy of He was below 100 MeV n(-1). The spectra were slightly bent in the lower energy range and preserved their form during the second event. Differences in the particle flux appearance and temporal evolution of these two events may argue for special conditions leading to the acceleration of solar particles up to relativistic energies.
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| 10. |
- Adriani, O., et al.
(författare)
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PAMELA Measurements of Cosmic-Ray Proton and Helium Spectra
- 2011
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 332:6025, s. 69-72
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Tidskriftsartikel (refereegranskat)abstract
- Protons and helium nuclei are the most abundant components of the cosmic radiation. Precise measurements of their fluxes are needed to understand the acceleration and subsequent propagation of cosmic rays in our Galaxy. We report precision measurements of the proton and helium spectra in the rigidity range 1 gigavolt to 1.2 teravolts performed by the satellite-borne experiment PAMELA (payload for antimatter matter exploration and light-nuclei astrophysics). We find that the spectral shapes of these two species are different and cannot be described well by a single power law. These data challenge the current paradigm of cosmic-ray acceleration in supernova remnants followed by diffusive propagation in the Galaxy. More complex processes of acceleration and propagation of cosmic rays are required to explain the spectral structures observed in our data.
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