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- Sen, P, et al.
(författare)
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Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys
- 2023
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Ingår i: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 62:10, s. 3291-3301
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveCOVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys.MethodsThe first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups.ResultsWe analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs – OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs – OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7–10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8–0.97)].ConclusionVaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function.
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- Feldstein, Y. I., et al.
(författare)
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Auroral electrojets and 3D currents in the ionosphere-magnetosphere system
- 2006
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Ingår i: “Physics of Auroral Phenomena”, Proc. XXIX Annual Seminar, Apatity. - : Kola Science Centre, Russian Academy of Science. ; , s. 25-30
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- There are shortly described results of the analysis of variations in the location and intensity of the auroral electrojets during magnetic storms and substorms using a numerical method for estimating the equivalent ionospheric currents based on data from meridian chains of magnetic observatories. It is shown that the westward electrojet adjoins to the polar electrojet located at cusp latitudes in the dayside sector. The association of electrojets with the field-aligned currents (FACs), namely Region 1 FAC and Region 2 FAC is considered. During intense disturbances a Region 3 FAC (accompanied with diffuse electron precipitation from the plasma sheet boundary layer) with the downward current was identified. The analysis of observational data is summarized in terms of 2D time-latitude distribution of electrojets at ionospheric altitudes. The magnetic field sawtooth variations generated during the storm main and early recovery phases are also discussed. To follow 3D currents in the magnetosphereionosphere system a clarified view of interrelated 3D currents and magnetospheric plasma domains is presented.
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- Feldstein, Y. I., et al.
(författare)
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Auroral electrojets and boundaries of plasma domains in the magnetosphere during magnetically disturbed intervals
- 2006
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Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 24:8, s. 2243-2276
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Tidskriftsartikel (refereegranskat)abstract
- We investigate variations in the location and intensity of the auroral electrojets during magnetic storms and substorms using a numerical method for estimating the equivalent ionospheric currents based on data from meridian chains of magnetic observatories. Special attention was paid to the complex structure of the electrojets and their interrelationship with diffuse and discrete particle precipitation and field-aligned currents in the dusk sector. During magnetospheric substorms the eastward electrojet (EE) location in the evening sector changes with local time from cusp latitudes (Phi similar to 77 degrees) during early afternoon to latitudes of diffuse auroral precipitation (Phi similar to 65 degrees) equatorward of the auroral oval before midnight. During the main phase of an intense magnetic storm the eastward currents in the noon-early evening sector adjoin to the cusp at Phi similar to 65 degrees and in the pre-midnight sector are located at subauroral latitude Phi similar to 57 degrees. The westward electrojet (WE) is located along the auroral oval from evening through night to the morning sector and adjoins to the polar electrojet (PE) located at cusp latitudes in the day-side sector. The integrated values of the eastward (westward) equivalent ionospheric current during the intense substorm are similar to 0.5 MA (similar to 1.5 MA), whereas they are 0.7 MA (3.0 MA) during the storm main phase maximum. The latitudes of auroral particle precipitation in the dusk sector are identical with those of both electrojets. The EE in the evening sector is accompanied by particle precipitation mainly from the Alfven layer but also from the near-Earth part of the central plasma sheet. In the lower-latitude part of the EE the field-aligned currents (FACs) flow into the ionosphere (Region 2 FAC), and at its higher-latitude part the FACs flow out of the ionosphere (Region 1 FAC). During intense disturbances, in addition to the Region 2 FAC and the Region 1 FAC, a Region 3 FAC with the downward current was identified. This FAC is accompanied by diffuse electron precipitation from the plasma sheet boundary layer. Actually, the triple system of FAC is observed in the evening sector and, as a consequence, the WE and the EE overlap. The WE in the evening sector comprises only the high-latitude periphery of the plasma precipitation region and corresponds to the Hall current between the Region 1 FAC and Region 3 FAC. During the September 1998 magnetic storm, two velocity bursts (similar to 2-4 km/s) in the magnetospheric convection were observed at the latitudes of particle precipitation from the central plasma sheet and at subauroral latitudes near the ionospheric trough. These kind of bursts are known as subauroral polarization streams (SAPS). In the evening sector the Alfven layer equatorial boundary for precipitating ions is located more equatorward than that for electrons. This may favour northward electric field generation between these boundaries and may cause high speed westward ions drift visualized as SAPS. Meanwhile, high speed ion drifts cover a wider range of latitudes than the distance between the equatorward boundaries of ions and electrons precipitation. To summarize the results obtained a new scheme of 3-D currents in the magnetosphere-ionosphere system and a clarified view of interrelated 3-D currents and magnetospheric plasma domains are proposed.
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- Feldstein, Y I, et al.
(författare)
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Electromagnetic characteristics of the high-latitude ionosphere during the various phases of magnetic substorms
- 1996
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 101:A9, s. 19921-19936
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Tidskriftsartikel (refereegranskat)abstract
- Model calculations of the electrodynamics of the high-latitude ionosphere are compared to measurements made by the Viking satellite during July-August 1986. The model calculations are based on the IZMEM procedure, where the electric field and currents in the ionosphere are given as functions of the interplanetary magnetic field. The events chosen correspond to the growth, the expansion, and the recovery phases of substorms. During the growth and expansion phases the correlation between the model results and the satellite data is rather good. During recovery phase the correlation is not as good. The correlation between modeled and observed quantities suggest that during growth and expansion phase the magnetosphere is mainly directly driven by the solar wind, whereas during recovery phase it is mainly driven by internal processes, i.e., loading-unloading. Best fit is obtained when averaging the measured quantities over a few minutes, which means adjusting the spatial resolution of the measurements to the resolution of the model. Different time delays between the interplanetary magnetic field observations and those of Viking were examined. Best agreement was obtained, not surprisingly, for time delays corresponding to the estimated information transit time from the solar wind spacecraft to the ionosphere.
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