| 1. |
- Golman, Klaes, et al.
(författare)
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13C-angiography.
- 2002
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Ingår i: Academic Radiology. - 1878-4046. ; 9:Suppl 2, s. 507-510
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Bjalkebring, Par, et al.
(författare)
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Helping Out or Helping Yourself? : Volunteering and Life Satisfaction Across the Retirement Transition
- 2021
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Ingår i: Psychology and Aging. - : AMER PSYCHOLOGICAL ASSOC. - 0882-7974 .- 1939-1498. ; 36:1, s. 119-130
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Tidskriftsartikel (refereegranskat)abstract
- It has been suggested that volunteering leads to increases in well-being, particularly in older and retiring adults, and that volunteering could be used as a public health intervention to increase well-being. However, the causal relationship has been questioned. We investigated the association between voluntary work and life satisfaction in a bivariate dual-change score model, using 4 years of longitudinal data from 1,123 participants from the Health, Aging and Retirement Transitions in Sweden (HEARTS) study. Both the frequency of volunteering and the level of life satisfaction increased across the retirement transition. However, baseline life satisfaction and volunteering were only marginally associated. Further, the coupling parameters suggest that higher levels of volunteering were followed by decreases in life satisfaction and that higher levels of life satisfaction were followed by increases in volunteering. These findings suggest that increasing levels of volunteering might not be a fruitful strategy for improving life satisfaction for all older adults-if people engage too much in voluntary work, it might even be detrimental for their life satisfaction. More research is needed to better understand when and for whom increased levels of volunteering might have positive effects on life satisfaction.
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| 3. |
- Bjälkebring, Pär, 1984, et al.
(författare)
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Helping Out or Helping Yourself? Volunteering and Life Satisfaction Across the Retirement Transition : Supplemental Material
- 2021
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Ingår i: Psychology and Aging. - : American Psychological Association (APA). - 0882-7974 .- 1939-1498. ; 36:1, s. 119-130
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Tidskriftsartikel (refereegranskat)abstract
- © 2020 American Psychological Association. It has been suggested that volunteering leads to increases in well-being, particularly in older and retiring adults, and that volunteering could be used as a public health intervention to increase well-being. However, the causal relationship has been questioned. We investigated the association between voluntary work and life satisfaction in a bivariate dual-change score model, using 4 years of longitudinal data from 1,123 participants from the Health, Aging and Retirement Transitions in Sweden (HEARTS) study. Both the frequency of volunteering and the level of life satisfaction increased across the retirement transition. However, baseline life satisfaction and volunteering were only marginally associated. Further, the coupling parameters suggest that higher levels of volunteering were followed by decreases in life satisfaction and that higher levels of life satisfaction were followed by increases in volunteering. These findings suggest that increasing levels of volunteering might not be a fruitful strategy for improving life satisfaction for all older adults-if people engage too much in voluntary work, it might even be detrimental for their life satisfaction. More research is needed to better understand when and for whom increased levels of volunteering might have positive effects on life satisfaction.
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| 4. |
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Böter och fredsköp : Jämtlands och Härjedalens saköreslängder 1601–1645
- 2016
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Ingår i: Historisk tidsskrift. - Östersund : Landsarkivet i Östersund. - 0018-263X .- 1504-2944.
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- This is an edition, with commentary, of a series of judicial accounts for the provinces of Jämtland and Härjedalen, dating from 1601 to 1645. Jämtland and Härjedalen are today parts of Sweden, but belonged to Norway until 1645. During the period in question, Norway was part of the dualistic unitary state of Denmark-Norway. The present accounts were made by the bailiffs serving in Jämtland and Härjedalen. They report fines collected by the bailiffs and the misdeeds people were fined for. The bailiffs were subordinate to the feudal lord residing in Trondheim, who had the right to one sixth of the fines collected. The rest of the fines went, together with the accounts and other revenues and records as well, to the treasury of King Kristian IV in Copenhagen. Today all these records are kept in the national archives of Norway and Sweden. In the introduction, Per Sörlin describes and discusses the contents of the judicial accounts, the criminality they reflect, the social setting, the administration in Jämtland and Härjedalen, along with other subjects. In the main part of the edition all text of the judicial accounts is transcribed. Two lists of so-called ‘fredsköp’ (purchases of peace), i.e. fines for eluding outlawry after the 1611–1613 war against Sweden, are included as appendices. These fines were paid by farmers of Jämtland who were punished by the Danish King for disloyalty during the war. Also included in the edition are an investigation of the feudal lords and bailiffs in charge in Jämtland and Härjedalen 1601–45, indices of place-names and officials, and a word list.
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| 5. |
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| 6. |
- Frankel, Rebecca, et al.
(författare)
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Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid
- 2019
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 2:1
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer’s disease is linked to amyloid β (Aβ) peptide aggregation in the brain, and a detailed understanding of the molecular mechanism of Aβ aggregation may lead to improved diagnostics and therapeutics. While previous studies have been performed in pure buffer, we approach the mechanism in vivo using cerebrospinal fluid (CSF). We investigated the aggregation mechanism of Aβ42 in human CSF through kinetic experiments at several Aβ42 monomer concentrations (0.8–10 µM). The data were subjected to global kinetic analysis and found consistent with an aggregation mechanism involving secondary nucleation of monomers on the fibril surface. A mechanism only including primary nucleation was ruled out. We find that the aggregation process is composed of the same microscopic steps in CSF as in pure buffer, but the rate constant of secondary nucleation is decreased. Most importantly, the autocatalytic amplification of aggregate number through catalysis on the fibril surface is prevalent also in CSF.
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| 7. |
- Giang, Kok Wai, 1984, et al.
(författare)
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Long-Term Risk of Hemorrhagic Stroke in Young Patients With Congenital Heart Disease
- 2018
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Ingår i: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 49:5, s. 1155-1162
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Tidskriftsartikel (refereegranskat)abstract
- Background and Purpose-The risk of ischemic stroke is increased in patients with congenital heart disease (CHD); however, data on the risk of hemorrhagic stroke, including intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), are lacking. Methods-The Swedish Patient Register was used to identify all patients who were born with a diagnosis of CHD between 1970 and 1993. Each patient was compared with 10 randomly selected controls from the general population, matched for age, sex, and county. Follow-up data were collected until December 2011 for both cases and controls. Results-Of 21 982 patients with CHD, 70 developed ICH and 57 developed SAH up to the age of 42 years. CHD patients had more than an 8x higher risk (incidence rate ratio, 8.23; 95% confidence interval, 6-11.2) of developing ICH and almost an 8x higher risk of developing SAH (incidence rate ratio, 7.64; 95% confidence interval, 5.41-10.7) compared with controls. The absolute risk of ICH and SAH was low, with incidence rates of 1.18 and 0.96 cases per 10 000 person-years, respectively. Patients with severe nonconotruncal defects (incidence rate ratio, 16.5; 95% confidence interval, 5.63-51.2) or coarctation of the aorta (incidence rate ratio, 17.3; 95% confidence interval, 6.63-51.8) had the highest relative risk of developing hemorrhagic stroke, with incidence rates of 3.22 and 2.79 cases per 10 000 person-years, respectively. Conclusions-The relative risk of hemorrhagic stroke among children and young adults with CHD was almost 8x higher than that of matched controls from the general population, although the absolute risk was low. The highest risk of ICH and SAH occurred in patients with severe nonconotruncal defects and coarctation of the aorta.
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| 8. |
- Golman, Klaes, et al.
(författare)
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Cardiac metabolism measured noninvasively by hyperpolarized (13)C MRI.
- 2008
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Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 1522-2594 .- 0740-3194. ; 59:5, s. 1005-1013
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Tidskriftsartikel (refereegranskat)abstract
- Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart during an ischemic episode. The left circumflex artery of pigs (4 months, male, 29-34 kg) was occluded for 15 or 45 min followed by 2 hr of reperfusion. Pigs were examined by (13)C chemical shift imaging following intravenous injection of 1-(13)C pyruvate. (13)C chemical shift MR imaging was used in order to visualize the local concentrations of the metabolites. After a 15-min occlusion (no infarct) the bicarbonate signal level in the affected area was reduced (25-44%) compared with the normal myocardium. Alanine signal level was normal. After a 45-min occlusion (infarction) the bicarbonate signal was almost absent (0.2-11%) and the alanine signal was reduced (27-51%). Due to image-folding artifacts the data obtained for lactate were inconclusive. These studies demonstrate that cardiac metabolic imaging with hyperpolarized 1-(13)C-pyruvate is feasible. The changes in concentrations of the metabolites within a minute after injection can be detected and metabolic maps constructed. Magn Reson Med 59:1005-1013, 2008. (c) 2008 Wiley-Liss, Inc.
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| 9. |
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Gårdar och arrenden : Jämtlands och Härjedalens bygsellängder 1601-1645
- 2023
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- Accounts of Lease Entrance Fees for Jämtland and Härjedalen 1601–1645. Edited by Georg Hansson and Olof Holm. With an index of place-names by Karl Göran Eriksson.This is an edition, with commentary, of a series of accounts of lease entrance fees for the provinces of Jämtland and Härjedalen, dating from 1601 to 1645. Jämtland and Härjedalen are today parts of Sweden, but belonged to Norway until 1645. During the period in question, Norway was part of the Danish-Norwegian state.The present accounts were made by the bailiffs serving in Jämtland and Härjedalen. They report an entrance fee called bygsel collected by the bailiffs when they let out crown land and so-called avradsland, i.e. divided parts of the common land, on lease to individuals. The quantity of crown land in Jämtland dramatically increased from about 4% to 69% of all land after the Kalmar War of 1611–13, when most of the farmers in this province lost their land to the Danish-Norwegian King Kristian IV. The bailiffs were subordinate to the feudal lord residing in Trondheim, who had the right to a share of the entrance fees collected. The rest of the entrance fees went, together with the accounts and other revenues and records as well, to the King’s treasury in Copenhagen. Today all these records are kept in the national archives of Sweden and Norway.In the introduction, Olof Holm describes and discusses the contents of the accounts, the lease agreements they deal with, the conditions for the leaseholders, the vast growth of crown land in Jämtland during the period, along with other subjects. In the main part of the edition all text of the bygsel accounts is transcribed. Two appendices are included: 1) excerpts from preserved letters describing leasehold agreements from the period, and 2) testimonies concerning the bailiffs’ collecting of bygsel fees. The book ends with indices of place-names and officials, and a word list.
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| 10. |
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