| 1. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 2. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 3. |
- Brewington, Seth, et al.
(författare)
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Islands of change vs. islands of disaster : Managing pigs and birds in the Anthropocene of the North Atlantic
- 2015
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Ingår i: The Holocene. - : Sage Publications. - 0959-6836 .- 1477-0911. ; 25:10, s. 1676-1684
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Tidskriftsartikel (refereegranskat)abstract
- The offshore islands of the North Atlantic were among some of the last settled places on earth, with humans reaching the Faroes and Iceland in the late Iron Age and Viking period. While older accounts emphasizing deforestation and soil erosion have presented this story of island colonization as yet another social–ecological disaster, recent archaeological and paleoenvironmental research combined with environmental history, environmental humanities, and bioscience is providing a more complex understanding of long-term human ecodynamics in these northern islands. An ongoing interdisciplinary investigation of the management of domestic pigs and wild bird populations in Faroes and Iceland is presented as an example of sustained resource management using local and traditional knowledge to create structures for successful wild fowl management on the millennial scale.
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| 4. |
- Dagerman, Stig, 1923-, et al.
(författare)
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Our Need for Consolation is Insatiable
- 2013
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Ingår i: Little Star: a journal of poetry and prose. - New York. - 2158-5830. ; 5, s. 301-307
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- In 1951 Swedish writer Stig Dagerman wrote an autobiographical essay titled "Our Need for Consolation is Insatiable." It is a remarkable poetic meditation on the life-and-death stakes of the literary imagination from a writer who was likely suffering from an undiagnosed bipolar disorder, fighting for his life through one depressive episode after another. Written when his critical reputation and fame as Sweden’s greatest new literary phenom had been firmly established following a remarkable outpouring of critically acclaimed work in the late 1940s, the essay marked a point in time when the tides had turned for Dagerman, who now struggled with the opposite of this productive streak in the form of a debilitating bout of writer’s block that would eventually contribute to his suicide two years later. "Our Need for Consolation is Insatiable" lays bare the writer’s fragile psyche, not only his faltering ego but his selfless and far from sure-footed ambition to offer something of lasting beauty and meaning to a world indifferent to his very existence. While writing the essay, Dagerman managed to rise temporarily from the depths of his depression and identify the sources of his own consolation and hope in terms that have continued to resonate powerfully with many readers, and fellow writers, over the following 60 years. Originally published in 1952 in the improbable venue of Husmodern (a magazine dedicated to home economics for Swedish housewives, analogous to American magazines like Good Housekeeping or Better Homes and Gardens), the essay was a profound response to a trivial commission from the magazine’s editors, who asked Dagerman to send them “something on the art of living.” The soul- and psyche-searching tour de force that Dagerman composed was not likely what the editors had in mind, but to their credit—and also possibly owing to his celebrity—they published the essay as written. The essay has since been translated into 10 languages and published / reprinted a great many times. This is the first literary translation of the essay into English.
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| 5. |
- Dagerman, Stig, 1923-, et al.
(författare)
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Sleet: Selected Stories by Stig Dagerman : Translated from the Swedish by Steven Hartman, with a preface by Alice McDermott
- 2013. - 1st
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Bok (refereegranskat)abstract
- Stig Dagerman (1923–1954) was regarded as the most talented young writer of the Swedish post-war generation. By the 1940s, his fiction, plays, and journalism had catapulted him to the forefront of Swedish letters, with critics comparing him to William Faulkner, Franz Kafka, and Albert Camus. His suicide at the age of thirty-one was a national tragedy. This selection, containing a number of new translations of Dagerman's stories never before published in English, is unified by the theme of the death of innocence. Often narrated from a child's perspective, the stories give voice to childhood's tender state of receptiveness and joy tinged with longing and loneliness.
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| 6. |
- Dagerman, Stig, 1923-, et al.
(författare)
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"The Stockholm Car"
- 2013
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Ingår i: Agni Magazine. - Boston, Mass. USA : Boston University. - 0191-3352.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- English translation of short story by Swedish author Stig Dagerman (1923-1954) about impoverished children in Depression-Era rural Sweden and the shame of being invisible.
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| 10. |
- Hartman, Steven, 1965-
(författare)
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'Civil Disobedience' and Thoreau's 'Utopia of One'
- 2005
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Ingår i: Biennial Conference of the Nordic Association of American Studies, Växjö University, 27 May 2005.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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