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- Labit, B., et al.
(författare)
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Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:8
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Tidskriftsartikel (refereegranskat)abstract
- © 2019 Institute of Physics Publishing. All rights reserved. Within the EUROfusion MST1 work package, a series of experiments has been conducted on AUG and TCV devices to disentangle the role of plasma fueling and plasma shape for the onset of small ELM regimes. On both devices, small ELM regimes with high confinement are achieved if and only if two conditions are fulfilled at the same time. Firstly, the plasma density at the separatrix must be large enough (ne,sep/nG ∼ 0.3), leading to a pressure profile flattening at the separatrix, which stabilizes type-I ELMs. Secondly, the magnetic configuration has to be close to a double null (DN), leading to a reduction of the magnetic shear in the extreme vicinity of the separatrix. As a consequence, its stabilizing effect on ballooning modes is weakened.
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- Hoelzl, M., et al.
(författare)
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Insights into type-I edge localized modes and edge localized mode control from JOREK non-linear magneto-hydrodynamic simulations
- 2018
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Ingår i: Contributions to Plasma Physics. - : Wiley-VCH Verlagsgesellschaft. - 0863-1042 .- 1521-3986. ; 58:6-8, s. 518-528
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Tidskriftsartikel (refereegranskat)abstract
- Edge localized modes (ELMs) are repetitive instabilities driven by the large pressure gradients and current densities in the edge of H-mode plasmas. Type-I ELMs lead to a fast collapse of the H-mode pedestal within several hundred microseconds to a few milliseconds. Localized transient heat fluxes to divertor targets are expected to exceed tolerable limits for ITER, requiring advanced insights into ELM physics and applicable mitigation methods. This paper describes how non-linear magneto-hydrodynamic (MHD) simulations can contribute to this effort. The JOREK code is introduced, which allows the study of large-scale plasma instabilities in tokamak X-point plasmas covering the main plasma, the scrape-off layer, and the divertor region with its finite element grid. We review key physics relevant for type-I ELMs and show to what extent JOREK simulations agree with experiments and help reveal the underlying mechanisms. Simulations and experimental findings are compared in many respects for type-I ELMs in ASDEX Upgrade. The role of plasma flows and non-linear mode coupling for the spatial and temporal structure of ELMs is emphasized, and the loss mechanisms are discussed. An overview of recent ELM-related research using JOREK is given, including ELM crashes, ELM-free regimes, ELM pacing by pellets and magnetic kicks, and mitigation or suppression by resonant magnetic perturbation coils (RMPs). Simulations of ELMs and ELM control methods agree in many respects with experimental observations from various tokamak experiments. On this basis, predictive simulations become more and more feasible. A brief outlook is given, showing the main priorities for further research in the field of ELM physics and further developments necessary.
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- Pamela, S. J. P., et al.
(författare)
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Recent progress in the quantitative validation of JOREK simulations of ELMs in JET
- 2017
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Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 57:7
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Tidskriftsartikel (refereegranskat)abstract
- Future devices like JT-60SA, ITER and DEMO require quantitative predictions of pedestal density and temperature levels, as well as inter-ELM and ELM divertor heat fluxes, in order to improve global confinement capabilities while preventing divertor erosion/melting in the planning of future experiments. Such predictions can be obtained from dedicated pedestal models like EPED, and from non-linear MHD codes like JOREK, for which systematic validation against current experiments is necessary. In this paper, we show progress in the quantitative validation of the JOREK code using JET simulations. Results analyse the impact of diamagnetic terms on the dynamics and size of the ELMs, and evidence is provided that the onset of type-I ELMs is not governed by linear MHD stability alone, but that a nonlinear threshold could be responsible for large MHD events at the plasma edge.
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| 6. |
- Schuster, C, et al.
(författare)
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The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas
- 2011
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 118:17, s. 4635-4645
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Tidskriftsartikel (refereegranskat)abstract
- In Eμ-myc transgenic animals lymphoma formation requires additional genetic alterations, which frequently comprise loss of p53 or overexpression of BCL-2. We describe that the nature of the “second hit” affects the ability of the immune system to contain lymphoma development. Tumors with disrupted p53 signaling killed the host more rapidly than BCL-2 overexpressing ones. Relaxing immunologic control, using Tyk2−/− mice or by Ab-mediated depletion of CD8+ T or natural killer (NK) cells accelerated formation of BCL-2–overexpressing lymphomas but not of those lacking p53. Most strikingly, enforced expression of BCL-2 prolonged disease latency in the absence of p53, whereas blocking p53 function in BCL-2–overexpressing tumors failed to accelerate disease. This shows that blocking apoptosis in p53-deficient cells by enforcing BCL-2 expression can mitigate disease progression increasing the “immunologic visibility.” In vitro cytotoxicity assays confirmed that high expression of BCL-2 protein facilitates NK and T cell–mediated killing. Moreover, we found that high BCL-2 expression is accompanied by significantly increased levels of the NKG2D ligand MULT1, which may account for the enhanced killing. Our findings provide first evidence that the nature of the second hit affects tumor immunosurveillance in c-MYC–driven lymphomas and define a potential shortcoming of antitumor therapies targeting BCL-2.
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