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- Mohammad, Aladdin, et al.
(författare)
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Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss).
- 2016
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 75:2, s. 396-401
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Tidskriftsartikel (refereegranskat)abstract
- Conventional treatment of eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss) with glucocorticoids, with or without additional immunosuppressive drugs, is limited by partial efficacy, frequent toxicity and a high relapse rate. Rituximab is a licensed treatment for granulomatosis with polyangiitis and microscopic polyangiitis and is of potential benefit to patients with EGPA.
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- Klein-Koerkamp, Yanica, et al.
(författare)
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Amygdalar atrophy in early Alzheimer's disease
- 2014
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Ingår i: Current Alzheimer Research. - : Bentham Science Publishers Ltd.. - 1567-2050 .- 1875-5828. ; 11:3, s. 239-252
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Tidskriftsartikel (refereegranskat)abstract
- Current research suggests that amygdalar volumes in patients with Alzheimer's disease (AD) may be a relevant measure for its early diagnosis. However, findings are still inconclusive and controversial, partly because studies did not focus on the earliest stage of the disease. In this study, we measured amygdalar atrophy in 48 AD patients and 82 healthy controls (HC) by using a multi-atlas procedure, MAPER. Both hippocampal and amygdalar volumes, normalized by intracranial volume, were significantly reduced in AD compared with HC. The volume loss in the two structures was of similar magnitude (~24%). Amygdalar volume loss in AD predicted memory impairment after we controlled for age, gender, education, and, more important, hippocampal volume, indicating that memory decline correlates with amygdalar atrophy over and above hippocampal atrophy. Amygdalar volume may thus be as useful as hippocampal volume for the diagnosis of early AD. In addition, it could be an independent marker of cognitive decline. The role of the amygdala in AD should be reconsidered to guide further research and clinical practice. © 2014 Bentham Science Publishers.
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- Sahlberg, A. L., et al.
(författare)
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Non-intrusive, in situ detection of ammonia in hot gas flows with mid-infrared degenerate four-wave mixing at 2.3μm
- 2016
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Ingår i: Journal of Raman Spectroscopy. - : Wiley. - 0377-0486. ; 47:9, s. 1140-1148
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate non-intrusive, in situ detection of ammonia (NH3) in reactive hot gas flows at atmospheric pressure using mid-infrared degenerate four-wave mixing (IR-DFWM). IR-DFWM excitation scans were performed in the v2+v3 and v1+v2 vibrational bands of NH3 around 2.3μm for gas flow temperatures of 296, 550 and 820K. Simulations based on spectroscopic parameters from the HITRAN database have been compared with the measurements in order to identify the spectral lines, and an absorption spectrum at 296K has also been measured to compare with the IR-DFWM spectra. The signal-to-noise ratio of the IR-DFWM measurement was found to be higher than that of the absorption measurement. Some spectral lines in the measured IR-DFWM and absorption spectra had no matching lines in the HITRAN simulation. The detection limit of NH3 diluted in N2 with IR-DFWM in this spectral range was estimated at 296, 550 and 820K to be 1.36, 4.87 and 7.06×1016molecules/cm3. The dependence of the NH3 IR-DFWM signal on the quenching properties of the buffer gas flow was investigated by comparing the signals for gas flows of N2, Ar and CO2 with small admixtures of NH3. It was found that the signal dependence on buffer gas was large at room temperature but decreased at elevated temperatures. These results show the potential of IR-DFWM for detection of NH3 in combustion environments.
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