| 1. |
- Galan, C., et al.
(författare)
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International observational campaigns of the last two eclipses in EE Cephei : 2003 and 2008/9
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 544, s. A53-
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Tidskriftsartikel (refereegranskat)abstract
- Context. EECep is an unusual long-period (5.6 yr) eclipsing binary discovered during the mid-twentieth century. It undergoes almost-grey eclipses that vary in terms of both depth and duration at different epochs. The system consists of a Be type star and a dark dusty disk around an invisible companion. EECep together with the widely studied epsilon Aur are the only two known cases of long-period eclipsing binaries with a dark, dusty disk component responsible for periodic obscurations.Aims. Two observational campaigns were carried out during the eclipses of EECep in 2003 and 2008/9 to verify whether the eclipsing body in the system is indeed a dark disk and to understand the observed changes in the depths and durations of the eclipses.Methods. Multicolour photometric data and spectroscopic observations performed at both low and high resolutions were collected with several dozen instruments located in Europe and North America. We numerically modelled the variations in brightness and colour during the eclipses. We tested models with different disk structure, taking into consideration the inhomogeneous surface brightness of the Be star. We considered the possibility of disk precession.Results. The complete set of observational data collected during the last three eclipses are made available to the astronomical community. The 2003 and 2008/9 eclipses of EECep were very shallow. The latter is the shallowest among all observed. The very high quality photometric data illustrate in detail the colour evolution during the eclipses for the first time. Two blue maxima in the colour indices were detected during these two eclipses, one before and one after the photometric minimum. The first (stronger) blue maximum is simultaneous with a "bump" that is very clear in all the UBV(RI)(C) light curves. A temporary increase in the I-band brightness at the orbital phase similar to 0.2 was observed after each of the last three eclipses. Variations in the spectral line profiles seem to be recurrent during each cycle. The Na I lines always show at least three absorption components during the eclipse minimum and strong absorption is superimposed on the H alpha emission.Conclusions. These observations confirm that the eclipsing object in EECep system is indeed a dark, dusty disk around a low luminosity object. The primary appears to be a rapidly rotating Be star that is strongly darkened at the equator and brightened at the poles. Some of the conclusions of this work require verification in future studies: (i) a complex, possibly multi-ring structure of the disk in EECep; (ii) our explanation of the "bump" observed during the last two eclipses in terms of the different times of obscuration of the hot polar regions of the Be star by the disk; and (iii) our suggested period of the disk precession (similar to 11-12 P-orb) and predicted depth of about 2(m) for the forthcoming eclipse in 2014.
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| 2. |
- Offringa, A. R., et al.
(författare)
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The brightness and spatial distributions of terrestrial radio sources
- 2013
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 435:1, s. 584-596
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Tidskriftsartikel (refereegranskat)abstract
- Faint undetected sources of radio-frequency interference (RFI) might become visible in long radio observations when they are consistently present over time. Thereby, they might obstruct the detection of the weak astronomical signals of interest. This issue is especially important for Epoch of Reionization (EoR) projects that try to detect the faint redshifted H I signals from the time of the earliest structures in the Universe. We explore the RFI situation at 30-163 MHz by studying brightness histograms of visibility data observed with Low-Frequency Array (LOFAR), similar to radio-source-count analyses that are used in cosmology. An empirical RFI distribution model is derived that allows the simulation of RFI in radio observations. The brightness histograms show an RFI distribution that follows a power-law distribution with an estimated exponent around -1.5. With several assumptions, this can be explained with a uniform distribution of terrestrial radio sources whose radiation follows existing propagation models. Extrapolation of the power law implies that the current LOFAR EoR observations should be severely RFI limited if the strength of RFI sources remains strong after time integration. This is in contrast with actual observations, which almost reach the thermal noise and are thought not to be limited by RFI. Therefore, we conclude that it is unlikely that there are undetected RFI sources that will become visible in long observations. Consequently, there is no indication that RFI will prevent an EoR detection with LOFAR.
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| 3. |
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| 4. |
- Paunzen, E., et al.
(författare)
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The first Delta a observations of three globular clusters
- 2014
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 443:3, s. 2492-2498
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Tidskriftsartikel (refereegranskat)abstract
- Globular clusters are main astrophysical laboratories to test and modify evolutionary models. Thought to be rather homogeneous in their local elemental distribution of members, results suggest a wide variety of chemical peculiarities. Besides different main sequences, believed to be caused by different helium abundances, peculiarities of blue horizontal-branch stars and on the red giant branch were found. This whole zoo of peculiar objects has to be explained in the context of stellar formation and evolution. The tool of Delta a photometry is employed in order to detect peculiar stars in the whole spectral range. This three filter narrow-band system measures the flux distribution in the region from 4900 to 5600 angstrom in order to find any peculiarities around 5200 angstrom. It is highly efficient to detect classical chemically peculiar stars of the upper main sequence, Be/Ae, shell and metal-weak objects in the Milky Way and Magellanic Clouds. We present Delta a photometry of 2266 stars from 109 individual frames for three globular clusters (NGC 104, NGC 6205, and NGC 7099). A comparison with published abundances, for three horizontal-branch stars, only, yields an excellent agreement. According to the 3 sigma detection limit of each globular cluster, about 3 per cent of the stars lie in abnormal regions in the diagnostic diagrams. The first observations of three widely different aggregates give very promising results, which will serve as a solid basis for follow-up observations including photometric as well as spectroscopic studies.
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| 5. |
- Asad, K. M. B., et al.
(författare)
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Polarization leakage in epoch of reionization windows - I. Low Frequency Array observations of the 3C196 field
- 2015
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 451:4, s. 3709-3727
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Tidskriftsartikel (refereegranskat)abstract
- Detection of the 21-cm signal coming from the epoch of reionization (EoR) is challenging especially because, even after removing the foregrounds, the residual Stokes I maps contain leakage from polarized emission that can mimic the signal. Here, we discuss the instrumental polarization of Low Frequency Array (LOFAR) and present realistic simulations of the leakages between Stokes parameters. From the LOFAR observations of polarized emission in the 3C196 field, we have quantified the level of polarization leakage caused by the nominal model beam of LOFAR, and compared it with the EoR signal using power spectrum analysis. We found that at 134-166 MHz, within the central 4A degrees of the field the (Q, U) -> I leakage power is lower than the EoR signal at k < 0.3 Mpc(-1). The leakage was found to be localized around a Faraday depth of 0, and the rms of the leakage as a fraction of the rms of the polarized emission was shown to vary between 0.2 and 0.3 per cent, both of which could be utilized in the removal of leakage. Moreover, we could define an 'EoR window' in terms of the polarization leakage in the cylindrical power spectrum above the point spread function (PSF)-induced wedge and below k(ayen) similar to 0.5 Mpc(-1), and the window extended up to k(ayen) similar to 1 Mpc(-1) at all k(aSyen) when 70 per cent of the leakage had been removed. These LOFAR results show that even a modest polarimetric calibration over a field of view of a parts per thousand(2) 4A degrees in the future arrays like Square Kilometre Array will ensure that the polarization leakage remains well below the expected EoR signal at the scales of 0.02-1 Mpc(-1).
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| 6. |
- Bonagas, Nadilly, et al.
(författare)
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
- 2022
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Ingår i: NATURE CANCER. - : Springer Science and Business Media LLC. - 2662-1347. ; 3:2, s. 156-
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Tidskriftsartikel (refereegranskat)abstract
- The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In the present study, we demonstrate a role for MTHFD2 in DNA replication and genomic stability in cancer cells, and perform a drug screen to identify potent and selective nanomolar MTHFD2 inhibitors; protein cocrystal structures demonstrated binding to the active site of MTHFD2 and target engagement. MTHFD2 inhibitors reduced replication fork speed and induced replication stress followed by S-phase arrest and apoptosis of acute myeloid leukemia cells in vitro and in vivo, with a therapeutic window spanning four orders of magnitude compared with nontumorigenic cells. Mechanistically, MTHFD2 inhibitors prevented thymidine production leading to misincorporation of uracil into DNA and replication stress. Overall, these results demonstrate a functional link between MTHFD2-dependent cancer metabolism and replication stress that can be exploited therapeutically with this new class of inhibitors. Helleday and colleagues describe a nanomolar MTHFD2 inhibitor that causes replication stress and DNA damage accumulation in cancer cells via thymidine depletion, demonstrating a potential therapeutic strategy in AML tumors in vivo.
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| 7. |
- Ciardi, B., et al.
(författare)
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Simulating the 21 cm forest detectable with LOFAR and SKA in the spectra of high-z GRBs
- 2015
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 453:1, s. 101-105
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the feasibility of detecting 21 cm absorption features in the afterglow spectra of high redshift long Gamma Ray Bursts (GRBs). This is done employing simulations of cosmic reionization, together with estimates of the GRB radio afterglow flux and the instrumental characteristics of the LOw Frequency ARray (LOFAR). We find that absorption features could be marginally (with a S/N larger than a few) detected by LOFAR at z greater than or similar to 7 if the GRB is a highly energetic event originating from Pop III stars, while the detection would be easier if the noise were reduced by one order of magnitude, i.e. similar to what is expected for the first phase of the Square Kilometre Array (SKA1-low). On the other hand, more standard GRBs are too dim to be detected even with ten times the sensitivity of SKA1-low, and only in the most optimistic case can a S/N larger than a few be reached at z greater than or similar to 9.
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| 8. |
- Evgenieva, Tsvetina, et al.
(författare)
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Three-point observation in the troposphere over Sofia-Plana Mountain,Bulgaria
- 2011
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Ingår i: International Journal of Remote Sensing. - : Informa UK Limited. - 0143-1161 .- 1366-5901. ; 32:24, s. 9343-9363
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Tidskriftsartikel (refereegranskat)abstract
- Based on a novel combination of approaches and instruments, this article presents campaign-based results from atmospheric boundary layer (ABL) height and aerosol optical depth (AOD) measurements carried out at two different experimental sites in Sofia, as well as from three-point measurements of aerosol number concentrations. Several instruments (lidar (developed by the IE), ceilometer, aerosol particle counter, sun photometer and meteorological sensors) were used in this study. Based on joint interpretation of the instruments' data we assess the influence of the atmospheric aerosol in the planetary boundary layer and the significant influence of aerosol layers and high clouds on AOD values. Measurements of AOD in the city basin gave values in the range 0.22-0.41 for cloud-free skies, and up to around 0.8 under partly cloudy conditions. The information obtained during the two campaigns indicates that aerosol particle concentrations were lower in park areas than along heavy-traffic thoroughfares in the city, but higher than in the mountain area. In conclusion, our study demonstrates the potential of employing a broad array of instruments for the study of boundary layer and aerosol over large, valley-situated and heavily urbanized city areas.
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| 9. |
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| 10. |
- Gan, H., et al.
(författare)
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Statistical analysis of the causes of excess variance in the 21 cm signal power spectra obtained with the Low-Frequency Array
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 663
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Tidskriftsartikel (refereegranskat)abstract
- Context. The detection of the 21 cm signal of neutral hydrogen from the Epoch of Reionization (EoR) is challenging due to bright foreground sources, radio frequency interference (RFI), and the ionosphere as well as instrumental effects. Even after correcting for these effects in the calibration step and applying foreground removal techniques, the remaining residuals in the observed 21 cm power spectra are still above the thermal noise, which is referred to as the “excess variance.”Aims. We study a number of potential causes of this excess variance based on 13 nights of data obtained with the Low-Frequency Array (LOFAR).Methods. We focused on the impact of gain errors, the sky model, and ionospheric effects on the excess variance by correlating the relevant parameters such as the gain variance over time or frequency, local sidereal time (LST), diffractive scale, and phase structure–function slope with the level of excess variance.Results. Our analysis shows that the excess variance, at the current level, is neither strongly correlated with gain variance nor the ionospheric parameters. Rather, excess variance has an LST dependence, which is related to the power from the sky. Furthermore, the simulated Stokes I power spectra from bright sources and the excess variance show a similar progression over LST with the minimum power appearing at LST bin 6h to 9h. This LST dependence is also present in sky images of the residual Stokes I of the observations. In very-wide sky images based on one night of observation after direction-dependent calibration, we demonstrate that the extra power comes exactly from the direction of bright and distant sources Cassiopeia A and Cygnus A with the array beam patterns.Conclusions. These results suggest that the level of excess variance in the 21 cm signal power spectra is related to sky effects and, hence, it depends on LST. In particular, very bright and distant sources such as Cassiopeia A and Cygnus A can dominate the effect. This is in line with earlier studies and offers a path forward toward a solution, since the correlation between the sky-related effects and the excess variance is non-negligible.
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