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- Acharya, B. S., et al.
(författare)
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Introducing the CTA concept
- 2013
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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| 3. |
- Bousquet, J, et al.
(författare)
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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
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Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
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Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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| 7. |
- Zuberbier, T., et al.
(författare)
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Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA(2)LEN position paper
- 2022
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Ingår i: Allergy. - : Wiley. - 0105-4538 .- 1398-9995. ; 77:6, s. 1736-1750
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Tidskriftsartikel (refereegranskat)abstract
- Background Food anaphylaxis is commonly elicited by unintentional ingestion of foods containing the allergen above the tolerance threshold level of the individual. While labeling the 14 main allergens used as ingredients in food products is mandatory in the EU, there is no legal definition of declaring potential contaminants. Precautionary allergen labeling such as "may contain traces of" is often used. However, this is unsatisfactory for consumers as they get no information if the contamination is below their personal threshold. In discussions with the food industry and technologists, it was suggested to use a voluntary declaration indicating that all declared contaminants are below a threshold of 0.5 mg protein per 100 g of food. This concentration is known to be below the threshold of most patients, and it can be technically guaranteed in most food production. However, it was also important to assess that in case of accidental ingestion of contaminants below this threshold by highly allergic patients, no fatal anaphylactic reaction could occur. Therefore, we performed a systematic review to assess whether a fatal reaction to 5mg of protein or less has been reported, assuming that a maximum portion size of 1kg of a processed food exceeds any meal and thus gives a sufficient safety margin. Methods MEDLINE and EMBASE were searched until 24 January 2021 for provocation studies and case reports in which one of the 14 major food allergens was reported to elicit fatal or life-threatening anaphylactic reactions and assessed if these occurred below the ingestion of 5mg of protein. A Delphi process was performed to obtain an expert consensus on the results. Results In the 210 studies included, in our search, no reports of fatal anaphylactic reactions reported below 5 mg protein ingested were identified. However, in provocation studies and case reports, severe reactions below 5 mg were reported for the following allergens: eggs, fish, lupin, milk, nuts, peanuts, soy, and sesame seeds. Conclusion Based on the literature studied for this review, it can be stated that cross-contamination of the 14 major food allergens below 0.5 mg/100 g is likely not to endanger most food allergic patients when a standard portion of food is consumed. We propose to use the statement "this product contains the named allergens in the list of ingredients, it may contain traces of other contaminations (to be named, e.g. nut) at concentrations less than 0.5 mg per 100 g of this product" for a voluntary declaration on processed food packages. This level of avoidance of cross-contaminations can be achieved technically for most processed foods, and the statement would be a clear and helpful message to the consumers. However, it is clearly acknowledged that a voluntary declaration is only a first step to a legally binding solution. For this, further research on threshold levels is encouraged.
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| 9. |
- Sissa, E., et al.
(författare)
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High-contrast study of the candidate planets and protoplanetary disk around HD 100546
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 619
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Tidskriftsartikel (refereegranskat)abstract
- The nearby Herbig Be star HD 100546 is known to be a laboratory for the study of protoplanets and their relation with the circum stellar disk, which is carved by at least two gaps. We observed the HD 100546 environment with high-contrast imaging exploiting several different observing modes of SPHERE, including data sets with and without coronagraphs, dual band imaging, integral field spectroscopy and polarimetry. The picture emerging from these different data sets is complex. Flux-conservative algorithm images clearly show the disk up to 200 au. More aggressive algorithms reveal several rings and warped arms that are seen overlapping the main disk. Some of these structures are found to lie at considerable height over the disk mid-plane at about 30 au. Our images demon-strate that the brightest wings close to the star in the near side of the disk are a unique structure, corresponding to the outer edge of the intermediate disk at similar to 40 au. Modeling of the scattered light from the disk with a geometrical algorithm reveals that a moderately thin structure (H/r = 0.18 at 40 au) can well reproduce the light distribution in the flux-conservative images. We suggest that the gap between 44 and 113 au spans between the 1:2 and 3:2 resonance orbits of a massive body located at similar to 70 au, which might coincide with the candidate planet HD 100546b detected with previous thermal infrared (IR) observations. In this picture, the two wings can be the near side of a ring formed by disk material brought out of the disk at the 1:2 resonance with the same massive object. While we find no clear evidence confirming detection of the planet candidate HD 100546c in our data, we find a diffuse emission close to the expected position of HD 100546b. This source can be described as an extremely reddened substellar object surrounded by a dust cloud or its circumplanetary disk. Its astrometry is broadly consistent with a circular orbital motion on the disk plane, a result that could be confirmed with new observations. Further observations at various wavelengths are required to fully understand the complex phenomenology of HD 100546.
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| 10. |
- Bonavita, M., et al.
(författare)
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Orbiting a binary SPHERE characterisation of the HD 284149 system
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 608
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Tidskriftsartikel (refereegranskat)abstract
- Aims. In this paper we present the results of the SPHERE observation of the HD 284149 system, aimed at a more detailed characterisation of both the primary and its brown dwarf companion.Methods. We observed HD 284149 in the near-infrared with SPHERE, using the imaging mode (IRDIS + IFS) and the long-slit spectroscopy mode (IRDIS-LSS). The data were reduced using the dedicated SPHERE pipeline, and algorithms such as PCA and TLOCI were applied to reduce the speckle pattern.Results. The IFS images revealed a previously unknown low-mass (similar to 0.16 M-circle dot) stellar companion (HD 294149 B) at similar to 0.1 '', compatible with previously observed radial velocity differences, as well as proper motion differences between Gaia and Tycho-2 measurements. The known brown dwarf companion (HD 284149 b) is clearly visible in the IRDIS images. This allowed us to refine both its photometry and astrometry. The analysis of the medium resolution IRDIS long slit spectra also allowed a refinement of temperature and spectral type estimates. A full reassessment of the age and distance of the system was also performed, leading to more precise values of both mass and semi-major axis.Conclusions. As a result of this study, HD 284149 ABb therefore becomes the latest addition to the (short) list of brown dwarfs on wide circumbinary orbits, providing new evidence to support recent claims that object in such configuration occur with a similar frequency to wide companions to single stars.
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