| 1. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 2. |
- Arnelid, Maria, et al.
(författare)
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What Does It Mean to Measure a Smile? : Assigning numerical values to emotions
- 2022
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Ingår i: Valuation Studies. - : Linköping University Electronic Press. - 2001-5992. ; 9:1, s. 79-107
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Tidskriftsartikel (refereegranskat)abstract
- This article looks at the implications of emotion recognition, zooming in on the specific case of the care robot Pepper introduced at a hospital in Toronto. Here, emotion recognition comes with the promise of equipping robots with a less tangible, more emotive set of skills – from companionship to encouragement. Through close analysis of a variety of materials related to emotion detection software – iMotions – we look into two aspects of the technology. First, we investigate the how of emotion detection: what does it mean to detect emotions in practice? Second, we reflect on the question of whose emotions are measured, and what the use of care robots can say about the norms and values shaping care practices today. We argue that care robots and emotion detection can be understood as part of a fragmentation of care work: a process in which care is increasingly being understood as a series of discrete tasks rather than as holistic practice. Finally, we draw attention to the multitude of actors whose needs are addressed by Pepper, even while it is being imagined as a care provider for patients.
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| 3. |
- Asplund, Mikael, 1981-, et al.
(författare)
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Integrering av den sociala dimensionen i datautbildningar
- 2019
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Ingår i: Bidrag från 7:e Utvecklingskonferensen för Sveriges ingenjörsutbildningar. - : Luleå: Luleå tekniska universitet. - 9789177906056 ; , s. 189-190
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Björk, Elin, 1981-
(författare)
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Att bota en prostata : Kastrering som behandlingsmetod för prostatahypertrofi 1893-1910
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Avhandlingen behandlar den korta men intensiva perioden 1893–1910 då kastrering användes som behandlingsmetod för att bota prostatahypertrofi. Fokus för analysen är hur prostatan, prostatahypertrofi och testiklarna skapades som medicinska kunskapsobjekt. Studien undersöker även hur jämförelser med andra kroppar – kvinnor, djur, män som avvek från normen med två fungerande testiklar – än den ”normala” manliga kroppen var en viktig del av kunskapsproduktionen av dessa kunskapsobjekt. Analytiskt används främst begreppen agentiell realism, agentiella snitt och vetenskapligt historieberättande. Som ett komplement används även begreppen spektrum och spektrum av avlivningsbarhet för analysen av hur djurs kroppar användes inom medicinen. Analysen visar att andra kroppar än den manliga var viktig för kunskapsproduktionen och att manlig kastrering inte undveks i så stor utsträckning som tidigare forskning har menat. Den kvinnliga kroppen fick även till viss del fungera som ”facit” när det saknades kunskap om den manliga. Analysen visar dessutom att en intra-aktion mellan teori, experiment och klinisk erfarenhet var viktig i den medicinska kunskapsproduktionen.
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| 5. |
- Danemalm Jägervall, Carina, et al.
(författare)
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Gay men’s experiences of sexual changes after prostate cancer treatment : a qualitative study in Sweden
- 2019
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Ingår i: Scandinavian journal of urology. - : Taylor & Francis. - 2168-1805 .- 2168-1813. ; 53:1, s. 40-44
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Tidskriftsartikel (refereegranskat)abstract
- Background: The needs of gay men after prostate cancer treatment are becoming visible. This patient group reports a more negative impact of treatment than heterosexual men. Yet, gay men’s experiences of post-treatment sexual changes are still little explored. This study aims to determine specific concerns of gay men’s post-treatment sexual practices.Methods: A qualitative study design was deployed using semi-structured interviews as data. Participants were purposefully sampled through advertisements and the snowball method. Eleven self-identifying gay men aged 58–81 years and treated for prostate cancer participated in interviews during 2016–2017. The interviews were transcribed, coded and thematically analysed.Results: The analysis highlights sexual changes in relation to the physical body, identity and relations. Problematic physical changes included loss of ejaculate and erectile dysfunction. Some respondents reported continued pleasure from anal stimulation and were uncertain about the role of the prostate. These physical changes prompted reflections on age and (dis)ability. Relationship status also impacted perception of physical changes, with temporary sexual contacts demanding more of the men in terms of erection and ejaculations.Conclusions: Gay prostate cancer survivors’ narratives about sexual changes circle around similar bodily changes as heterosexual men’s, such as erectile problems and weaker orgasms. The loss of ejaculate was experienced as more debilitating for gay men. Men who had anal sex were concerned about penetration difficulties as well as sensations of anal stimulation. Additional studies are required to better understand the role of the prostate among a diversity of men, regardless of sexuality.
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| 6. |
- Dieckmann, Peter, et al.
(författare)
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Bodies in Simulation
- 2019. - 1
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Ingår i: Interprofessional Simulation in Health Care. - Cham : Springer. - 9783030195410 - 9783030195427 ; , s. 175-195
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Bokkapitel (refereegranskat)abstract
- Recent theorisations of practice have suggested that a focus on the role of the body in professional practices, in simulated or naturalistic settings, might enable educators and learners to draw attention to other dimensions of knowledge, which are not easily accessible through cognitive perspectives. Recognising the role of the body in knowledge production in practice goes beyond a focus on the individual practitioner, in the clarification how the performance of a practice is constituted by the relational nature of material arrangements and professional bodies. This chapter re-visits dimensions of simulation from a specific focus of realism and embodiment and discusses the clinical impression of the manikin as multiple bodies being simulated—through doings and sayings bound together with materiality.
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| 7. |
- Dimitrievski, Ivanche, 1988-
(författare)
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Accounting the Future : An Ethnography of the European Spallation Source
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The thesis investigates the social processes involved in the practices of futuring. It addresses the question of how social practices contribute to the production and maintenance of robust versions of the future. It asks how best we should study futurity, including expectations, imaginations, promises and visions. Existing research tells us rather little about how ordinary practices render the future as a particular, publicly available and accountable presence or absence. In what ways do people achieve situated performances of certainty about the future? The thesis addresses these questions by drawing upon recent theoretical themes in Science and Technology Studies (STS), notably accountability relations and mundane practices in science and technology. The empirical focus of the thesis is an extended ethnographic study of the European Spallation Source (ESS) – a major neutron-based science research facility currently under construction in Lund, Sweden. The methods used are a combination of participant observation, interviews, documentary analysis, and ethnomethodologically inflected textual analysis. The thesis reports findings in relation to each of four aspects of ESS work: 1) the textual practices rendering the future of the ESS in local newspaper coverage; 2) documentary analysis of a 2014/2015 Call for ESS Instrument Proposals; 3) observations from visits to ESS and participation in staged “future walks” and 4) the mundane laboratory practices of measuring thickness in an ESS Detector Coatings Workshop in Linköping. The results of these empirical analyses are used to argue for the importance of generating and sustaining accountability relations in futuring practices, for understanding how the future is imagined and made to come about. The thesis concludes that looking at practices in this way has political implications – among other things, it allows to see how agency and capability-to-affect the future is distributed, built, eroded and attributed.
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| 8. |
- Eidenskog, Maria, 1981-, et al.
(författare)
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Changing the world one engineer at a time – unmaking the traditional engineering education when introducing sustainability subjects
- 2023
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Ingår i: International Journal of Sustainability in Higher Education. - : EMERALD GROUP PUBLISHING LTD. - 1467-6370 .- 1758-6739. ; 24:9, s. 70-84
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The information technology (IT) sector has been seen as central to society's transformation to a more just and sustainable society, which underlines teachers’ responsibility to foster engineers who can contribute specifically to such ends. This study aims to report an effort to significantly update an existing engineering programme in IT with this ambition and to analyse the effects and challenges associated with the transformation.Design/methodology/approach: This study is based on a combination of action-oriented research based on implementing key changes to the curriculum; empirical investigations including surveys and interviews with students and teachers, and analysis of these; and a science and technology studies-inspired analysis.Findings: Respondents were generally positive towards adding topics relating to sustainability. However, in the unmaking of traditional engineering subjects, changes created a conflict between core versus soft subjects in which the core subjects tended to gain the upper hand. This conflict can be turned into productive discussions by focusing on what kinds of engineers the authors’ educate and how students can be introduced to societal problems as an integrated part of their education.Practical implications: This study can be helpful for educators in the engineering domain to support them in their efforts to transition from a (narrow) focus on traditional disciplines to one where the bettering of society is at the core.Originality/value: This study provides a novel approach to the transformation of engineering education through a theoretical analysis seldom used in studies of higher education on a novel case study.
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| 9. |
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Gendering Drugs : Feminist Studies of Pharmaceuticals
- 2017
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- This book, by bringing together critical pharmaceutical studies and feminist technoscience studies, explores the way drugs produce sexed and/or gendered identities for those who take – or resist – them, and how feminist technoscience studies can contribute a theoretical lens with which to observe sex and gender in the pharmaceuticalization processes. Topics explored in this diverse collection include the use of hormones to delay puberty onset for trans children; HPV vaccination against cervical cancer in Sweden, the UK, Austria and Colombia; Alzheimer’s discourses; and the medication of prostate issues. Ericka Johnson has brought together an innovative and timely collection that demonstrates gender as relevant in studies of pharmaceuticals, and provides multiple examples of methodological and theoretical tools to consider gender while studying drugs.
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| 10. |
- Gleisner, Jenny, Fil. dr. 1982-, et al.
(författare)
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Approaching distressing or sensitive topics in medical school
- 2021
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Ingår i: Medical Education. - : John Wiley & Sons, Ltd. - 0308-0110 .- 1365-2923. ; 55:11, s. 1221-1222
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The authors encourage a continuous attentiveness to thinking and caring about the challenges medical students will encounter during sensitive discussions.
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