| 1. |
- Hippich, Markus, et al.
(författare)
-
Genetic contribution to the divergence in type 1 diabetes risk between children from the general population and children from affected families
- 2019
-
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 68:4, s. 847-857
-
Tidskriftsartikel (refereegranskat)abstract
- The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-risk HLA genotypes (n = 4,573) in the longitudinal TEDDY birth cohort to determine how much of the divergent risk is attributable to genetic enrichment in affected families. Enrichment for susceptible genotypes of multiple type 1 diabetes–associated genes and a novel risk gene, BTNL2, was identified in FDR children compared with GP children. After correction for genetic enrichment, the risks in the FDR and GP children converged but were not identical for multiple islet autoantibodies (hazard ratio [HR] 2.26 [95% CI 1.6–3.02]) and for diabetes (HR 2.92 [95% CI 2.05–4.16]). Convergence varied depending upon the degree of genetic susceptibility. Risks were similar in the highest genetic susceptibility group for multiple islet autoantibodies (14.3% vs .12.7%) and diabetes (4.8% vs. 4.1%) and were up to 5.8-fold divergent for children in the lowest genetic susceptibility group, decreasing incrementally in GP children but not in FDR children. These findings suggest that additional factors enriched within affected families preferentially increase the risk of autoimmunity and type 1 diabetes in lower genetic susceptibility strata.
|
|
| 2. |
- Holsti, N., et al.
(författare)
-
WCET Tool Challenge 2008 : Report
- 2008
-
Ingår i: OpenAccess Ser. Informatics. - 9783939897101
-
Konferensbidrag (refereegranskat)abstract
- Following the successful WCET Tool Challenge in 2006, the second event in this series was organized in 2008, again with support from the ARTIST2 Network of Excellence. The WCET Tool Challenge 2008 (WCC'08) provides benchmark programs and poses a number of "analysis problems" about the dynamic, runtime properties of these programs. The participants are challenged to solve these problems with their programanalysis tools. Two kinds of problems are defined: WCET problems, which ask for bounds on the execution time of chosen parts (subprograms) of the benchmarks, under given constraints on input data; and flowanalysis problems, which ask for bounds on the number of times certain parts of the benchmark can be executed, again under some constraints. We describe the organization of WCC'08, the benchmark programs, the participating tools, and the general results, successes, and failures. Most participants found WCC'08 to be a useful test of their tools. Unlike the 2006 Challenge, the WCC'08 participants include several tools for the same target (ARM7, LPC2138), and tools that combine measurements and static analysis, as well as pure staticanalysis tools.
|
|
