| 1. |
- Michel, M., et al.
(författare)
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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
- 2022
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Ingår i: Science. - Stockholm : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 376:6600, s. 1471-1476
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Tidskriftsartikel (refereegranskat)abstract
- Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10-fold, and generates a previously undescribed b,d-lyase enzymatic function. TH10785 controls the catalytic activity mediated by a nitrogen base within its molecular structure. In cells, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. This alters the repair process, which no longer requires APE1 but instead is dependent on polynucleotide kinase phosphatase (PNKP1) activity. The increased repair of oxidative DNA lesions with a small molecule may have therapeutic applications in various diseases and aging. © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
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| 2. |
- Jungclaus, A., et al.
(författare)
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New lifetime measurements in the stable semimagic Sn isotopes using the Doppler-shift attenuation technique
- 2011
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 312:SECTION 9
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Tidskriftsartikel (refereegranskat)abstract
- Precise measurements of lifetimes in the picosecond range of excited states in the stable even-A Sn isotopes 112,114,116,122Sn have been performed using the Doppler shift attenuation technique. For the first excited 2+ states in 112Sn, 114Sn and 116Sn the E2 transition strengths deduced from the measured lifetimes are in disagreement with the previously adopted values. They indicate a shallow minimum at N = 66 in contrast to the maximum at mid-shell predicted by modern shell model calculations.
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| 3. |
- Jungclaus, A., et al.
(författare)
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Evidence for reduced collectivity around the neutron mid-shell in the stable even-mass Sn isotopes from new lifetime measurements
- 2011
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 695:1-4, s. 110-114
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Tidskriftsartikel (refereegranskat)abstract
- Precise measurements of the lifetimes of the first excited 2(+) states in the stable even-A Sn isotopes Sn112-124 have been performed using the Doppler shift attenuation technique. For the isotopes Sn-112, Sn-114 and Sn-116 the E2 transition strengths deduced from the measured lifetimes are in disagreement with the previously reported values and indicate a shallow minimum at N = 66. The observed deviation from a maximum at mid-shell is attributed to the obstructive effect of the S-1/2 neutron orbital in generating collectivity when near the Fermi level. (C) 2010 Elsevier B.V. All rights reserved.
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| 4. |
- Walker, J., et al.
(författare)
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Magnetic moments of the first excited 2(+) states in the semi-magic Sn-112,Sn-114,Sn-116,Sn-122,Sn-124 isotopes
- 2011
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 84:1
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Tidskriftsartikel (refereegranskat)abstract
- The g factors of the first excited 2(+) states in the Sn-112,Sn-114,Sn-116,Sn-122,Sn-124 isotopes have been measured with high accuracy using the transient field technique in combination with Coulomb excitation in inverse kinematics. The experimental results are discussed in a qualitative way on the basis of empirical single-particle g factors of the relevant proton and neutron orbitals and are compared to a number of different theoretical calculations. The results are found to be best described by shell-model calculations in an extended configuration space. Clear evidence for the contribution of neutron pair excitations from the 1d(3/2) to the 0h(11/2) orbital to the wave function of the 2(1)(+) state in Sn-122,Sn-124 has been obtained.
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