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- Bureš, J., et al.
(författare)
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Significant decrease in prevalence of Helicobacter pylori in the Czech Republic
- 2012
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Ingår i: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327 .- 2219-2840. ; 18:32, s. 4412-4418
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Tidskriftsartikel (refereegranskat)abstract
- METHODS: A total of 22 centres entered the study. The catchment areas of these centres covered cities and towns with more than 20 000 inhabitants, smaller towns (<= 20 000 inhabitants) with surrounding villages and rural areas, and were spread over the whole country, corresponding well to the geographical distribution of the Czech population. A total of 1 837 subjects (aged 5-98 years) took part in the study, randomly selected out of 38 147 people from the general population. H. pylori infection was investigated by means of a C-13-urea breath test. Breath samples in duplicates were analysed using isotope ratio mass spectrometry. The cut-off point was 3.5. Social and demographic characteristics were based on data from self-completed questionnaires. RESULTS: The overall prevalence of H. pylori infection was 23.5% (430/1826), and 4.8% (20/420) in children aged 15 or less. There was no statistically significant difference in prevalence between males (24.3%; 208/857) and females (22.9%, 222/969, P = 0.494). H. pylon infection was strongly associated with higher age, among subjects aged 55+ years, prevalence of H. pylori infection was 39.8% (252/633, P < 0.001). The highest prevalence of H. pylori infection was found among persons aged 55-64 years (43.9%, 97/221) and 75+ years (37.9%, 58/153). Among study subjects aged 15+ years, prevalence of H. pylori infection was significantly increased in those with lowest education (odds risk 3.19, 95% CI 1.87-5.47). Compared to never married (14.1%), the prevalence of H. pylori infection was statistically significantly higher among married (35.4%, 246/694, P < 0.001), divorced (36.8%, 49/133, P < 0.001) and widowed study subjects (40.2%, 45/112, P < 0.001), both in minimally and fully adjusted analysis. There was no significant difference in the prevalence of H. pylori infection between married and widowed subjects (35.4%, 246/694 vs 40.2%, 45/112, P = 0.389). There was little variation in smoking prevalence across categories of smoking and there was no evidence of an increased risk of H. pylon infection among current or past smokers in our data (odds risk 1.04 with 95% CI 0.78-1.40 for current smokers; odds ratio 0.83 with 95% CI 0.60-1.16 for former smokers). The current prevalence of H. pylori in 2011 was significantly lower compared to the prevalence reported from identical geographical areas in 2001 (23.5% vs 41.7%, P < 0.001). CONCLUSION: The overall prevalence of H. pylon infection in the general population has fallen substantially in the Czech Republic over the past 10 years.
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- Rejchrt, S., et al.
(författare)
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Prevalence of dyspepsia in the Czech Republic - prospective multi-centre study
- 2012
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Konferensbidrag (refereegranskat)abstract
- INTRODUCTION/OBJECTIVES: Although a substantial proportion of the population experiences dyspepsia, only a minority of them seek medical care.AIMS & METHODS: The aim of this prospective multi-centre study was to determine the prevalence of investigated and uninvestigated dyspepsia in a representative sample of general non-selected population of the Czech Republic. A total of 1,837 subjects (aged 5-98 years) from 22 centres corresponding well to the geographical distribution entered the study. Two-step random selection was performed centrally out of 38,147 people from the registered general population. Helicobacter pylori (Hp) infection was investigated by means of 13C-UBT (INFAI, Köln, Germany). There were no preliminary exclusion criteria. Symptoms of dyspepsia, with severity measured on a scale from zero (no problems) to 10 (the worst problems), social and demographic characteristics were obtained from self-completed questionnaires from particular subjects and other health-related data were retrieved from records of general practitioners.RESULTS: Most of the people considered themselves to be healthy (87.2%; 1602/1,837). Dyspeptic symptoms (frequently recurrent or lasting longer than 6 months) were reported by only 12.3% (226/1,837) of subjects. Those suffering from dyspepsia mostly evaluated their symptoms as acceptable (mean severity score 4.3±1.8; median 5.0). Only 48.7% (110/226) of people suffering from recurrent or long-lasting dyspepsia sought medical care and were investigated by a specialist. Dyspepsia as the only long-lasting symptom and the subjects feeling otherwise healthy was found mostly among younger subjects and/or those with higher education. These subjects might fulfil criteria for functional dyspepsia in most cases. Subjects with dyspepsia as part of a complex of previously recognised diseases are mostly older people (with structural/organic or secondary dyspepsia). The prevalence of dyspepsia (of any type) seemed to be higher among women (54.9%; 124/226 vs. 45.1%; 102/226; NS). Results of the 13C-UBT for Hp status were obtained in 99.5% (1,828/1,837) of subjects. The overall prevalence of Hp infection was 23.6% (432/1828). There was no difference in dyspeptic symptoms between Hp-positive and Hp-negative subjects.CONCLUSION: The prevalence of dyspepsia in the Czech Republic is comparable with data from other European countries. We have found no association between Hp and the presence or absence of dyspepsia in our setting. There are clearly distinct subgroups of dyspeptic patients that should be further studied.
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