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| 2. |
- Porcu, E, et al.
(författare)
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Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 3300-
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most of these variants overlap with expression QTLs, indicating their potential involvement in regulation of gene expression. Here, we propose a transcriptome-wide summary statistics-based Mendelian Randomization approach (TWMR) that uses multiple SNPs as instruments and multiple gene expression traits as exposures, simultaneously. Applied to 43 human phenotypes, it uncovers 3,913 putatively causal gene–trait associations, 36% of which have no genome-wide significant SNP nearby in previous GWAS. Using independent association summary statistics, we find that the majority of these loci were missed by GWAS due to power issues. Noteworthy among these links is educational attainment-associated BSCL2, known to carry mutations leading to a Mendelian form of encephalopathy. We also find pleiotropic causal effects suggestive of mechanistic connections. TWMR better accounts for pleiotropy and has the potential to identify biological mechanisms underlying complex traits.
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| 4. |
- Carter, J. A., et al.
(författare)
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Ground-based and additional science support for SMILE
- 2024
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Ingår i: Earth and Planetary Physics. - : Science Press. - 2096-3955. ; 8:1, s. 275-298
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Tidskriftsartikel (refereegranskat)abstract
- The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions, and simultaneously monitor the auroral response of the Northern Hemisphere ionosphere. Combining these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE mission. Here, we describe current community efforts to prepare for SMILE, and the benefits and context various experiments that have explicitly expressed support for SMILE can offer. A dedicated group of international scientists representing many different experiment types and geographical locations, the Ground-based and Additional Science Working Group, is facilitating these efforts. Preparations include constructing an online SMILE Data Fusion Facility, the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar, and the consideration of particular observing strategies and spacecraft conjunctions. We anticipate growing interest and community engagement with the SMILE mission, and we welcome novel ideas and insights from the solar-terrestrial community.
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| 5. |
- Nakamura, R., et al.
(författare)
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Flow bouncing and electron injection observed by Cluster
- 2013
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Ingår i: Journal of Geophysical Research-Space Physics. - : American Geophysical Union (AGU). - 2169-9380. ; 118:5, s. 2055-2072
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Tidskriftsartikel (refereegranskat)abstract
- Characteristics of particles and fields in the flow-bouncing region are studied based on multipoint observations from Cluster located at 13-15R(E) downtail during a substorm event around 12:50 UT on 7 September 2007. The Cluster spacecraft were separated by a distance of up to 10,000 km and allowed to determine the mesoscale evolution of the current sheet as well as the development of the dipolarization front. We show that the flow bouncing took place associated with a tailward-directed j x B force in a disturbed current sheet in addition to an enhanced tailward pressure gradient force. Multiple Earthward propagating dipolarization fronts accompanied by enhanced flux of energetic electrons were observed before the flow bouncing. The sequence of events started with a localized dipolarization front and ended with a large scale (>10R(E)) dipolarization front accompanied by a major increase in energetic electrons at all spacecraft and immediately followed by flow bouncing. Multiple dipolarization fronts result in the formation of compressed magnetic field with a plasma bulge bounded by thin ion-scale current layers, a favorable condition for flow bouncing. These observations suggest that to understand the flow bouncing and related acceleration of plasma in the near-Earth tail, both the large-scale MHD properties and the transient and small-scale effect of the plasma interaction with the Earth-dipole field need to be taken into account.
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| 6. |
- Branduardi-Raymont, G., et al.
(författare)
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Exploring solar-terrestrial interactions via multiple imaging observers
- 2022
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Ingår i: Experimental astronomy. - : Springer Nature. - 0922-6435 .- 1572-9508. ; 54:2-3, s. 361-390
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Tidskriftsartikel (refereegranskat)abstract
- How does solar wind energy flow through the Earth's magnetosphere, how is it converted and distributed? is the question we want to address. We need to understand how geomagnetic storms and substorms start and grow, not just as a matter of scientific curiosity, but to address a clear and pressing practical problem: space weather, which can influence the performance and reliability of our technological systems, in space and on the ground, and can endanger human life and health. Much knowledge has already been acquired over the past decades, particularly by making use of multiple spacecraft measuring conditions in situ, but the infant stage of space weather forecasting demonstrates that we still have a vast amount of learning to do. A novel global approach is now being taken by a number of space imaging missions which are under development and the first tantalising results of their exploration will be available in the next decade. In this White Paper, submitted to ESA in response to the Voyage 2050 Call, we propose the next step in the quest for a complete understanding of how the Sun controls the Earth's plasma environment: a tomographic imaging approach comprising two spacecraft in highly inclined polar orbits, enabling global imaging of magnetopause and cusps in soft X-rays, of auroral regions in FUV, of plasmasphere and ring current in EUV and ENA (Energetic Neutral Atoms), alongside in situ measurements. Such a mission, encompassing the variety of physical processes determining the conditions of geospace, will be crucial on the way to achieving scientific closure on the question of solar-terrestrial interactions.
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| 7. |
- Grigorenko, E. E., et al.
(författare)
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Intense Current Structures Observed at Electron Kinetic Scales in the Near-Earth Magnetotail During Dipolarization and Substorm Current Wedge Formation
- 2018
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 45:2, s. 602-611
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Tidskriftsartikel (refereegranskat)abstract
- We use data from the 2013-2014 Cluster Inner Magnetosphere Campaign, with its uniquely small spacecraft separations (less than or equal to electron inertia length, lambda(e)), to study multiscale magnetic structures in 14 substorm-related prolonged dipolarizations in the near-Earth magnetotail. Three time scales of dipolarization are identified: (i) a prolonged growth of the B-Z component with duration <= 20 min; (ii) B-Z pulses with durations <= 1 min during the B-Z growth; and (iii) strong magnetic field gradients with durations <= 2 s during the dipolarization growth. The values of these gradients observed at electron scales are several dozen times larger than the corresponding values of magnetic gradients simultaneously detected at ion scales. These nonlinear features in magnetic field gradients denote the formation of intense and localized (approximately a few lambda(e)) current structures during the dipolarization and substorm current wedge formation. These observations highlight the importance of electron scale processes in the formation of a 3-D substorm current system.
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| 8. |
- Andersson, M., et al.
(författare)
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A New Class of Labile Surfactants that Break Down to Non-surface Active Products upon Heating or after a Pre-set Time, without the Need for a pH Change
- 2007
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Ingår i: Tenside Surfactants Detergents. - : Walter de Gruyter GmbH. - 0932-3414 .- 2195-8564. ; 44:6, s. 366-372
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Tidskriftsartikel (refereegranskat)abstract
- A new class of labile surfactants that break down at a controllable rate without the need for a change in pH will be presented. The invention has been patented by YKI Institute for Surface Chemistry, and is based on use of β-keto acids or their salts as surface-active compounds. These surfactants spontaneously break down through decarboxylation, to form an oil-like ketone and CO 2/HCO 3 -/CO 32 - depending on pH. The rate of breakdown can be controlled within a wide range by temperature or by certain additives, but, unlike most cleavable surfactants, a change in pH is not needed. Furthermore the surfactants can be conveniently activated from a stabile precursor just before use, and one (of many possible) precursors of this kind is already available on the industrial scale in the form of a wellknown chemical that is FDA-approved in other, non-surfactant, applications. The compound in question, alkyl ketene dimer (AKD), is produced in large scale by a number of large chemical producers today, and used for hydrophobization of paper. The present article gives an overview of the surfactant chemistry, with focus on recent studies of the kinetics of activation of the surfactant precursor and breakdown kinetics of the labile surfactant at different conditions. Furthermore, possible industrial applications of the surfactant will be discussed, with one example taken from a recent feasibility study performed within the car washing area. © Carl Hanser Publisher.
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| 9. |
- Kronberg, E. A., et al.
(författare)
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Comparing and contrasting dispersionless injections at geosynchronous orbit during a substorm event
- 2017
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Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 122:3, s. 3055-3072
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Tidskriftsartikel (refereegranskat)abstract
- Particle injections in the magnetosphere transport electrons and ions from the magnetotail to the radiation belts. Here we consider generation mechanisms of dispersionless injections, namely, those with simultaneous increase of the particle flux over a wide energy range. In this study we take advantage of multisatellite observations which simultaneously monitor Earth's magnetospheric dynamics from the tail toward the radiation belts during a substorm event. Dispersionless injections are associated with instabilities in the plasma sheet during the growth phase of the substorm, with a dipolarization front at the onset and with magnetic flux pileup during the expansion phase. They show different spatial spread and propagation characteristics. Injection associated with the dipolarization front is the most penetrating. At geosynchronous orbit (6.6R(E)), the electron distributions do not have a classic power law fit but instead a bump on tail centered on similar to 120keV during dispersionless electron injections. However, electron distributions of injections associated with magnetic flux pileup in the magnetotail (13R(E)) do not show such a signature. We surmise that an additional resonant acceleration occurs in between these locations. We relate the acceleration mechanism to the electron drift resonance with ultralow frequency waves localized in the inner magnetosphere.
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| 10. |
- Fu, H. S., et al.
(författare)
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Pitch angle distribution of suprathermal electrons behind dipolarization fronts : A statistical overview
- 2012
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Ingår i: Journal of Geophysical Research. - : American Geophysical Union (AGU). - 0148-0227 .- 2156-2202. ; 117:12
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Tidskriftsartikel (refereegranskat)abstract
- We examine the pitch angle distribution (PAD) of suprathermal electrons (> 40 keV) inside the flux pileup regions (FPRs) that are located behind the dipolarization fronts (DFs), in order to better understand the particle energization mechanisms operating therein. The 303 earthward-propagating DFs observed during 9 years (2001-2009) by Cluster 1 have been analyzed and divided into two groups according to the differential fluxes of the > 40 keV electrons inside the FPR. One group, characterized by the low flux (F < 500/cm(2) , s . sr . keV), consists of 153 events and corresponds to a broad distribution of IMF Bz components. The other group, characterized by the high flux (F >= 500/cm(2) . s . sr . keV), consists of 150 events and corresponds to southward IMF Bz components. Only the high-flux group is considered to investigate the PAD of the > 40 keV electrons as the low-flux situation may lead to large uncertainties in computing the anisotropy factor that is defined as A = F-perpendicular to/F-parallel to - 1 for F-perpendicular to > F-parallel to, and A = -F-parallel to/F-perpendicular to + 1 for F-perpendicular to < F-parallel to. We find that, among the 150 events, 46 events have isotropic distribution (vertical bar A vertical bar <= 0.5); 60 events have perpendicular distribution (A > 0.5), and 44 events have field-aligned distribution inside the FPR (A < -0.5). The perpendicular distribution appears mainly inside the growing FPR, where the flow velocity is increasing and the local flux tube is compressed. The field-aligned distribution occurs mainly inside the decaying FPR, where the flow velocity is decreasing and the local flux tube is expanding. Inside the steady FPR, we observed primarily the isotropic distribution of suprathermal electrons. This statistical result confirms the previous case study and gives an overview of the PAD of suprathermal electrons behind DFs.
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