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- Wuttke, Matthias, et al.
(författare)
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A catalog of genetic loci associated with kidney function from analyses of a million individuals
- 2019
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Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
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Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
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| 4. |
- Ankre, Rosemarie, 1975-, et al.
(författare)
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Opportunities and Challenges for Accessibility to Outdoor Recreation in an Urban Environment : A Case Study of Östersund, Sweden
- 2017
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Konferensbidrag (refereegranskat)abstract
- Practically all Swedes enjoy being out in nature and engaging in outdoor recreation activities. An important reason behind this is that they benefit from the Swedish Public Right of Access (Allemansrätten). Outdoor recreation is highlighted as a major contributor to good health, leads to a higher level of understanding of nature in an urban society, and can function as a means of integration and sustainable development. However, society and our constant search for new experiences are changing as does the practice of outdoor recreation.It is of interest to identify how different users participate in outdoor recreation and use nature. Previous studies show that outdoor recreation often is conducted close to where we live. Planning and management, along with information, are vital components leading to the accessibility and development of outdoor recreation. Accessibility for outdoor recreation relate to both physical and socio-economic conditions. Today, outdoor recreation for urban dwellers is highly dependent on access to natural areas close to cities, yet open spaces are increasingly under threat due to urban growth and development density. The Public Right of Access places new demands on future planning and management, for example in order to prevent conflicts with private landowners as there may be increased pressure on specific natural areas.The above issues are analyzed from the results of an online survey conducted in autumn 2016. The survey was sent to 3,000 randomly selected residents in Östersund, Sweden (response rate 32%). Additionally, municipal planning documents are examined. The results show that the respondents do not consider that access to nature is constrained. Rather they feel they lack the time to make full use of this accessibility. They also express a need for more information about nature areas. The results also show that those with higher education and higher income value outdoor recreation higher, but that they also have less time.
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| 7. |
- Gorski, Mathias, et al.
(författare)
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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
- 2022
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Ingår i: Kidney International. - : Elsevier. - 0085-2538 .- 1523-1755. ; 102:3, s. 624-639
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Tidskriftsartikel (refereegranskat)abstract
- Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genomewide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR- baseline (11 novel, one known for this phenotype), including nine variants robustly associated across models were identified. All loci for eGFR-decline were known for cross-sectional eGFR and thus distinguished a subgroup of eGFR loci. Seven of the nine variants showed variant- by-age interaction on eGFR cross section (further about 350,000 individuals), which linked genetic associations for eGFR-decline with agedependency of genetic cross- section associations. Clinically important were two to four-fold greater genetic effects on eGFR-decline in high-risk subgroups. Five variants associated also with chronic kidney disease progression mapped to genes with functional in- silico evidence (UMOD, SPATA7, GALNTL5, TPPP). An unfavorable versus favorable nine-variant genetic profile showed increased risk odds ratios of 1.35 for kidney failure (95% confidence intervals 1.03- 1.77) and 1.27 for acute kidney injury (95% confidence intervals 1.08-1.50) in over 2000 cases each, with matched controls). Thus, we provide a large data resource, genetic loci, and prioritized genes for kidney function decline, which help inform drug development pipelines revealing important insights into the age-dependency of kidney function genetics.
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| 8. |
- Gorski, Mathias, et al.
(författare)
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Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
- 2021
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Ingår i: Kidney International. - : Elsevier. - 0085-2538 .- 1523-1755. ; 99:4, s. 926-939
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Tidskriftsartikel (refereegranskat)abstract
- Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
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| 9. |
- Höpken, Wolfram, et al.
(författare)
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Big data as input for predicting tourist arrivals
- 2017
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Ingår i: Information and Communication Technologies in Tourism 2017. - Cham : Springer. - 9783319511672 - 9783319511689 ; , s. 187-199
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Konferensbidrag (refereegranskat)abstract
- International tourist arrivals increased by over 4,000% during the last 60 years, and as a labour-intensive business, tourism destinations and suppliers strongly depend on precise predictions of tourism demand. This study compares an autoregressive approach to predict tourism demand which is using past arrivals as input with an approach which predicts arrivals based on big data information as additional input, like the destination price level or the web search traffic per sending country, respectively. As prediction methods, the study uses the statistical approach of the linear regression and the data mining technique k-nearest neighbour (k-NN). Both approaches are executed and evaluated for the leading Swedish mountain destination Åre on the base of arrival data and big data sources for the time period 2005–2012. Study results show that (1) big data information sources can significantly increase the prediction performance of tourist arrivals compared to using past arrivals alone (i.e. autoregressive approach) and (2) data mining techniques (i.e. k-NN) can outperform statistical approaches, like linear regression.
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