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1.	Labberton, L, et al. (author) Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection 2016 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 12616- Journal article (peer-reviewed)abstract Polyphosphate is an inorganic procoagulant polymer. Here we develop specific inhibitors of polyphosphate and show that this strategy confers thromboprotection in a factor XII-dependent manner. Recombinant Escherichia coli exopolyphosphatase (PPX) specifically degrades polyphosphate, while a PPX variant lacking domains 1 and 2 (PPX_Δ12) binds to the polymer without degrading it. Both PPX and PPX_Δ12 interfere with polyphosphate- but not tissue factor- or nucleic acid-driven thrombin formation. Targeting polyphosphate abolishes procoagulant platelet activity in a factor XII-dependent manner, reduces fibrin accumulation and impedes thrombus formation in blood under flow. PPX and PPX_Δ12 infusions in wild-type mice interfere with arterial thrombosis and protect animals from activated platelet-induced venous thromboembolism without increasing bleeding from injury sites. In contrast, targeting polyphosphate does not provide additional protection from thrombosis in factor XII-deficient animals. Our data provide a proof-of-concept approach for combating thrombotic diseases without increased bleeding risk, indicating that polyphosphate drives thrombosis via factor XII.
2.	Sala-Cunill, A, et al. (author) Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions 2015 In: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 135:4, s. 1031- Journal article (peer-reviewed)
3.	Bulajeva, A, et al. (author) Medication review practices in European countries 2014 In: Research in social & administrative pharmacy : RSAP. - : Elsevier BV. - 1934-8150 .- 1551-7411. ; 10:5, s. 731-740 Journal article (peer-reviewed)
4.	Bulajeva, A, et al. (author) Medication review practices in European countries 2015 In: INTERNATIONAL JOURNAL OF CLINICAL PHARMACY. - 2210-7703. ; 37, s. 25-25 Conference paper (other academic/artistic)
5.	Labberton, L, et al. (author) A Flow Cytometry-Based Assay for Procoagulant Platelet Polyphosphate 2018 In: Cytometry. Part B, Clinical cytometry. - : Wiley. - 1552-4957 .- 1552-4949. ; 94:2, s. 369-373 Journal article (peer-reviewed)
6.	Labberton, L, et al. (author) Challenges in oral administration of metronidazole dissolved in drinking water to rhesus monkeys (Macaca mulatta) 2013 In: Lab animal. - : Springer Science and Business Media LLC. - 1548-4475 .- 0093-7355. ; 42:6, s. 213-216 Journal article (peer-reviewed)
7.	Labberton, L, et al. (author) EXOPOLYPHOSPHATASE BASED STRATEGIES FOR INTERFERENCE WITH PROCOAGULANT POLYPHOSPHATE ACTIVITIES 2016 In: THROMBOSIS RESEARCH. - 0049-3848. ; 141, s. S1-S1 Conference paper (other academic/artistic)
8.	Labberton, L, et al. (author) New agents for thromboprotection. A role for factor XII and XIIa inhibition 2015 In: Hamostaseologie. - 2567-5761. ; 35:4, s. 338- Journal article (peer-reviewed)
9.	Larsson, M, et al. (author) Inhibition of coagulation factor XII provides thromboprotection in extracorporeal circulation without increasing bleeding risk 2013 In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. - 1538-7933. ; 11, s. 31-31 Conference paper (other academic/artistic)
10.	Larsson, M, et al. (author) Polyphosphatehosphate is an haemostatic agent in vivo 2013 In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. - 1538-7933. ; 11, s. 1111-1111 Conference paper (other academic/artistic)

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Type of publication: journal article (7); conference paper (4)

Type of content: peer-reviewed (7); other academic/artistic (4)

Author/Editor: Labberton, L (11); Renne, T (8); Nickel, KF (5); Kenne, E (3); Long, AT (3); Maas, C (3); show more...; Stavrou, EX (3); Larsson, M (2); Di Gennaro, A (2); Butler, L. (2); Bulajeva, A (2); Leikola, S (2); Pohjanoksa-Mantyla, ... (2); Airaksinen, M (2); Hernandez, JS (2); Fuchs, T. (1); Kumar, P. (1); Long, A. (1); de Gier, H (1); Bakker, J (1); Luengo, O (1); Cardona, V (1); Butler, LM (1); Langermans, JAM (1); Bjorkqvist, J (1); Sala-Cunill, A (1); Nolte, MW (1); Stavrou, E (1); Jamsa, A (1); Blankenberg, S (1); Geurts, MME (1); de Gier, JJ (1); Dickneite, G (1); Langer, F (1); Schlüter, H (1); Fuchs, TA (1); Krieger, T (1); McCrae, K (1); Gendler, SJ (1); Snozek, CL (1); Klomp, R (1); van Geijlswijk, IM (1); Rigg, RA (1); Rayzman, V (1); Pragst, I (1); Theinert, K (1); Panousis, K (1); Corbascio, CO (1); Guilarte, M (1); Labrador, M (1); show less...

University: Karolinska Institutet (11)

Language: English (11)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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