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Sökning: WFRF:(Laino R)

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  • Hultborn, Ragnar, 1946, et al. (författare)
  • Efficacy of pamidronate in breast cancer with bone metastases: a randomized, double-blind placebo-controlled multicenter study
  • 1999
  • Ingår i: Anticancer Res. - 0250-7005. ; 19:4C, s. 3383-92
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: To evaluate the efficacy of pamidronate 60 mg i.v. q 4 weeks in women with advanced breast cancer with skeletal metastases. PATIENTS AND METHODS: 404 woman with skeletal metastases from breast cancer in Sweden and Norway were included in a randomized, placebo-controlled, multicenter study. Except for the study medication, other palliative treatment was chosen at the discretion of the physician. Skeletal related events, i.e. increased pain, treatment of hypercalcemia, pathologic fractures of long bones or pelvis, paralyses due to vertebral compression, palliative radiotherapy for skeletal metastases, surgery on bone and change of antitumor therapy were recorded every third month as well as a self-estimated pain-score using visual Analog Scales and analgesic consumption. RESULTS: There was a significantly increased time to progression of pain (p < 0.01), to hypercalcemic events (p < 0.05) as well as for the cumulative number of skeletal related events (p < 0.01) in favor for the pamidronate group. No statistically significant reduction of pathologic fractures of long bones or pelvis, or pareses due to vertebral compression occurred. No statistically significant differences were found for the need of radiotherapy and surgery on bone. The pamidronate group faired better regarding performance status (p < 0.05). There was a statistically not significant lower consumption of opioid analgesics in the pamidronate group (p = 0.14). CONCLUSION: Pamidronate 60 mg i.v. q 4 weeks reduces skeletal events and improves the quality of life in women with bone metastases from breast cancer.
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  • De Bona, J., et al. (författare)
  • Differences in the Sliding Wear Track Patterns Between UHMWPE/Steel and UHMWPE/CNx Pairs
  • 2012
  • Ingår i: Procedia Materials Science. - : Elsevier. - 2211-8128. ; 1, s. 329-336
  • Tidskriftsartikel (refereegranskat)abstract
    • This work explores the effect of surface modification of stainless steel with a carbon nitride (CNx) film, under sliding wear of the UHMWPE/steel. Wettatibility of CNx coatings is assessed by means of the sessile drop method using two different liquid media. Microhardness and stiffness of CNx coatings are estimated by depth-sensing indentation. The sliding performance of UHMWPE against stainless steel and CNx was evaluated using a pin on disk tribometer. It is demonstrated that CNx surface properties are quite different from those of stainless steel, with a concomitant substantial reduction of the coefficient of friction of UHMWPE/CNx in comparison with the one of UHMWPE/steel under sliding conditions. Even tough imposed sliding conditions do not conduct to wear mass loss in UHMWPE, wear track patterns against steel and CNx are quite different.
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  • Resultat 1-4 av 4

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