| 1. |
- Lindström, Jonas, 1977-, et al.
(författare)
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Uppgifter om mäns och kvinnors försörjningsaktiviteter i häradsrättens protokoll, Snevringe (Västmanland), perioden 1720-1880
- 2020
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Annan publikationabstract
- Uppgifter om mäns och kvinnors försörjningsaktiviteter i Snevringe (Västmanland) häradsrätts protokoll har transkriberats och analyserats, och källtext och källtrogna variabler registrerats bokstavstroget, av Jonas Lindström, Benny Jacobsson, Carl Mikael Carlsson, Karin Hassan Jansson, Linnea Henningsson, Maria Ågren, Sarah Vorminder och Örjan Kardell, inom forskningsprojektet Gender and Work.Kvalitetskontroll är utförd av Sofia Ling och Jonas Lindström.Analys av källmaterialet har gjorts av Benny Jacobsson, Carl Mikael Carlsson, Karin Hassan Jansson, Linnea Henningsson, Maria Ågren, Sarah Vorminder, Örjan Kardell inom projektet Gender and Work https://www.uu.se/gawMaterialet är sökbart i databasen GAW - https://gotham.ddb.umu.se/
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| 2. |
- Berg, Elisabeth Gräslund, et al.
(författare)
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Praktiker som gör skillnad : Om den verb-inriktade metoden
- 2013
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Ingår i: Historisk Tidskrift. - 0345-469X .- 2002-4827. ; 133:3, s. 335-354
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Tidskriftsartikel (refereegranskat)abstract
- This article discusses the so-called verb-oriented method and its role in the research project Gender and Work in early modern Sweden (GaW), which is based at Uppsala University. It provides a presentation of the GaW-database, which has been designed to allow analysis according to the verb-method. Finally, the article points out that this method can be combined with a number of different theoretical approaches as long as the focus is on practices. It is therefore compatible with the approaches of e.g., Judith Butler, Michel de Certeau, and Amartya Sen. Work is defined as "time-use with the purpose of making a living" and the article discusses why data on time-use, or actual work activities, are better suited for research into early modern Swedish working life than other types of data. It shows that activities are usually described in the sources by verb-phrases, and explains how and from what sources verb-phrases are collected and analyzed within the project. In order to allow for generalizations the verb-method presupposes large amounts of data. This is the rationale for the GaW-database, which at present includes around 5000 verb-phrases and 75000 data posts.
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| 3. |
- Cedres, Nira, et al.
(författare)
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Subjective Impairments in Olfaction and Cognition Predict Dissociated Behavioral Outcomes
- 2022
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Ingår i: The journals of gerontology. Series B, Psychological sciences and social sciences. - : Oxford University Press (OUP). - 1079-5014 .- 1758-5368. ; 78:1, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Self-rated subjective cognitive decline (SCD) and subjective olfactory impairment (SOI) are associated with objective cognitive decline and dementia. However, their relationship and co-occurrence is unknown. We aimed to (a) describe the occurrence of SOI, SCD and their overlap in the general population; (b) compare SOI and SCD in terms of longitudinal associations with corresponding objective olfactory and cognitive measures; and (c) describe how SOI and SCD may lead to distinct sensory and cognitive outcomes.Methods: Cognitively unimpaired individuals from the third wave of the Swedish population-based Betula study (n = 784, aged 35–90 years; 51% females) were split into self-rated SOI, SCD, overlapping SCD + SOI, and controls. Between-subject and within-subject repeated-measures MANCOVA were used to compare the groups regarding odor identification, cognition, age, sex, and education. Spearman correlation was used to assess the different patterns of association between olfaction and cognition across groups.Results: SOI was present in 21.1%, whereas SCD was present in 9.9% of participants. According to a chi-square analysis, the SCD + SOI overlap (2.7%) is on a level that could be expected if the phenomena were independent. Odor identification in SOI showed decline at the 10-year follow-up (n = 284) and was positively associated with cognition. The SOI and SCD groups showed distinct cognitive-olfactory profiles at follow-up.Conclusions: SOI occur independently of SCD in the population, and these risk factors are associated with different cognitive and olfactory outcomes. The biological causes underlying SOI and SCD, as well as the risk for future cognitive impairment, need further investigation.
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| 4. |
- Fiebranz, Rosemarie, 1959-, et al.
(författare)
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Working Together
- 2016
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Ingår i: <em>Making a Living, Making a Difference</em>. - New York : Oxford University Press. - 9780190240615
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Bokkapitel (refereegranskat)
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| 5. |
- Hodge, David, et al.
(författare)
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Impact of hemicellulose pre-extraction for bioconversion on birch kraft pulp properties
- 2009
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The carbohydrate portion of lignocellulosic feedstocks are ideally suited to conversion via biochemical transformations because of their crucial role in cellular metabolism. The combination of hemicelluloses extraction with pulping processes could be one way to generate a sugar feedstock amenable to biochemical transformation to fuels and chemical intermediates. White liquor, green liquor, and water HC extractions of birch wood were performed under conditions compatible with the Kraft process, at different times, temperatures and alkali charges. The effective alkali charge was in extractions between 0%-7% and temperature between 130°C-160°C for 20-90 minutes. The xylan yields from different HC extractions were measured and the chips from select HC extractions were cooked, and the refined pulps were made into hand sheets. Several metrics for hand sheet quality were compared with a reference pulp made from the same wood chips. It is possible using white liquor to extract xylan from birch wood chips prior Kraft cooking without decreasing the pulp yield and paper strength properties, and at the same time achieve an impregnation of the wood chips. It is not possible in that extraction to attain extracted and hydrolyzed liquor containing a fermentable concentration of xylose, 2.63 g/L in this study. Increased extracted wood material, increased final acetic acid concentration and decreased final xylan concentration together with increased effective alkali charge at the same extraction temperature and time in white liquor extractions performed support that xylan degradation increases. Using white liquor or green liquor under the conditions investigated degrades xylan resulting in significant losses of xylose that could have been used as substrate in fermentation processes.
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| 6. |
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| 7. |
- Jacobsson, Amanda, et al.
(författare)
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”Ambulanssjukvården behöver genomgripande förändringar”
- 2021
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Ingår i: Dagens Medicin. - : Dagens Medicin. - 1402-1943. ; :2021-06-23
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Debattörer från Ambulance health research network vill se en nationell ledningsstruktur, ökad evidens för vården, akademisk kompetens i ledningsfunktioner samt en nationell utbildnings- och kompetensstandard.
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| 8. |
- Kalla, Rahul, et al.
(författare)
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EPIGENETIC ALTERATIONS IN IBD : DEFINING GEOGRAPHICAL, GENETIC, AND IMMUNEIN-FLAMMATORY INFLUENCES ON THE CIRCULATING METHYLOME
- 2021
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Ingår i: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 70:Suppl. 4, s. A5-A5
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: DNA methylation may provide critical insights into gene-environment interactions in inflammatory bowel disease (IBD).Methods: Using the multi-centre IBD Character inception cohort (295 controls, 154 CD, 161 UC, 28 IBD-U), epigenome-wide methylation was profiled using Illumina HumanMethylation450 platform. Differentially methylated position analysis was performed using age, sex and cell proportions as covariates. Integration of paired genomic and transcriptomic layers was done with Multi-Omics Factor Analysis v2 (MOFA). Unsupervised principal component analyses were performed to examine correlates of treatment escalation and clinical predictors of disease severity.Results: We report 137 differentially methylated positions (DMP) in whole blood in IBD, including VMP1/MIR21 (p=9.11×10-15) and RPS6KA2 (6.43×10-13); with consistency seen across Scandinavia and UK. Cell of origin analysis preferentially implicated the monocyte lineage. Dysregulated loci demonstrate strong genetic influence, notably VMP1 (p=1.53×10-15). Age acceleration is seen in IBD (coefficient 0.94, p<2.2x10-16). Several immuno-active genes demonstrated highly significant correlations between methylation and gene expression in IBD, in particular OSM: IBD r -0.32, p 3.64×10-7 vs. non-IBD r -0.14, p=0.77). Multi-omic integration of methylome, genome and transcriptome also identified specific pathways that associate with immune activation, response and regulation at disease inception. At follow up, a signature of 3 DMPs (TAP1, TESPA1, RPTOR) associated with treatment escalation to biological agents or surgery (hazard ratio of 5.19 (CI:2.14-12.56, logrank p=9.70×10-4).Conclusion: This study highlights the stability of the IBD-specific circulating methylome across regions with shared ancestry. Through integrative multi-omic analyses we identify key pro-inflammatory genes that are upregulated in IBD at inception. Furthermore, differential methylation within certain genes such as TAP1 associate with disease course over time.
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| 9. |
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| 10. |
- Nowak, Jan Krzysztof, et al.
(författare)
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Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease
- 2020
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Ingår i: Gastroenterology. - : American Gastroenterology Association Institute. - 0016-5085 .- 1528-0012. ; 159:3, s. 1151-1154
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Although the respiratory tract is implicated as the primary portal of entry of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), gastrointestinal involvement is well-reported, associated with nausea, vomiting, diarrhea, and highly persistent viral particle shedding in feces.(1,2)There is critical need to establish factors determining susceptibility to Coronavirus Disease 2019 (COVID-19) in patients with inflammatory bowel disease (IBD). Age, comorbidity, disease activity, and exposure to immunomodulatory and biological therapies provide the basis for new guidelines for risk stratification and shielding.(3)We hypothesize that expression levels of the SARS-CoV-2 spike protein receptor, angiotensin-converting enzyme 2 (ACE2),(4) may also determine susceptibility to SARS-CoV-2-inflicted damage. Transmembrane serine protease 2 (TMPRSS2) primes the viral spike protein,(5) allowing for the potent binding of ACE2. Both are known to be highly expressed in healthy ileal epithelium, with lower levels in epithelial cells in the colon. We report dysregulated mucosal ACE2 and TMPRSS2 expression in the colon and ileum in IBD, and identify the critical determinants of altered expression.
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