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Sökning: WFRF:(Loevenich S.)

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1.
  • Michel, M., et al. (författare)
  • Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
  • 2022
  • Ingår i: Science. - Stockholm : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 376:6600, s. 1471-1476
  • Tidskriftsartikel (refereegranskat)abstract
    • Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10-fold, and generates a previously undescribed b,d-lyase enzymatic function. TH10785 controls the catalytic activity mediated by a nitrogen base within its molecular structure. In cells, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. This alters the repair process, which no longer requires APE1 but instead is dependent on polynucleotide kinase phosphatase (PNKP1) activity. The increased repair of oxidative DNA lesions with a small molecule may have therapeutic applications in various diseases and aging. © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
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2.
  • Jokhovets, L., et al. (författare)
  • ADC-Based Real-Time Signal Processing for the PANDA Straw Tube Tracker
  • 2014
  • Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 61:6, s. 3627-3634
  • Tidskriftsartikel (refereegranskat)abstract
    • The PANDA (AntiProton Annihilations at Darmstadt) experiment is being built at the new Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany. PANDA will measure antiproton-proton annihilation reactions in the charm quark mass range to investigate the nature of the strong interaction. This particle physics experiment will run at very high reaction rates of 10-20 MHz. Our work is related to an ADC (analog-to-digital converter) based data acquisition system for the PANDA Straw Tube Tracker (STT). The STT will be able to deliver data rates up to 20 GByte/s through over 4600 signal channels and could require major efforts for the hardware implementation as well as high offline processing power. Test beam studies were carried out in order to specify a proper system architecture with feasible hardware and to reduce output data stream to a level suitable for offline processing. We analyze the strawtube response to both the proton beam and irradiation. Furthermore, we present real-time processing using the neighboring straw information and introduce the technique to reconstruct the tracks.
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