| 1. |
- Deans, Andrew R, et al.
(författare)
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Finding Our Way through Phenotypes.
- 2015
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Ingår i: PLoS Biology. - : Public Library of Science (PLoS). - 1545-7885. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility.
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| 2. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 3. |
- Tengvall, Katarina, 1980-, et al.
(författare)
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Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk
- 2019
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 116:34, s. 16955-16960
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Tidskriftsartikel (refereegranskat)abstract
- Multiple sclerosis (MS) is a chronic inflammatory, likely autoimmune disease of the central nervous system with a combination of genetic and environmental risk factors, among which Epstein-Barr virus (EBV) infection is a strong suspect. We have previously identified increased autoantibody levels toward the chloride-channel protein Anoctamin 2 (ANO2) in MS. Here, IgG antibody reactivity toward ANO2 and EBV nuclear antigen 1 (EBNA1) was measured using bead-based multiplex serology in plasma samples from 8,746 MS cases and 7,228 controls. We detected increased anti-ANO2 antibody levels in MS (P = 3.5 x 10(-36)) with 14.6% of cases and 7.8% of controls being ANO2 seropositive (odds ratio [OR] = 1.6; 95% confidence intervals [95% CI]: 1.5 to 1.8). The MS risk increase in ANO2-seropositive individuals was dramatic when also exposed to 3 known risk factors for MS: HLA-DRB1*15: 01 carriage, absence of HLA-A*02: 01, and high anti-EBNA1 antibody levels (OR = 24.9; 95% CI: 17.9 to 34.8). Reciprocal blocking experiments with ANO2 and EBNA1 peptides demonstrated antibody cross-reactivity, mapping to ANO2 [aa 140 to 149] and EBNA1 [aa 431 to 440]. HLA gene region was associated with anti-ANO2 antibody levels and HLADRB1*04: 01 haplotype was negatively associated with ANO2 seropositivity (OR = 0.6; 95% CI: 0.5 to 0.7). Anti-ANO2 antibody levels were not increased in patients from 3 other inflammatory disease cohorts. The HLA influence and the fact that specific IgG production usually needs T cell help provides indirect evidence for a T cell ANO2 autoreactivity in MS. We propose a hypothesis where immune reactivity toward EBNA1 through molecular mimicry with ANO2 contributes to the etiopathogenesis of MS.
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| 4. |
- Attié, David, et al.
(författare)
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A time projection chamber with GEM-based readout
- 2017
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 856, s. 109-118
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Tidskriftsartikel (refereegranskat)abstract
- For the International Large Detector concept at the planned International Linear Collider, the use of time projection chambers (TPC) with micro-pattern gas detector readout as the main tracking detector is investigated. In this paper, results from a prototype TPC, placed in a 1. T solenoidal field and read out with three independent Gas Electron Multiplier (GEM) based readout modules, are reported. The TPC was exposed to a 6. GeV electron beam at the DESY II synchrotron. The efficiency for reconstructing hits, the measurement of the drift velocity, the space point resolution and the control of field inhomogeneities are presented.
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| 5. |
- Carpenter, Stephen R., et al.
(författare)
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Accelerate Synthesis in Ecology and Environmental Sciences
- 2009
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Ingår i: BioScience. - : Oxford University Press (OUP). - 0006-3568 .- 1525-3244. ; 59:8, s. 699-701
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Tidskriftsartikel (refereegranskat)abstract
- Ecology is a leading discipline in the synthesis of diverse knowledge. Ecologists have had considerable experience in bringing together diverse, multinational data sets, disciplines, and cultural perspectives to address a wide range of issues in basic and applied science. Now is the time to build on this foundation and invest in ecological synthesis through new national or international programs. While synthesis takes place through many mechanisms, including individual efforts, working groups, and research networks, centers are extraordinarily effective institutional settings for advancing synthesis projects.
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| 6. |
- Dömstedt, Peter, et al.
(författare)
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Corrosion studies of a low alloyed Fe-10Cr-4Al steel exposed in liquid Pb at very high temperatures
- 2020
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Ingår i: Journal of Nuclear Materials. - : ELSEVIER. - 0022-3115 .- 1873-4820. ; 531
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the work has been to study the corrosion resistance of a new low alloyed experimental FeCrAl steel, with the potential use as corrosion barrier in high temperature lead based energy applications. The exposures were conducted in liquid lead at 800 degrees C and 900 degrees C, with controlled oxygen environment, for up to 1760 h. The results demonstrate that the new experimental alloy had formed a protective oxide in both exposures, with no indications of lead penetration. The alloy showed better corrosion properties than that of the reference materials: Kanthal APMT, Kanthal APMTT and AISI 316L. This indicates that the ductile Fe-10Cr-4Al-RE steel can be used as a corrosion barrier in liquid lead based clean energy applications, operating at very high temperatures.
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| 7. |
- Dömstedt, Peter, et al.
(författare)
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Corrosion Studies of Low-Alloyed FeCrAl Steels in Liquid Lead at 750 degrees C
- 2019
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Ingår i: Oxidation of Metals. - : SPRINGER/PLENUM PUBLISHERS. - 0030-770X .- 1573-4889. ; 91:3-4, s. 511-524
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Tidskriftsartikel (refereegranskat)abstract
- New ductile experimental FeCrAl alloys, based on the composition of Fe-10Cr-4Al, were exposed to stagnant liquid lead at 750 degrees C for up to 1970h. Two exposures with different test conditions were performed: one with addition of oxygen (as H2O) to the liquid lead and one without. The experimental alloys showed generally good oxidation and self-healing properties. The exposures showed that this specific category of steels has the potential to operate in liquid lead at very high temperatures with only minor oxidation. With this new material development, new energy technologies such as the CSP plants may be able to utilize liquid lead at very high temperatures as heat transfer fluid, thus achieving increased thermal efficiency.
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| 8. |
- Dömstedt, Peter
(författare)
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Development of Alumina Forming Alloys for High-Temperature Energy Applications
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Liquid lead as heat transfer fluid presents attractive features for future power technologies, such as next-generation nuclear reactors, thermal solar power, and thermal storage. Liquid lead has excellent heat transfer properties well suited for operating at high temperatures. While today's water-cooled reactors operate at a temperature of approximately 300°C, the next-generation lead-cooled nuclear power could operate up to 600°C, significantly increasing the energy conversion efficiency. However, it is well known that liquid lead is a corrosive medium for stainless steels, especially at temperatures above 500°C.To address the corrosion issues, aluminium oxide-forming ferritic steels have been thoroughly studied in liquid lead environments and have shown good oxidation properties. Traditionally, these steels are alloyed with 3-6 wt% aluminium and 12-24 wt% chromium, and iron as balance, hence the denotation FeCrAl steel. However, the high addition of aluminium and chromium results in poor weldability and renders them susceptible to embrittlement in the desired temperature range. Therefore, to address the welding and embrittlement issues, a new group of FeCrAl materials was developed in recent years with only 10 wt% chromium and 4 wt% aluminium, which in this work is referred to as Fe-10Cr-4Al. These alloys have shown good ductility and good corrosion properties in liquid lead up to 550°C.In this work, the Fe-10Cr-4Al steels have been further optimised and exposed to liquid lead at temperatures up to 900°C. In addition, detailed studies of the oxidation properties and structure formed on the steel surfaces were conducted using various analytical techniques. The findings showed that the most promising Fe-10Cr-4Al steel, so far, has suitable corrosion properties up to 800°C. However, although these steels have improved mechanical and welding properties, they do not meet the requirements set for the desired high-temperature energy applications.Therefore, another new family of alloys was developed, namely alumina-forming martensitic steels. This development aimed to combine the superior corrosion resistance of the aluminium oxide with the mechanical properties inherent in the martensitic structure. The development was done using thermodynamic modelling, empirical corrosion studies and detailed analytical methods. The results showed that these martensitic steels have a corrosion resistance exceeding even the best1optimised Fe-10Cr4-Al steel in liquid lead at temperatures up to at least 550°C.In parallel, alumina-forming austenitic steels were also developed. The aim was to find a suitable composition for these materials that not only provide good corrosion protection in liquid lead, but also good weldability, good phase stability, and good formability. These austenitic materials have shown, in general, good corrosion properties in liquid lead up to 600°C. However, the combination of elevated Ni, Al and Mn levels resulted in embrittlement after ageing at 600°C. In addition, a series of austenitic alumina-forming welding materials were also developed within this work. The aim was to produce a material that does not suffer from the embrittlement commonly observed in ferritic welds. Bend testing of this welding material has, so far, indicated ductile behaviour with good formability.
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| 9. |
- Dömstedt, Peter, et al.
(författare)
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New Alumina Forming Martensitic Steels
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The work presents a new category of alloys, Alumina Forming Martensitic (AFM) steels, developed for new clean energy power applications such as thermal solar power and Gen IV nuclear power. The aim was to combine the superior corrosion resistance of the alumina scale with the excellent creep properties of the martensitic structure. The alloys were exposed to liquid lead at 550°C for 1824 hours to evaluate their oxidation properties. In addition, the microstructures were analysed in annealed conditions and after the exposure to assess phase stabilities. Using a variety of characterisation techniques, the studies identified Al-rich oxides formed on the surfaces of both specimens after the exposure with no lead penetration. Moreover, martensite, NiAl precipitates, and different carbides were observed in both alloys.
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| 10. |
- Enmar, Linda, et al.
(författare)
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A note on ADCP-based indirect observations of turbulence
- 2016
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Ingår i: Boreal environment research. - 1239-6095 .- 1797-2469. ; 21:1-2, s. 44-52
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Tidskriftsartikel (refereegranskat)abstract
- A 70-day data set from bottom-mounted ADCPs on the two sides of the Faroe-Bank Channel was analysed using the recorded flow variance and echo intensity in the deeper reaches of the passage as proxies for turbulence. A consistent picture emerged, not least since the data losses (which were ascribed to turbulence-induced activation of the fish-elimination option in the ADCP software) could be shown to co-vary with the internal M-2 tide affecting the vertical shear, which in turn proved to be correlated with the flow variance.
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