| 1. |
- Ahmed, Niaz, et al.
(författare)
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Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11-13 November 2018.
- 2019
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Ingår i: European Stroke Journal. - : SAGE Publications. - 2396-9873 .- 2396-9881. ; 4:4, s. 307-317
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the European Stroke Organisation-Karolinska Stroke Update Conference is to provide updates on recent stroke therapy research and to give an opportunity for the participants to discuss how these results may be implemented into clinical routine. The meeting started 22 years ago as Karolinska Stroke Update, but since 2014 it is a joint conference with European Stroke Organisation. Importantly, it provides a platform for discussion on the European Stroke Organisation guidelines process and on recommendations to the European Stroke Organisation guidelines committee on specific topics. By this, it adds a direct influence from stroke professionals otherwise not involved in committees and work groups on the guideline procedure. The discussions at the conference may also inspire new guidelines when motivated. The topics raised at the meeting are selected by the scientific programme committee mainly based on recent important scientific publications. This year's European Stroke Organisation-Karolinska Stroke Update Meeting was held in Stockholm on 11-13 November 2018. There were 11 scientific sessions discussed in the meeting including two short sessions. Each session except the short sessions produced a consensus statement (Full version with background, issues, conclusions and references are published as web-material and at www.eso-karolinska.org and http://eso-stroke.org) and recommendations which were prepared by a writing committee consisting of session chair(s), scientific secretary and speakers. These statements were presented to the 250 participants of the meeting. In the open meeting, general participants commented on the consensus statement and recommendations and the final document were adjusted based on the discussion from the general participants Recommendations (grade of evidence) were graded according to the 1998 Karolinska Stroke Update meeting with regard to the strength of evidence. Grade A Evidence: Strong support from randomised controlled trials and statistical reviews (at least one randomised controlled trial plus one statistical review). Grade B Evidence: Support from randomised controlled trials and statistical reviews (one randomised controlled trial or one statistical review). Grade C Evidence: No reasonable support from randomised controlled trials, recommendations based on small randomised and/or non-randomised controlled trials evidence.
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| 2. |
- Alfredsson, Magnus, et al.
(författare)
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Funktionskriterier för vägkonstruktioner : Förstudie
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Det projekt som här rapporteras har som syfte att identifiera och beskriva de svårigheter och möjligheter som totalentreprenader medför, respektive erbjuder, för alla parter. Målet är att utveckla totalentreprenader på ett sådant sätt att branschens effektivitet ökas. Denna rapport är en förstudie där det studerats vilka krav som byggherren ska ställa på utföraren av en vägkonstruktion i en totalentreprenad med funktionsansvar och hur utföraren ska verifiera kraven. Arbetet har genomförts med medlemmar från olika aktörer i branschen och omfattat främst litteraturstudier och intervjuer. Kunskaper och erfarenheter har sammanställts och analyserats för att slutligen kondenseras ned till ett antal förslag till fortsatt arbete.Förstudien har pekat ut ett antal områden som viktiga för att påskynda framtida utveckling av totalentreprenader:Terminologi – idag råder viss begreppsförvirringAnalys av funktionella krav i tidigare projektTrafikantkravMiljökravUtveckling av funktionella krav i samverkanVäghållarekonomiRegelbetingade begränsningar av funktionella kravUppföljning och underlättande av erfarenhetsackumuleringImplementering av nya mått och mätmetoder
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| 3. |
- Ekblad, Jonas, et al.
(författare)
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Impact on rutting from introduction of increased axle loads in Finland
- 2020
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Ingår i: The international journal of pavement engineering. - : Taylor and Francis Ltd.. - 1029-8436 .- 1477-268X.
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Tidskriftsartikel (refereegranskat)abstract
- In 2013, Finland introduced legislation increasing gross vehicle weights (GVW) on a number of trucks. Since the actual impact on road damage is nearly impossible to quantify in advance, the present analysis of road surface measurements is intended to provide knowledge regarding the impact on road damage. Rutting is influenced by many conflated phenomena. To indicate and capture the effect on road damage due to the new maximum GVW for certain truck- and trailer combinations, the analysis follows two different but mutually supporting lines of reasoning, empirical and theoretical, respectively. Analysis of measured rut depth is supported by theoretical calculations. Theoretical findings clearly indicate that the relative increase in road damage induced by higher GVW is larger than the increase in relative payload capacity. There was a rapid fleet shift towards heavier trucks after 2013, and statistical (empirical) analysis of road surface measurements shows an increase in rutting after this introduction.
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| 4. |
- Lundström, Robert, et al.
(författare)
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Fatigue modeling as related to flexible pavement design - State of the art
- 2007
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Ingår i: International Journal on Road Materials and Pavement Design. - : Informa UK Limited. - 1468-0629 .- 2164-7402. ; 8:2, s. 165-205
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Forskningsöversikt (refereegranskat)abstract
- A literature study of rheological and fatigue modeling of asphalt mixtures is presented. Theoretical aspects on structural modeling, rheological behavior and the fatigue integration in design procedures are reviewed In principle, pavement design methods can be categorized in three broad groups: empirical, semi-mechanistic and fully mechanistic methods. Pavement design is generally performed using semi-mechanistic methods comprising analytical or numerical structural response models and deterioration modeling based on transfer functions and shift factors. In the case of fatigue deterioration, several approaches have been elaborated e.g. classical models, fracture mechanics and damage mechanics. The approaches differ regarding theoretical foundation and evaluation methods used. Recognizing significant limitations concerning theoretical basis as well as lack of empirical support for current design methods, a shift in paradigm from semi-empirical methods towards more advanced fully mechanistic methods have been initiated. According to this approach, improved pavements are achieved by appropriate design methods which are capable of predicting fatigue resistance in the actual pavement environment, and thus taking into account complex stress conditions, influence of temperature and material characteristics, such as aging and healing.
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| 5. |
- Lundström, Robert, et al.
(författare)
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Influence of pavement materials on field performance : Evaluation of rutting on flexible semi-rigid and rigid test sections after 7 years of service
- 2009
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Ingår i: International Journal on Road Materials and Pavement Design. - : Informa UK Limited. - 1468-0629 .- 2164-7402. ; 10:4, s. 689-713
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents results obtained so far from a Swedish full-scale test, comprising in total 19 different rigid, semi-rigid and flexible test stretches. The purpose is to compare rutting performance of the different pavement categories and types using extensive laboratory tests and field measurements after seven years of trafficking. The rigid pavements withstand rutting better than the two other pavement categories due to comparably small abrasion and negligible permanent deformation. The semi-rigid pavements show less rutting than the flexible pavements, which primarily is the result of the negligible permanent deformation in the cement bound layers. Even though the rigid pavements show very small rutting, it is probably not the main distress type and the primary trigger for maintenance activities for this pavement type. In the case of semi-flexible and flexible pavements, both laboratory tests and field measurements indicate that significantly improved rutting performance can be obtained using appropriate asphalt mixtures manufactured using wear-resistant aggregates and stiff binder.
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| 6. |
- Tran, Thuy, 1980-, et al.
(författare)
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Real-Time Nanoplasmonic Sensor for IgG Monitoring in Bioproduction
- 2020
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Ingår i: Processes. - : MDPI. - 2227-9717. ; 8:10
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Tidskriftsartikel (refereegranskat)abstract
- Real-time monitoring of product titers during process development and production of biotherapeutics facilitate implementation of quality-by-design principles and enable rapid bioprocess decision and optimization of the production process. Conventional analytical methods are generally performed offline/at-line and, therefore, are not capable of generating real-time data. In this study, a novel fiber optical nanoplasmonic sensor technology was explored for rapid IgG titer measurements. The sensor combines localized surface plasmon resonance transduction and robust single use Protein A-modified sensor chips, housed in a flexible flow cell, for specific IgG detection. The sensor requires small sample volumes (1-150 mu L) and shows a reproducibility and sensitivity comparable to Protein G high performance liquid chromatography-ultraviolet (HPLC-UV). The dynamic range of the sensor system can be tuned by varying the sample volume, which enables quantification of IgG samples ranging from 0.0015 to 10 mg/mL, without need for sample dilution. The sensor shows limited interference from the sample matrix and negligible unspecific protein binding. IgG titers can be rapidly determined in samples from filtered unpurified Chinese hamster ovary (CHO) cell cultures and show good correlation with enzyme-linked immunosorbent assay (ELISA).
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| 10. |
- Auer, Renate, et al.
(författare)
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Measuring the Signs of H-1(alpha) Chemical Shift Differences Between Ground and Excited Protein States by Off-Resonance Spin-Lock R-1 rho NMR Spectroscopy
- 2009
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Ingår i: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 131:31, s. 10832-10833
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Tidskriftsartikel (refereegranskat)abstract
- Analysis of Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion NMR profiles provides the kinetics and thermodynamics of millisecond-time-scale exchange processes involving the interconversion of populated ground and invisible excited states. In addition, the absolute values of chemical, shift differences between NMR probes in the exchanging states, vertical bar Delta(pi)vertical bar, are also extracted. Herein, we present a simple experiment for obtaining the sign of H-1(alpha) Delta(pi) values by measuring off-resonance H-1(alpha) decay rates, R-1 rho, using weak proton spin-lock fields. A pair of R-1 rho values is measured with a spin-lock field applied vertical bar Delta omega vertical bar downfield and upfield of the major-state peak. In many cases, these two relaxation rates differ substantially, with the larger one corresponding to the case where the spin-lock field coincides with the resonance frequency of the probe in the minor state. The utility of the methodology is demonstrated first on a system involving protein ligand exchange and subsequently on an SH3 domain exchanging between a folded state and its on-pathway folding intermediate. With this experiment, it thus becomes possible to determine H-1(alpha) chemical shifts of the invisible excited state, which can be used as powerful restraints in defining the structural properties of these elusive conformers.
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