| 1. |
- McKay, James D., et al.
(författare)
-
A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
- 2011
-
Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 7:3
-
Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p <= 5 x 10(-7)). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1 x 10(-8)) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2 x 10(-8)) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 x 10(-8); rs1229984-ADH1B, p = 7 x 10(-9); and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
|
|
| 2. |
- Zhang, Xingxing, et al.
(författare)
-
The early design stage for building renovation with a novel loop-heat-pipe based solar thermal facade (LHP-STF) heat pump water heating system : Techno-economic analysis in three European climates
- 2015
-
Ingår i: Energy Conversion and Management. - : Elsevier BV. - 0196-8904 .- 1879-2227. ; 106, s. 964-986
-
Tidskriftsartikel (refereegranskat)abstract
- Most of the building renovation plans are usually decided in the early design stage. This delicate phase contains the greatest opportunity to achieve the high energy performance buildings after refurbishment. It is therefore important to provide the pertinent energy performance information for the designers or decision-makers from multidisciplinary and comparative points of view. This paper investigates the renovation concept of a novel loop-heat-pipe based solar thermal facade (LHP-STF) installed on a reference residential building by technical evaluation and economic analysis in three typical European climates, including North Europe (represented by Stockholm), West Europe (represented by London) and South Europe (represented by Madrid). The aim of this paper is firstly to explore the LHP-STF’s sensitivity with regards to the overall building socio-energy performance and secondly to study the LHP-STF’s economic feasibility by developing a dedicated business model. The reference building model was derived from the U.S. Department of Energy (DOE) commercial buildings research, in which the energy data for the building models were from the ASHRAE codes and other standard practices. The financial data were collected from the European statistic institute and the cost of system was based on the manufactured prototype. Several critical financial indexes were applied to evaluate the investment feasibility of the LHP-STF system in building renovation, such as Payback Period (PP), Net Present Value (NPV), and the modified internal rate of return method (IRR). Four common investment options were considered in this business model, including buying outright (BO), buying by instalment (BI), energy efficiency funding (EEF) and power purchase agreement (PPA). The research results indicate that the LHP-STF could contribute to the hot water load throughout the year with substantially reduced heating load in winter, and yet a slight increased cooling load in summer. Among four investment options, the BO was considered as the best investment method with the highest NPV, IRR and the shortest payback period. With regards to relatively limited solar resources, London was found to be the best place for investment with the highest economical revenues and an attractive payback period of less than four years for all purchase options. Although Madrid has the richest solar resource, this system has the lowest economic profit and the longest payback period. This outcome confirms that the renewable energy incentives have a higher impact than solar resources on current solar thermal facade technologies under such pricing fundamentals. This multidisciplinary research is expected to be helpful for the strategic decisions at the early design stage for building renovation with the proposed system and further promote development of solar driven service system, leading to the savings in fossil fuel consumption and reduction in carbon emission.
|
|
