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- Stolk, Jan, et al.
(författare)
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Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor
- 2012
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 40:2, s. 306-312
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Tidskriftsartikel (refereegranskat)abstract
- Palovarotene is an oral gamma-selective retinoid agonist. In animal emphysema models, palovarotene reduced inflammation, promoted structural repair and functional improvement. REPAIR (Retinoid treatment of Emphysema in Patients on the alpha(1)-antitrypsin International Registry), was an investigator-initiated, double-blind, placebo-controlled randomised study to assess the safety and efficacy of 5 mg.day(-1) palovarotene given for 1 year to 262 patients with severe alpha(1)-antitrypsin deficiency and emphysema confirmed by computed tomography. Change in volume-adjusted 15th percentile point lung density from baseline in 1 year was the primary endpoint; functional end-points were also regularly assessed. We randomly assigned 133 and 129 patients to placebo or palovarotene, respectively. Both groups were well matched for all baseline characteristics, including respiratory medications. 88% and 85% of patients completed 1 year of treatment with placebo and palovarotene, respectively. Palovarotene was generally well tolerated. In the study completers population, the placebo-corrected difference of lung density was -0.45 HU at week 28 (p=0.64) and -0.25 HU at week 52 (p=0.94). A nonsignificant treatment difference in most functional parameters of the lung in favour of the drug was observed over time suggesting potential pharmacological effects of palovarotene. Palovarotene 5 mg.day(-1) over 1 yr failed to show a significant benefit on lung density in moderate-to-severe emphysema secondary to severe alpha(1)-antitrypsin deficiency.
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| 2. |
- Kemper, M, et al.
(författare)
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Method for fractionating an aqueous paper fibre suspension and hydrocyclone for carrying out said method
- 2008
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Patent (populärvet., debatt m.m.)abstract
- The invention relates to a method and to a device which is used to fraction aqueous paper fibre suspensions (S). Relatively large centrifugal forces are used, also in suspension components having essentially the same densities, in order to achieve good results. This is achieved by virtue of the fact that the paper fibre suspension (S) entering via the inlet (10) is guided initially in a first annular chamber (4) which narrows in an axial direction (4) and subsequently in a second annular chamber (5) which widens in an axial direction. As a result, good fractionating results can be obtained, in particular, when the fibre material consistency in the inlet area is approximately 0.5 - 2 % and also the necessary mass fluxes are maintained at a relatively low level. Said method can be used, for example, for fractionating fresh cellulose and/or wood pulp. It can also be used in the preparation of used paper, wherein said method is particularly economical.
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