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Numrering	Referens	Omslagsbild	Hitta
1.	Kapelios, CJ, et al. (författare) Sacubitril/valsartan eligibility and outcomes in the ESC-EORP-HFA Heart Failure Long-Term Registry: bridging between European Medicines Agency/Food and Drug Administration label, the PARADIGM-HF trial, ESC guidelines, and real world 2019 Ingår i: European journal of heart failure. - : Wiley. - 1879-0844 .- 1388-9842. ; 21:11, s. 1383-1397 Tidskriftsartikel (refereegranskat)
2.	2017 swepub:Mat__t
3.	Wright, NJ, et al. (författare) Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study 2021 Ingår i: Lancet (London, England). - 1474-547X. ; 398:10297, s. 325-339 Tidskriftsartikel (refereegranskat)
4.	Herrera-Luis, E, et al. (författare) Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth 2022 Ingår i: Thorax. - 1468-3296. Tidskriftsartikel (refereegranskat)
5.	Herrera-Luis, E, et al. (författare) Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth 2023 Ingår i: Thorax. - : BMJ. - 1468-3296 .- 0040-6376. ; 78:3, s. 233-241 Tidskriftsartikel (refereegranskat)abstract In the USA, genetically admixed populations have the highest asthma prevalence and severe asthma exacerbations rates. This could be explained not only by environmental factors but also by genetic variants that exert ethnic-specific effects. However, no admixture mapping has been performed for severe asthma exacerbations.ObjectiveWe sought to identify genetic variants associated with severe asthma exacerbations in Hispanic/Latino subgroups by means of admixture mapping analyses and fine mapping, and to assess their transferability to other populations and potential functional roles.MethodsWe performed an admixture mapping in 1124 Puerto Rican and 625 Mexican American children with asthma. Fine-mapping of the significant peaks was performed via allelic testing of common and rare variants. We performed replication across Hispanic/Latino subgroups, and the transferability to non-Hispanic/Latino populations was assessed in 1001 African Americans, 1250 Singaporeans and 941 Europeans with asthma. The effects of the variants on gene expression and DNA methylation from whole blood were also evaluated in participants with asthma and in silico with data obtained through public databases.ResultsGenomewide significant associations of Indigenous American ancestry with severe asthma exacerbations were found at 5q32 in Mexican Americans as well as at 13q13-q13.2 and 3p13 in Puerto Ricans. The single nucleotide polymorphism (SNP) rs1144986 (C5orf46) showed consistent effects for severe asthma exacerbations across Hispanic/Latino subgroups, but it was not validated in non-Hispanics/Latinos. This SNP was associated withDPYSL3DNA methylation andSCGB3A2gene expression levels.ConclusionsAdmixture mapping study of asthma exacerbations revealed a novel locus that exhibited Hispanic/Latino-specific effects and regulatedDPYSL3andSCGB3A2.
6.	Pham, T, et al. (författare) Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study 2019 Ingår i: Anesthesiology. - : Lippincott Williams and Wilkins. - 1528-1175 .- 0003-3022. ; 130:2, s. 263-283 Tidskriftsartikel (refereegranskat)
7.	Bravo, L, et al. (författare) 2021 swepub:Mat__t
8.	Tabiri, S, et al. (författare) 2021 swepub:Mat__t

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Resultat 1-8 av 8

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Typ av publikation: tidskriftsartikel (5)

Typ av innehåll: refereegranskat (5)

Författare/redaktör: Santos, R. (4); Alameer, E (4); Martin, B. (3); Shaw, K. (3); Yang, H. (3); Morton, A. (3); visa fler...; Martin, S. (3); Jones, M. (3); Costa, M. (3); Williams, L. (3); Ali, M (3); Hassan, A (3); Pereira, A (3); Singh, A (3); Evans, J. (3); Wang, W. (3); Ghosh, D (3); Roberts, K (3); Patel, A (3); Arnaud, AP (3); Elhadi, M (3); Outani, O (3); Tabiri, S (3); Saad, MM (3); Ahmed, A (3); Bordoni, P (3); Baldini, E (3); Olori, S (3); Saleem, A (3); Ferreira, C (3); Saavedra, J (3); Gonzalez, J (3); Saleh, M (3); Martin, E (3); Williams, O (3); Mccluney, S (3); Vervoort, D (3); Navarro, A. (3); Jones, C (3); Thomas, M (3); Singh, B (3); Johnson, D. (3); Ismail, M (3); Badr, H. (3); Cao, H. (3); Ali, L (3); Park, C (3); Arshad, M. (3); Youssef, A. (3); Garcia, M (3); visa färre...

Lärosäte: Karolinska Institutet (7); Uppsala universitet (1); Linköpings universitet (1)

Språk: Engelska (8)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

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