| 1. |
- Jespersen, Henrik, et al.
(författare)
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Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.
- 2017
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Immune checkpoint inhibitors and adoptive cell transfer (ACT) of autologous tumor-infiltrating T cells have shown durable responses in patients with melanoma. To study ACT and immunotherapies in a humanized model, we have developed PDXv2.0 -a melanoma PDX model where tumor cells and tumor-infiltrating T cells from the same patient are transplanted sequentially in non-obese diabetic/severe combined immune-deficient/common gamma chain (NOG/NSG) knockout mouse. Key to T-cell survival/effect in this model is the continuous presence of interleukin-2 (IL-2). Tumors that grow in PDXv2.0 are eradicated if the autologous tumor cells and T cells come from a patient that exhibited an objective response to ACT in the clinic. However, T cells from patients that are non-responders to ACT cannot kill tumor cells in PDXv2.0. Taken together, PDXv2.0 provides the potential framework to further model genetically diverse human cancers for assessing the efficacy of immunotherapies as well as combination therapies.Combining different types of immune therapies might benefit certain patients. Here, the authors develop an autologous immune-humanized melanoma mouse model that allows the preclinical assessment of cancer cell-T cell interactions from each individual patient and the benefits of immunotherapies combinations.
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| 2. |
- Nilsson, Sheida, et al.
(författare)
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A retrospective clinical study of fixed tooth- and implant-supported prostheses in titanium and cobalt-chromium-ceramic: 5-9-year follow-up
- 2022
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Ingår i: Clinical Oral Investigations. - : Springer Science and Business Media LLC. - 1432-6981 .- 1436-3771. ; 26:10, s. 6097-6103
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Tidskriftsartikel (refereegranskat)abstract
- Objectives The aim of this retrospective study was to evaluate the clinical outcome of fixed tooth- and implant-supported protheses manufactured in porcelain veneered cobalt-chromium (CoCr) or titanium with a follow-up period of 5-9 years. Materials and methods This study included 63 patients with a total of 86 fixed dental protheses (FDPs) (53 implant-supported and 33 tooth-supported). In total, 67 were short-span FDPs (3-5 units) and 19 were long-span FDPs (6-12 units). The FDPs were evaluated using a modified version of the California Dental Association (CDA). Results The binary regression analysis indicated that neither CoCr nor titanium had a statistically significant effect on the odds of success or survival of either tooth- or implant-supported FDPs. However, the success of FDPs was negatively affected by greater FDP length and general tooth wear. The survival of FDPs was negatively affected by increased FDP longevity. Conclusions This study found no statistically significant effect on the odds of success and survival outcomes for any combination of tooth-supported, implant-supported, porcelain-veneered CoCr, or porcelain-veneered titanium FDPs. As the number of FDPs was limited, the results should be interpreted with caution.
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| 3. |
- Aktaş, Vezir, et al.
(författare)
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Gendered aspects of policies to fight the COVID-19 outbreak
- 2023
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Ingår i: Humanitas. - : Faculty of Arts and Sciences, Tekirdağ Namık Kemal University. - 2147-088X. ; 11:22, s. 42-64
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Tidskriftsartikel (refereegranskat)abstract
- Countries have taken different measures to limit the spread of COVID-19. However, it is unclear how such measures affect the daily lives of people in different cultural contexts. Using a qualitative research method and the framework of gender roles, this study analyzes the potential effects of the Turkish government’s policies to fight the COVID-19 pandemic on married men and women in Turkey. The respondents answered the open-ended questions developed by the researchers on the Google platform. 20 men (aged 27-54) and 20 women (aged 22-55) participated in the study. The respondents’ experiences were grouped into three themes: gender-related problems; adaptation and new habits/hobbies; and balancing between positive and negative effects. While men stressed the economic effects, women focused on social relations or deeper values of life. The findings were discussed within the framework of Gender Schema Theory and Social Role Theory.
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| 4. |
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| 5. |
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| 6. |
- Aktaş, Vezir, et al.
(författare)
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Social scientists under threat : Resistance and self-censorship in Turkish academia
- 2019
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Ingår i: British Journal of Educational Studies. - : Taylor & Francis. - 0007-1005 .- 1467-8527. ; 67:2, s. 169-186
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Tidskriftsartikel (refereegranskat)abstract
- Attacks on academic freedom in Turkey have become increasingly systematic in recent years and thousands of academics have been dismissed. This study reflects on the effects of this worsening repression through interviews with academics in the social sciences, both those dismissed and those still active in their profession. Although the dismissed academics are socially in a very precarious position, they are continuing their scholarly activities in alternative, underground forms. This resistance stands in contrast to the accommodation and self-censorship that seem, according to the interviewees, to prevail in university departments.
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| 7. |
- Aktaş, Vezir, et al.
(författare)
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Taking to the streets : A study of the street academy in Ankara
- 2020
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Ingår i: British Journal of Educational Studies. - : Taylor & Francis. - 0007-1005 .- 1467-8527. ; 68:3, s. 365-388
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Tidskriftsartikel (refereegranskat)abstract
- In wide-ranging attacks on academic freedom in Turkey in recent years, thousands of academics have lost their university positions. At the end of 2016 oppositional academics, many of whom were dismissed from their positions for having signed a peace petition, established a Street Academy as an alternative way to reach out to both students and the public in Ankara. In this study we analyse the experiences of these street academy lecturers from the perspective of Social Representation Theory. Our main aims were to explore teaching experience perceptions and representations and, in addition, also the opportunities and challenges generated by this alternative academy. Data consisted of semi-structured interviews with five female and five male street academy lecturers. The results of a qualitative thematic analysis revealed that the way participants explained their experiences could be organised into three major themes and several subordinate themes. One of the most salient results was that participating in the street Academy had become a way to defend academic freedom. More generally suggested results demonstrated that teaching in this new setting, outside of the universities and away from customised learning environments, was quite a novel experience. The possible implications of street academy lecturers? experiences are discussed.
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| 8. |
- Bajramović, R. Č, et al.
(författare)
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Identity management by multiple identification : religious leaders and EU integration of Bosnia and Herzegovina
- 2024
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Ingår i: Journal of Contemporary European Studies. - : Taylor & Francis. - 1478-2804 .- 1478-2790.
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Tidskriftsartikel (refereegranskat)abstract
- This research examines the identity management strategies among Bosnian religious leaders belonging to the three major religious groups in Bosnia and Herzegovina (B&H), namely the Islamic Community, the Serbian Orthodox Church, and the Roman Catholic Archdiocese of Vrhbosna. The research is based on 31 semi-structured interviews conducted with religious leaders from the aforementioned groups. It specifically focuses on how religious leaders manage negative in-group identities in the context of the country’s EU integration process. Identity management strategies described in the previous literature cannot explain how the respondents in the post-conflict environment of B&H deal with negative in-group perceptions. Instead, this research identifies a new strategy: multiple identification, i.e. identifying not only with the in-group but also with an out-group, thereby paving the way for a novel approach to identity management through multiple group affiliations, emphasizing shared values. With the help of thematic analysis, the article demonstrates how multiple identification with both the in-group and the perceived European society as an out-group evolves in this empirical case.
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| 9. |
- Bergquist, Annika, et al.
(författare)
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Impact on follow-up strategies in patients with primary sclerosing cholangitis
- 2023
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Ingår i: Liver international (Print). - Chichester, United Kingdom : Wiley-Blackwell Publishing Inc.. - 1478-3223 .- 1478-3231. ; 43:1, s. 127-138
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Evidence for the benefit of scheduled imaging for early detection of hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow-up strategies in PSC with the hypothesis that regular imaging improves survival.METHODS: We collected retrospective data from 2,975 PSC patients from 27 centers. Patients were followed from the start of scheduled imaging or in case of clinical follow-up from January 1, 2000, until death or last clinical follow-up alive. The primary endpoint was all-cause mortality.RESULTS: A broad variety of different follow-up strategies were reported. All except one center used regular imaging, ultrasound (US) and/or magnetic resonance imaging (MRI). Two centers used scheduled ERCP in addition to imaging for surveillance purposes. The overall HR (CI95%) for death, adjusted for sex, age and start year of follow-up, were 0.61 (0.47-0.80) for scheduled imaging with and without ERCP; 0.64 (0.48-0.86) for US/MRI and 0.53 (0.37-0.75) for follow-up strategies including scheduled ERCP. The lower risk of death remained for scheduled imaging with and without ERCP after adjustment for cholangiocarcinoma (CCA) or high-grade dysplasia as a time-dependent covariate, HR 0.57 (0.44-0.75). Hepatobiliary malignancy was diagnosed in 175 (5.9%) of the patients at 7.9 years follow-up. Asymptomatic patients (25%) with CCA had better survival if scheduled imaging had been performed.CONCLUSIONS: Follow-up strategies vary considerably across centers. Scheduled imaging was associated with improved survival. Multiple factors may contribute to this result including early tumor detection and increased endoscopic treatment of asymptomatic benign biliary strictures.
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| 10. |
- Borell, Klas, 1950-, et al.
(författare)
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Debatt: Samhällsvetenskaperna och den akademiska friheten i Turkiet : Massavskedanden, resignation och motstånd
- 2019
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Ingår i: Sociologisk forskning. - Lund : Sveriges Sociologförbund. - 0038-0342 .- 2002-066X. ; 56:3-4, s. 311-317
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Allvarliga kränkningar av den akademiska friheten förekommer idag i flera av Europarådets medlemsstater och det är ofta samhällsvetenskaperna som utgör måltavlan. Situationen är särskilt allvarlig i Turkiet där tusentals universitetslärare avskedats. Intervjuer med avskedade turkiska samhällsvetare och samhällsvetare som lever under hot om avsked ger en sammansatt bild: här finns både resignation och motstånd.
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