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- Bousquet, J, et al.
(författare)
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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
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Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
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Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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- Bousquet, J., et al.
(författare)
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Building Bridges for Innovation in Ageing : Synergies between Action Groups of the EIP on AHA
- 2017
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Ingår i: The Journal of Nutrition, Health & Aging. - : Springer Nature. - 1279-7707 .- 1760-4788. ; 21:1, s. 92-104
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Tidskriftsartikel (refereegranskat)abstract
- The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
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- Kampessis, G, et al.
(författare)
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Prospective Study on the Effectiveness of Low-Laser Therapy in the Treatment of Tinnitus
- 2009
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Ingår i: Skull base. - : Georg Thieme Verlag. - 1052-1453 .- 1532-0065 .- 1531-5010. ; 19:S 02
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Tidskriftsartikel (refereegranskat)abstract
- Background and Aim: It is estimated that 10–15% of the general population suffers from tinnitus, including 60% of all otologic patients. Quality of life is reportedly affected in approximately 0.5% of tinnitus patients. The aim of this study is to investigate the role of low-laser therapy in alleviating the symptoms of tinnitus.Material and Methods: Seventeen tinnitus patients (8 men, 9 women) were included in the study. Tinnitus was identified by the patients either as their sole complaint, or as symptom within the context of other otologic diseases. A 0–5 Visual Analogue Scale (VAS) was used to personally quantify the severity of patients' symptoms. Treatment included the use of an external laser beam in the periauricular area and the external auditory canal, which was produced either by a GaAlAs (808 nm, 450 mW), or by a GaAs (904 nm, 240 mW) laser, for 4 and 2 minutes, respectively. The mean number of sessions for each patient was 17, and the mean duration of therapy was 4 weeks.Results: With regard to the severity of symptoms, the pretreatment mean score was 4.3, and the respected number after the intervention was 3.2. There was a consistent trend toward symptom improvement; however, the results were not statistically significant due to the small sample size. No side effects or deterioration of symptoms was reported.Conclusion: Low-laser therapy does seem to have some effect in alleviating tinnitus. However, additional studies are necessary to prove the actual efficacy of this treatment mode and to establish superior outcomes compared with placebo.
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- Papanikolaou, E., et al.
(författare)
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Implicit business model effects of DLT adoption
- 2021
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Ingår i: Procedia CIRP. - : Elsevier BV. - 2212-8271. ; , s. 298-304
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Konferensbidrag (refereegranskat)abstract
- The significance of supply chain collaboration, communication and data exchange along with the importance of the relationships established among interconnected parties in a digital connected world, indicates the power of Distributed Ledger Technology (DLT) to transform the business model. In our study we set out to advance our understanding on how DLT impacts the business model. Since DLT is in its primitive stage of development, most studies focus into the implementation aspect of the technology and limited research has been done into the business model implications. Our research closes that knowledge gap in the literature by answering the question of "What are the secondary effects in business model that stem from DLT adoption?"Due to the inherent characteristics of the DLT, in respect to its network facet and the network effects created, we argue for a business ecosystem approach for our research. The main contributions of this paper are twofold. It presents implicit effects on business model beyond the direct trust and data openness aspects, and it also provides managers and scholars a process model for assessing how each implicit effect impacts the various business model dimensions.
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