| 1. |
- Lind, Mikael, et al.
(författare)
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Punctuality as performance metrics for efficient transportation systems
- 2014
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Ingår i: 21st World Congress on Intelligent Transport Systems, ITSWC 2014. - : Intelligent Transport Systems (ITS).
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Konferensbidrag (refereegranskat)abstract
- Transportation systems are ecosystems building on a high degree of co-production of value performed by multiple actors. In order to guide involved actors and ensure expected performance it becomes necessary to have an agreed performance metrics. Beside operational capacity for the transportation systems as such it is believed that punctuality as a performance metrics would be a solid base enabling different actors to take appropriate actions in planning, realizing, and evaluating their actions in relation to the expectations among involved actors (including beneficiaries) of the transportation system. In this paper, underlying mechanisms for punctuality are explored as the basis for an efficient transportation system.
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| 2. |
- Linge, Jennifer, et al.
(författare)
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Adverse muscle composition predicts all-cause mortality in the UK Biobank imaging study
- 2021
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Ingår i: Journal of Cachexia, Sarcopenia and Muscle. - : Wiley. - 2190-5991 .- 2190-6009. ; 12:6, s. 1513-1526
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Tidskriftsartikel (refereegranskat)abstract
- Background Adverse muscle composition (MC) as measured by magnetic resonance imaging has previously been linked to poor function, comorbidity, and increased hospitalization. The aim of this study was to investigate if adverse MC predicts all-cause mortality using data from UK Biobank. Methods There were 40 178 participants scanned using a 6 min magnetic resonance imaging protocol. Images were analysed for thigh fat-tissue free muscle volume and muscle fat infiltration (MFI) using AMRA (R) Researcher (AMRA Medical, Linkoping, Sweden). For each participant, a sex, weight, and height invariant muscle volume z-score was calculated. Participants were partitioned into four MC groups: (i) normal MC, (ii) only low muscle volume [<25th percentile for muscle volume z-score (population wide)], (iii) only high MFI [>75th percentile (population wide, sex-specific)], and (iv) adverse MC (low muscle volume z-score and high MFI). Association of MC groups with mortality was investigated using Cox proportional-hazard modelling with normal MC as referent (unadjusted and adjusted for low hand grip strength, sex, age, body mass index, previous diagnosis of disease (cancer, type 2 diabetes and coronary heart disease), lifestyle, and socioeconomic factors (smoking, alcohol consumption, physical activity, and Townsend deprivation index). Results Muscle composition measurements were complete for 39 804 participants [52% female, mean (SD) age 64.2 (7.6) years and body mass index 26.4 (4.4) kg/m(2)]. Three hundred twenty-eight deaths were recorded during a follow-up period of 2.9 (1.4) years after imaging. At imaging, adverse MC was detected in 10.5% of participants. The risk of death from any cause in adverse MC compared with normal MC was 3.71 (95% confidence interval 2.81-4.91, P < 0.001). Only low muscle volume and only high MFI were independently associated with all-cause mortality [1.58 (1.13-2.21), P = 0.007, and 2.02 (1.51-2.71), P < 0.001, respectively]. Adjustment of low hand grip strength [1.77 (1.28-2.44), P < 0.001] did not attenuate the associations with any of the MC groups. In the fully adjusted model, adverse MC and only high MFI remained significant (P P = 0.020) while the association with only low muscle volume was attenuated to non-significance (P = 0.560). The predictive performance of adverse MC [1.96 (1.42-2.71), P < 0.001] was comparable with that of previous cancer diagnosis [1.93 (1.47-2.53), P < 0.001] and smoking [1.71 (1.02-2.84), P = 0.040]. Low hand grip strength was borderline non-significant [1.34 (0.96-1.88), P = 0.090]. Conclusions Adverse MC was a strong and independent predictor of all-cause mortality. Sarcopenia guidelines can be strengthened by including cut-offs for myosteatosis enabling detection of adverse MC.
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| 3. |
- Adamsson, Mathias, et al.
(författare)
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A holistic approach for a natural light variation experience : a pilot study of a practical application for office lighting
- 2019
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Konferensbidrag (refereegranskat)abstract
- Lighting is crucial for vision and has important effects beyond vision, influencing a variety of physiological and behavioral processes. When designing lighting, visual aspects, effects beyond vision, and perception of the environment should be considered together in a holistic approach. As humans evolved under daylight, a lighting protocol, based on a room context and daylight characteristics, was developed and described. The lighting, with customized light levels, spectral composition and light distribution that changed dynamically to evoke a perception of daylight conditions, was realized using commercially available luminaires and a digital control system. The resulting lighting conditions are described by measurements.
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| 4. |
- Andersson, Magnus, et al.
(författare)
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Fiskbestånd och miljö i hav och sötvatten : Resurs- och miljööversikt 2012
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Detta är den nionde utgåvan av den samlade översikten över fisk- och kräftdjursbeståndens status i våra vatten. Kunskap om fiskbestånden och miljön är en förutsättning för att utnyttjandet av fiskresurserna skall bli bärkraftigt. För svenska vattenområden beskrivs miljöutvecklingen i ett ekosystemsperspektiv, dels för att tydliggöra fiskens ekologiska roll och beskriva yttre miljöfaktorer som påverkar fiskbestånden, dels för att belysa fiskets effekter på miljön.Fiskbestånd och miljö i hav och sötvatten är utarbetad av Sveriges lantbruksuniversitet (SLU), Institutionen för akvatiska resurser (SLU Aqua), på uppdrag av Havs- och vattenmyndigheten. Rapporten sammanfattar utveckling och beståndsstatus för de kommersiellt viktigaste fisk- och kräftdjursarterna i våra vatten. Bedömningar och förvaltningsråd är baserade på Internationella Havsforskningsrådets (ICES) rådgivning, SLU Aquas nationella och regionala provfiskedata, samt yrkesfiskets rapportering.
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| 5. |
- Björck, Viveka, et al.
(författare)
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Morbidity and mortality in critically ill patients with invasive group A streptococcus infection : an observational study
- 2020
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Ingår i: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Group A streptococci (GAS) are known to cause serious invasive infections, but little is known about outcomes when patients with these infections are admitted to intensive care. We wanted to describe critically ill patients with severe sepsis or septic shock due to invasive GAS (iGAS) and compare them with other patients with severe sepsis or septic shock. METHODS: Adult patients admitted to a general intensive care unit (ICU) in Sweden (2007-2019) were screened for severe sepsis or septic shock according to Sepsis 2 definition. Individuals with iGAS infection were identified. The outcome variables were mortality, days alive and free of vasopressors and invasive mechanical ventilation, maximum acute kidney injury score for creatinine, use of continuous renal replacement therapy and maximum Sequential Organ Failure Assessment score during the ICU stay. Age, Simplified Acute Physiology Score (SAPS 3) and iGAS were used as independent, explanatory variables in regression analysis. Cox regression was used for survival analyses. RESULTS: iGAS was identified in 53 of 1021 (5.2%) patients. Patients with iGAS presented a lower median SAPS 3 score (62 [56-72]) vs 71 [61-81]), p < 0.001), had a higher frequency of cardiovascular cause of admission to the ICU (38 [72%] vs 145 [15%], p < 0.001) and had a higher median creatinine score (173 [100-311] vs 133 [86-208] μmol/L, p < 0.019). Of the GAS isolates, 50% were serotyped emm1/T1 and this group showed signs of more pronounced circulatory and renal failure than patients with non-emm1/T1 (p = 0.036 and p = 0.007, respectively). After correction for severity of illness (SAPS 3) and age, iGAS infection was associated with lower mortality risk (95% confidence interval (CI) of hazard ratio (HR) 0.204-0.746, p < 0.001). Morbidity analyses demonstrated that iGAS patients were more likely to develop renal failure. CONCLUSION: Critically ill patients with iGAS infection had a lower mortality risk but a higher degree of renal failure compared to similarly ill sepsis patients. emm1/T1 was found to be the most dominant serotype, and patients with emm1/T1 demonstrated more circulatory and renal failure than patients with other serotypes of iGAS.
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| 6. |
- Cariou, Bertrand, et al.
(författare)
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Effect of tirzepatide on body fat distribution pattern in people with type 2 diabetes
- 2024
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Ingår i: Diabetes, obesity and metabolism. - : WILEY. - 1462-8902 .- 1463-1326.
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Tidskriftsartikel (refereegranskat)abstract
- AimsTo describe the overall fat distribution patterns independent of body mass index (BMI) in participants with type 2 diabetes (T2D) in the SURPASS-3 MRI substudy by comparison with sex- and BMI-matched virtual control groups (VCGs) derived from the UK Biobank imaging study at baseline and Week 52. MethodsFor each study participant at baseline and Week 52 (N = 296), a VCG of >= 150 participants with the same sex and similar BMI was identified from the UK Biobank imaging study (N = 40 172). Average visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (aSAT) and liver fat (LF) levels and the observed standard deviations (SDs; standardized normal z-scores: z-VAT, z-aSAT and z-LF) were calculated based on the matched VCGs. Differences in z-scores between baseline and Week 52 were calculated to describe potential shifts in fat distribution pattern independent of weight change. ResultsBaseline fat distribution patterns were similar across pooled tirzepatide (5, 10 and 15 mg) and insulin degludec (IDeg) arms. Compared with matched VCGs, SURPASS-3 participants had higher baseline VAT (mean [SD] z-VAT +0.42 [1.23]; p < 0.001) and LF (z-LF +1.24 [0.92]; p < 0.001) but similar aSAT (z-aSAT -0.13 [1.11]; p = 0.083). Tirzepatide-treated participants had significant decreases in z-VAT (-0.18 [0.58]; p < 0.001) and z-LF (-0.54 [0.84]; p < 0.001) but increased z-aSAT (+0.11 [0.50]; p = 0.012). Participants treated with IDeg had a significant change in z-LF only (-0.46 [0.90]; p = 0.001), while no significant changes were observed for z-VAT (+0.13 [0.52]; p = 0.096) and z-aSAT (+0.09 [0.61]; p = 0.303). ConclusionIn this exploratory analysis, treatment with tirzepatide in people with T2D resulted in a significant reduction of z-VAT and z-LF, while z-aSAT was increased from an initially negative value, suggesting a possible treatment-related shift towards a more balanced fat distribution pattern with prominent VAT and LF loss.
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| 7. |
- Dobsicek Trefna, Hana, 1979, et al.
(författare)
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Multifrequency approach in hyperthermia treatment planning: Impact of frequency on SAR distribution in head and neck
- 2017
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Ingår i: 2017 11th European Conference on Antennas and Propagation, EUCAP 2017. ; , s. 3710-3712
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Konferensbidrag (refereegranskat)abstract
- Addition of hyperthermia to radiotherapy has been shown beneficial in management of many types of cancer [1], including Head and Neck tumors [2]. The objective of hyperthermia treatment is to raise the temperature in the tumor to a therapeutic level 40-44°C for typically 60 minutes to achieve cell death or render the cells more sensitive to ionizing radiation and chemical toxins. In our work, we aim to develop H&N applicator that is capable of modifying the focus size according to tumor position and volume. The system consists of a number of antennas placed around a patient, relying on a constructive wave interference to selectively heat the tumour. The spatial control of the foci spot and thus the quality of hyperthermia treatment can be controled by varying operational frequency in addition to amplitude and phase optimization. Due to different wavelengths, treatment associated hot spots often appear at different locations. In conjunction with cooling effect of the blood, the multi-frequency system have potential to achieve higher tumor temperature with 'same' constraints on hot spots. In this paper we investigated if combination of treatment plans utilizing sequential application of various frequencies is superior to the heating with single frequency settings.
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| 8. |
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| 9. |
- Fischer, Martin, et al.
(författare)
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SPASS : Strengthen Performance Active Safety Simulator
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The aim of the SPASS project was to evaluate early development/rapid prototyping of new driver assistance systems by utilizing an advanced driving simulator in combination with a vehicle electrical architecture (including sensors, actuators and HMI). As a case study, the project demonstrated a novel active safety function which was rather well penetrated at Volvo Car Corporation (VCC), i.e. VCC had reference vehicles up and running. The project used VTI’s advanced driving simulator (Sim IV) in Gothenburg to establish a simulator platform for evaluation of driver-system interaction. The objective was to understand the capability of Sim IV when studying active safety functions requiring interaction between road infrastructure, sensors, electrical architecture, actuators and Human-Machine Interaction, and to understand how useful Sim IV is during the ordinary concept development phase at vehicle manufacturers. Warning systems that act when the driver is on the way to unintentionally leave the lane are already available today. The next generation of systems will not only warn the driver but will actively contribute to the steering task. One such system is VCC’s eLKA (emergency lane keeping assistance). As part of the SPASS project a scenario which lead to triggering of the eLKA function was developed and tested. The scenario consisted of rural road driving where drivers were distracted by means of a visual distraction task (reading numbers from a screen, placed at a relative large down angle relative to the view of the forward roadway) and then poured across the median towards an oncoming vehicle by introducing an additional steering angle in the simulated vehicle. An integrated test environment for active safety functions has been developed and evaluated. VCC’s emergency lane keeping assistance system (eLKA) has been used as test case in the evaluation, and the functioning of the eLKA has been validated and approved by experts at VCC.
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| 10. |
- Flygare, Lennart, et al.
(författare)
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Cartilage matrix macromolecules in lavage fluid of temporomandibular joints before and 6 months after diskectomy
- 1997
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Ingår i: European Journal of Oral Sciences. - : Wiley-Blackwell. - 0909-8836 .- 1600-0722. ; 105:4, s. 369-372
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Tidskriftsartikel (refereegranskat)abstract
- The purpose was to investigate if antigenic fragments of aggrecan and cartilage oligomeric matrix protein (COMP) are detectable by enzyme-linked immunosorbent assay in lavage fluids from the temporomandibular joint (TMJ) and to examine if the relative content of these cartilage markers changes during development of osteoarthrosis (OA) after diskectomy. Lavage fluid was obtained at surgery and 6 months postoperatively in 13 patients. Computed tomography or magnetic resonance imaging was without evidence of hard-tissue changes prior to surgery in all patients. In 9 of the patients, sufficient material for analysis was obtained at both examinations. Aggrecan and COMP were detectable in all but 2 fluids, in which the COMP levels were below detection limit. The aggrecan/COMP ratio increased in all 9 patients during the 6-month period, indicating increased release of aggrecan relative to COMP fragments. The changed aggrecan/COMP ratio possibly reflects increased cartilage turnover during development of OA. Changes compatible with OA were present on computed tomography in all cases at the 6-month follow-up. This study shows that the lavage procedure is feasible for obtaining synovial fluid from the TMJ for immunochemical analyses of tissue-derived macromolecules.
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