↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Priami C) "

Sökning: WFRF:(Priami C)

Resultat 1-2 av 2

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	Allen, GI, et al. (författare) Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease 2016 Ingår i: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 12:6, s. 645-653 Tidskriftsartikel (refereegranskat)
2.	Caberlotto, L, et al. (författare) Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases 2019 Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 3965- Tidskriftsartikel (refereegranskat)abstract Evidence is accumulating that the main chronic diseases of aging Alzheimer’s disease (AD) and type-2 diabetes mellitus (T2DM) share common pathophysiological mechanisms. This study aimed at applying systems biology approaches to increase the knowledge of the shared molecular pathways underpinnings of AD and T2DM. We analysed transcriptomic data of post-mortem AD and T2DM human brains to obtain disease signatures of AD and T2DM and combined them with protein-protein interaction information to construct two disease-specific networks. The overlapping AD/T2DM network proteins were then used to extract the most representative Gene Ontology biological process terms. The expression of genes identified as relevant was studied in two AD models, 3xTg-AD and ApoE3/ApoE4 targeted replacement mice. The present transcriptomic data analysis revealed a principal role for autophagy in the molecular basis of both AD and T2DM. Our experimental validation in mouse AD models confirmed the role of autophagy-related genes. Among modulated genes, Cyclin-Dependent Kinase Inhibitor 1B, Autophagy Related 16-Like 2, and insulin were highlighted. In conclusion, the present investigation revealed autophagy as the central dys-regulated pathway in highly co-morbid diseases such as AD and T2DM allowing the identification of specific genes potentially involved in disease pathophysiology which could become novel targets for therapeutic intervention.

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-2 av 2

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Caberlotto, L (2); Xie, Y. (1); Lee, E. (1); Das, S. (1); Bennett, DA (1); Bellotti, R. (1); visa fler...; Hwang, J (1); Xu, J (1); Klein, A (1); Ghosh, SS (1); Simmons, A. (1); Green, RC (1); Lovestone, S (1); Weiner, MW (1); Xie, L. (1); Krause, R. (1); Peters, MA (1); Mangravite, LM (1); Boutros, PC (1); Cedazo-Minguez, A (1); Shen, X (1); Maioli, S (1); Allen, GI (1); Amoroso, N (1); Anghel, C (1); Balagurusamy, V (1); Bare, CJ (1); Beaton, D (1); Boehme, KL (1); Caloian, C (1); Campbell, F (1); Neto, EC (1); Chang, YC (1); Chen, BB (1); Chen, CY (1); Chien, TY (1); Clark, T (1); Davatzikos, C (1); Deng, JY (1); Dillenberger, D (1); Dobson, RJB (1); Dong, QL (1); Doshi, J (1); Duma, D (1); Errico, R (1); Erus, G (1); Everett, E (1); Fardo, DW (1); Friend, SH (1); Frohlich, H (1); visa färre...

Lärosäte: Karolinska Institutet (2)

Språk: Engelska (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy