| 1. |
- Carraminana, Albert, et al.
(författare)
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Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
- 2019
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Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - : W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.
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| 2. |
- Kleinteich, Julia, et al.
(författare)
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Pole-to-Pole Connections : Similarities between Arctic and Antarctic Microbiomes and Their Vulnerability to Environmental Change
- 2017
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Ingår i: Frontiers in Ecology and Evolution. - : FRONTIERS MEDIA SA. - 2296-701X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- The global biogeography of microorganisms remains poorly resolved, which limits the current understanding of microbial resilience toward environmental changes. Using high-throughput 16S rRNA gene amplicon sequencing, we characterized the microbial diversity of terrestrial and lacustrine biofilms from the Arctic, Antarctic and temperate regions. Our analyses suggest that bacterial community compositions at the poles are more similar to each other than they are to geographically closer temperate habitats, with 32% of all operational taxonomic units (OTUs) co-occurring in both polar regions. While specific microbial taxa were confined to distinct regions, representing potentially endemic populations, the percentage of cosmopolitan taxa was higher in Arctic (43%) than in Antarctic samples (36%). The overlap in polar microbial OTUs may be explained by natural or anthropogenically-mediated dispersal in combination with environmental filtering. Current and future changing environmental conditions may enhance microbial invasion, establishment of cosmopolitan genotypes and loss of endemic taxa.
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| 3. |
- Ferrando, Carlos, et al.
(författare)
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Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy : a randomised controlled trial
- 2020
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Ingår i: British Journal of Anaesthesia. - : ELSEVIER SCI LTD. - 0007-0912 .- 1471-6771. ; 124:1, s. 110-120
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to examine whether using a high fraction of inspired oxygen (FIO2) in the context of an individualised intra- and postoperative open-lung ventilation approach could decrease surgical site infection (SSI) in patients scheduled for abdominal surgery. Methods: We performed a multicentre, randomised controlled clinical trial in a network of 21 university hospitals from June 6, 2017 to July 19, 2018. Patients undergoing abdominal surgery were randomly assigned to receive a high (0.80) or conventional (0.3) FIO2 during the intraoperative period and during the first 3 postoperative hours. All patients were mechanically ventilated with an open-lung strategy, which included recruitment manoeuvres and individualised positive end-expiratory pressure for the best respiratory-system compliance, and individualised continuous postoperative airway pressure for adequate peripheral oxyhaemoglobin saturation. The primary outcome was the prevalence of SSI within the first 7 postoperative days. The secondary outcomes were composites of systemic complications, length of intensive care and hospital stay, and 6-month mortality. Results: We enrolled 740 subjects: 371 in the high FIO2 group and 369 in the low FIO2 group. Data from 717 subjects were available for final analysis. The rate of SSI during the first postoperative week did not differ between high (8.9%) and low (9.4%) FIO2 groups (relative risk [RR]: 0.94; 95% confidence interval [CI]: 0.59-1.50; P=0.90]). Secondary outcomes, such as atelectasis (7.7% vs 9.8%; RR: 0.77; 95% CI: 0.48-1.25; P=0.38) and myocardial ischaemia (0.6% [n=2] vs 0% [n=0]; P=0.47) did not differ between groups. Conclusions: An oxygenation strategy using high FIO2 compared with conventional FIO2 did not reduce postoperative SSIs in abdominal surgery. No differences in secondary outcomes or adverse events were found.
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| 4. |
- Huaraca Huasco, Walter, et al.
(författare)
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Fine root dynamics across pantropical rainforest ecosystems
- 2021
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Ingår i: Global Change Biology. - : John Wiley & Sons. - 1354-1013 .- 1365-2486. ; 27:15, s. 3657-3680
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Tidskriftsartikel (refereegranskat)abstract
- Fine roots constitute a significant component of the net primary productivity (NPP) of forest ecosystems but are much less studied than aboveground NPP. Comparisons across sites and regions are also hampered by inconsistent methodologies, especially in tropical areas. Here, we present a novel dataset of fine root biomass, productivity, residence time, and allocation in tropical old-growth rainforest sites worldwide, measured using consistent methods, and examine how these variables are related to consistently determined soil and climatic characteristics. Our pantropical dataset spans intensive monitoring plots in lowland (wet, semi-deciduous, and deciduous) and montane tropical forests in South America, Africa, and Southeast Asia (n = 47). Large spatial variation in fine root dynamics was observed across montane and lowland forest types. In lowland forests, we found a strong positive linear relationship between fine root productivity and sand content, this relationship was even stronger when we considered the fractional allocation of total NPP to fine roots, demonstrating that understanding allocation adds explanatory power to understanding fine root productivity and total NPP. Fine root residence time was a function of multiple factors: soil sand content, soil pH, and maximum water deficit, with longest residence times in acidic, sandy, and water-stressed soils. In tropical montane forests, on the other hand, a different set of relationships prevailed, highlighting the very different nature of montane and lowland forest biomes. Root productivity was a strong positive linear function of mean annual temperature, root residence time was a strong positive function of soil nitrogen content in montane forests, and lastly decreasing soil P content increased allocation of productivity to fine roots. In contrast to the lowlands, environmental conditions were a better predictor for fine root productivity than for fractional allocation of total NPP to fine roots, suggesting that root productivity is a particularly strong driver of NPP allocation in tropical mountain regions.
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| 5. |
- Jesus Garcia-Pereira, Maria, et al.
(författare)
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Impact of deep coalescence and recombination on the estimation of phylogenetic relationships among species using AFLP markers
- 2014
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Ingår i: Molecular Phylogenetics and Evolution. - : Elsevier BV. - 1055-7903 .- 1095-9513. ; 76, s. 102-109
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Tidskriftsartikel (refereegranskat)abstract
- Deep coalescence and the nongenealogical pattern of descent caused by recombination have emerged as a common problem for phylogenetic inference at the species level. Here we use computer simulations to assess whether AFLP-based phylogenies are robust to the uncertainties introduced by these factors. Our results indicate that phylogenetic signal can prevail even in the face of extensive deep coalescence allowing recovering the correct species tree topology. The impact of recombination on tree accuracy was related to total tree depth and species effective population size. The correct tree topology could be recovered upon many simulation settings due to a trade-off between the conflicting signals resulting from intra-locus recombination and the benefits of the joint consideration of unlinked loci that better matched overall the true species tree. Errors in tree topology were not only determined by deep coalescence, but also by the timing of divergence and the tree-building errors arising from an insufficient number of characters. DNA sequences generally outperformed AFLPs upon any simulated scenario, but this difference in performance was nearly negligible when a sufficient number of AFLP characters were sampled. Our simulations suggest that the impact of deep coalescence and intra-locus recombination on the reliability of AFLP trees could be minimal for effective population sizes equal to or lower than 10,000 (typical of many vertebrates and tree plants) given tree depths above 0.02 substitutions per site.
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| 6. |
- Lockett, Nigel, et al.
(författare)
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‘Lost in Space’: The Role of Social Networking in University-based Entrepreneurial Learning
- 2017
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Ingår i: Industry & higher education. - : SAGE Publications. - 0950-4222 .- 2043-6858. ; 31:2, s. 67-80
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Tidskriftsartikel (refereegranskat)abstract
- While entrepreneurship education increasingly uses various means to connect students to the ‘real world’, the impact of social networking on learning remains under-explored. This qualitative study of student entrepreneurs in UK and Sweden shows that their entrepreneurial journey becomes increasingly complex, requiring skills and knowledge not solely developed through formal or non-formal learning. Social networks, and associated informal learning, are shown to be critical in developing social capital important to the students’ entrepreneurial journey. This study exposes a key value of social networking and encourages educators to embed activities that facilitate students’ informal learning within the curriculum.
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| 7. |
- Lockett, Nigel, et al.
(författare)
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The Bermuda Triangle in Entrepreneurship Education: The Role of Social Capital in Entrepreneurial Learning
- 2015
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Ingår i: Institute for Small Business and Entrepreneurship; November 11-12, Glasgow, Scotland.
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Konferensbidrag (refereegranskat)abstract
- Objectives. We aim to explore the relationship between the role of social capital and entrepreneurial learning by investigating the entrepreneurial journey of student and graduate entrepreneurs.Prior Work. It is widely acknowledged that the most powerful resource of an entrepreneur is their network: individuals, groups or organisations that support, advice and even finance an entrepreneur’s growth. Because of this, entrepreneurship education programmes have been using entrepreneurs to connect students to the ‘real world’, providing them an initial network of entrepreneurs and the skills to develop their own network. Nonetheless, the real impact of networking on students learning has not yet been fully explored.Approach. This qualitative study uses unstructured interviews with three student and graduate entrepreneurs at both the University of Leeds and Chalmers University of Technology. Interviews focused on understanding the six entrepreneurs’ journey through entrepreneurial activities (critical incidents) and how social networks influenced these activities; interviewees were asked to reflect on their entrepreneurial journey, covering secondary school, university, post-university and expectations for the immediate future.Results. Main findings evidenced that the UK three entrepreneurs started to show some kind of entrepreneurial behaviour during secondary school education. All respondents though increased their network awareness through their entrepreneurial journey: from “don’t know” to “know” to “need”. Moreover, at the beginning the network was mostly informal (family and friends), becoming more formal according to the increased complexity of the entrepreneurial activity. During their entrepreneurial journey, interviewees agreed that at the beginning nobody taught them how to be entrepreneur or even the skills they needed to carry on the entrepreneurial activity. But once their journey became more complex and serious, they needed skills and knowledge that they were not able to develop by their own; in that moment entrepreneurs realised that their network could provide them with people from who learn new capabilities, using informal learning processes to close the gap between their scarcities and needs.Implications. The study exposes that networks facilitate entrepreneurial learning through informal learning processes which need to be translated into entrepreneurship education in a higher education context. One way is to legitimise social networking activities within the university environment, while another is embedding social networking into formal and non-formal entrepreneurship education.Value. Social networking is not simply building a contact list; it is part of the social capital needed to help the entrepreneurial journey. This study exposes the previously missing value of social networking and encourages educators to embed activities within the curriculum that facilitate students’ informal learning.
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| 8. |
- Lockett, Nigel, et al.
(författare)
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The contribution of universities to student and graduate entrepreneurs' social capital: a current fairytale?
- 2016
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Ingår i: Engage HEI Conference, University of Central Lancashire, UK, May 19-20.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper explores how universities contribute to the acquisition of social capital of their student and graduate entrepreneurs. The objective is to identify under what circumstances universities facilitate this in the context of entrepreneurial learning. The study builds on collaboration between three European universities: Chalmers University of Technology, Universidad de Malaga and University of Leeds.Entrepreneurial learning and education literature underpin this study. Stemming from this, the theoretical framework is complemented by research about the impact of social capital on entrepreneurs’ development, and its relevance to the concept of the entrepreneurial university.A qualitative methodological approach involving critical incident technique is used to map student and graduate entrepreneurs’ entrepreneurial journey based on a timeline, specifying stakeholders associated with critical events (entrepreneurial activities of any kind). A visual aid technique was used throughout the interview to assist interviewees in recalling their verbal history. 24 individuals fulfilling criteria: (1) university final year students or first year after graduation; (2) have or were engaged in some entrepreneurial activity; (3) 50% completed some formal entrepreneurship education were interviewed. Nvivo was used to analyse the data through narrative analysis of the social informal learning; i.e. how interviewees learned from others what they needed to learn in order to carry out their entrepreneurial activities. Preliminary analyses of the data identified that entrepreneurship education programmes in these universities engage experienced entrepreneurs to connect students to the ‘real world’, providing them an initial network of role models, as well as skills to develop their own network. It seems that respondents’ entrepreneurial learning follows a pattern. Early stages of the entrepreneurial journey relied on informal learning. As respondents’ entrepreneurial activities expand to include a more complex structure and wider network of stakeholders, they became aware of their need of a more formal learning. To satisfy this need, respondents engaged in non-formal education programmes and, when necessary, they enrolled in formal education programmes. Nevertheless, respondents also used other informal learning sources to cover their self-perceived knowledge gaps. Consequently, this illustrates how interdisciplinarity and entrepreneurship reaches beyond business school learning.Results also suggest that the intertwining of social capital and learning in entrepreneurship occurs before university, from the very first moment that respondents engage in some type of entrepreneurial activity. However, the university is vital in facilitating integrated understanding and developed maturity to manage the complexity of formal, non-formal and informal learning. This comprehensive understanding becomes an essential part of the respondents’ entrepreneurial social capital.This paper contributes by exposing the previously missing value of social networking in entrepreneurship education at universities. At an institutional-level, it legitimises university inclusion of social networking activities into formal and non-formal entrepreneurship education, and encouragement of informal entrepreneurship learning. Moreover, at an individual-level, it motivates educators to embed these activities within the curriculum in order to facilitate entrepreneurial learning. Considering that social networking goes beyond simply building a contact list and that it is part of the social capital necessary for the entrepreneurial journey, this study exposes the previously missing value of social networking in entrepreneurial education programmes. It encourages educators to embed social networking activities into the curriculum to facilitate entrepreneurial learning. The study highlights the importance of social capital acquired at university, as part of student/graduate entrepreneurial journeys. This revitalises the role of the university as a key enabler of economic, social and cultural impact through student/graduate entrepreneurs. Thus, the fairy tale question is answered: universities contribution to student and graduate entrepreneurs’ social capital is no longer a fantasy.Future research needs to be focus on understanding the student/graduate entrepreneurial journey, considering not only entrepreneurial activities as critical incidents, but also other interactions in the entrepreneur’s life. Moreover, the inclusion of other countries and universities to identify a clearer pattern of how universities contribute to acquisition of social capital of their student and graduate entrepreneurs.
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| 9. |
- Lockett, Nigel, et al.
(författare)
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The university is dead; long live the university: Are universities the principle source of social capital for student and graduate entrepreneurs?
- 2016
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Ingår i: ECSB Entrepreneurship Education (3E) Conference, May 11-13, Leeds UK. ; , s. 1-15
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Konferensbidrag (refereegranskat)abstract
- This paper explores the role of social capital acquired by students during student and graduate entrepreneurial journeys at university. The objective is to understand how universities can facilitate social capital acquisition in the context of entrepreneurial learning. The study builds on a collaboration between three European universities: Chalmers University of Technology (Sweden), University of Leeds (United Kingdom), and Universidad de Malaga (Spain).We ask:1.What is the relationship between social capital and entrepreneurial learning? What is the added value as perceived by student and graduate entrepreneurs?2.How can educators use the development of social capital to enhance entrepreneurial learning, particularly across formal, non-formal and informal entrepreneurial learning activities?3.What are implications for the future of universities as centres of knowledge, creativity and learning?The study is underpinned by relevant literature regarding entrepreneurial learning and education. It also addresses the impact of social capital on the development of entrepreneurs, and the research regarding the entrepreneurial university.The study utilises a qualitative methodological approach, drawing on what is termed the critical incident technique. To start, student/graduate entrepreneurs were asked to map their entrepreneurial journey based on a timeline, specifying stakeholders whom they associated to critical events. This visual aid was then used throughout the interview, in which respondents provided a verbal history about their timeline and the critical relationships which had influenced their own entrepreneurial behaviour.We selected 24 respondents based on three criteria: (1) they had to be a university final year student or in their first year of graduation (both undergraduate and postgraduate students from various subjects were selected); (2) they had to have been engaged in some entrepreneurial activity; (3) the sample was split 50:50 between individuals having completed some formal entrepreneurship education (credit-bearing courses) and individuals without any formal entrepreneurship education. Gender and country variables were also considered. Data was analysed using narrative analysis of the individual learning, and social network analysis of the socialised learning (to address network and social capital developments). Building on social learning theory, socialised learning is understood to include observation and emulation of role models -role-sets- as part of an individual’s identity and legitimacy development.Preliminary analyses of the data inform us that mentors known in informal and non-formal education events and incubators are the main source to ask for help when respondents feel they need to. Maybe because the interview is retroactive, respondents were aware of this need before it was too late; in fact, respondents were the ones who deliberately contact these people to ask them for help in their various entrepreneurial activities. This paper contributes to knowledge and understanding by exposing a previously understudied value of social networking in entrepreneurship education at universities. At an institutional-level, it legitimizes university inclusion of social networking activities into formal and non-formal entrepreneurship education, and the encouragement of informal entrepreneurial learning. Moreover, at an individual-level, it motivates educators to embed these activities within the curriculum in order to facilitate entrepreneurial learning. Nonetheless, to more fully understand the student/graduate entrepreneurial journey, more research is needed. Future work should not only consider entrepreneurial activities as critical incidents, but also the relevance of other interactions in the entrepreneur’s life, leading to a greater understanding of their economic, social and cultural impact.Social networking goes beyond simply building a contact list; it is part of the social capital necessary for the entrepreneurial journey. This study exposes a previously missing value of social networking in entrepreneurial education programmes. It encourages educators to embed social networking activities into the curriculum to facilitate entrepreneurial learning. The study highlights the importance of social capital acquired at university, as part of the student/graduate entrepreneurial journeys. This revitalises the role of the university as a key enabler of economic, social and cultural impact through student/graduate entrepreneurs. Thus, the university is dead (as was traditionally understood); long live the (entrepreneurial) university.
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| 10. |
- Malhi, Yadvinder, et al.
(författare)
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The linkages between photosynthesis, productivity, growth and biomass in lowland Amazonian forests
- 2015
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Ingår i: Global Change Biology. - : Wiley. - 1354-1013. ; 21:6, s. 2283-2295
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Tidskriftsartikel (refereegranskat)abstract
- Understanding the relationship between photosynthesis, net primary productivity and growth in forest ecosystems is key to understanding how these ecosystems will respond to global anthropogenic change, yet the linkages among these components are rarely explored in detail. We provide the first comprehensive description of the productivity, respiration and carbon allocation of contrasting lowland Amazonian forests spanning gradients in seasonal water deficit and soil fertility. Using the largest data set assembled to date, ten sites in three countries all studied with a standardized methodology, we find that (i) gross primary productivity (GPP) has a simple relationship with seasonal water deficit, but that (ii) site-to-site variations in GPP have little power in explaining site-to-site spatial variations in net primary productivity (NPP) or growth because of concomitant changes in carbon use efficiency (CUE), and conversely, the woody growth rate of a tropical forest is a very poor proxy for its productivity. Moreover, (iii) spatial patterns of biomass are much more driven by patterns of residence times (i.e. tree mortality rates) than by spatial variation in productivity or tree growth. Current theory and models of tropical forest carbon cycling under projected scenarios of global atmospheric change can benefit from advancing beyond a focus on GPP. By improving our understanding of poorly understood processes such as CUE, NPP allocation and biomass turnover times, we can provide more complete and mechanistic approaches to linking climate and tropical forest carbon cycling.
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