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1.	Braisch, U, et al. (author) Identification of symbol digit modality test score extremes in Huntington's disease 2019 In: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. - : Wiley. - 1552-485X .- 1552-4841. ; 180:3, s. 232-245 Journal article (peer-reviewed)
2.	Orth, M, et al. (author) Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY 2011 In: Journal of neurology, neurosurgery, and psychiatry. - : BMJ. - 1468-330X .- 0022-3050. ; 82:12, s. 1409- Journal article (other academic/artistic)
3.	Kieburtz, K, et al. (author) A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease 2013 In: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 70:1, s. 25-33 Journal article (peer-reviewed)
4.	Bohlen, S, et al. (author) Physical therapy in Huntington's disease : towards objective assessments? 2013 In: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 20:2, s. 389-393 Journal article (peer-reviewed)abstract Background and purposePhysical therapy is recommended for the treatment of Huntington's disease, but reliable studies investigating its efficacy are almost non-existent. This may in part be due to the lack of suitable outcome measures. Therefore, we investigated the applicability of novel quantitative and objective assessments of motor dysfunction in the evaluation of physical therapy interventions aimed at improving gait and posture.MethodsTwelve patients with Huntington disease received a predefined twice-weekly intervention focusing on posture and gait over 6 weeks. The GAITRite mat and a force plate were used for objective and quantitative assessments. The Unified Huntingtons Disease Rating Scale Total Motor Score, the timed Up &Go test, and the Berg Balance Scale were used as clinical outcome measures.ResultsSignificant improvements were seen in GAITRite measures after therapy. Improvements were also seen in the Up & Go test and Berg Balance Scale, whereas force plate measures and Total Motor Scores did not change.ConclusionsThe results suggest that physical therapy has a positive effect on gait in Huntington's disease. The study shows that objective and quantitative measures of gait and posture may serve as endpoints in trials assessing the efficacy of physical therapy. They should be explored further in larger trials applying a randomized controlled setting.
5.	de Yebenes, JG, et al. (author) Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial 2011 In: The Lancet. Neurology. - 1474-4465. ; 10:12, s. 1049-1057 Journal article (peer-reviewed)

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Type of publication: journal article (5)

Type of content: peer-reviewed (4); other academic/artistic (1)

Author/Editor: Reilmann, R (5); Bohlen, S (4); Saft, C (4); Schmidt, S. (3); Barker, RA (3); Hoffmann, R. (3); show more...; Wright, J (3); Wojcik, M. (3); Patel, A (3); Paucar, M (3); Trautmann, S. (3); Squitieri, F (3); Craufurd, D (3); Novak, M (3); Priller, J (3); Romero, I (3); Raymond, L (3); Landwehrmeyer, B (3); Andrews, T. (3); de Souza, J (3); Nielsen, JE (3); Bos, R. (3); Landwehrmeyer, GB (3); Orth, M (3); Burgunder, JM (3); Roos, RAC (3); Witkowski, G (3); Zielonka, D (3); Nowak, M (3); Gelderblom, H (3); Storch, A (3); Wolz, A (3); Wolz, M (3); Boelmans, K (3); Munchau, A (3); Schmalfeld, J (3); Zittel, S (3); Sass, C (3); Cormio, C (3); de Tommaso, M (3); Sciruicchio, V (3); Serpino, C (3); van den Bogaard, SJA (3); Soltan, W (3); Rudzinska, M (3); Banaszkiewicz, K (3); Ciesielska, A (3); Sempolowicz, J (3); Antczak, J (3); Jachinska, K (3); show less...

University: Karolinska Institutet (4); Uppsala University (2); Marie Cederschiöld högskola (1)

Language: English (5)

Research subject (UKÄ/SCB): Medical and Health Sciences (4)

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