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- Markiewicz-Kijewska, M, et al.
(författare)
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ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network
- 2021
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Ingår i: Children (Basel, Switzerland). - : MDPI AG. - 2227-9067. ; 8:9
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Tidskriftsartikel (refereegranskat)abstract
- An increasing number of AB0-incompatible (AB0i) liver transplantations (LT) are being undertaken internationally in recent years due to organ shortages and the need for urgent transplantation. The aim of our study was establish the value of ABOi LT from available retrospective results of AB0i pediatric liver transplantations performed in European reference centers now belonging to the TransplantChild, European Reference Network (ERN). Data from medical records were analyzed, including demographic data, diagnosis, urgency of transplantation, time on the waiting list, PELD/MELD score, desensitization procedures, immunosuppression, selected post-transplant complications, and patient and graft survival. A total of 142 patients (pts) with transplants between 1986 and 2018 in 8 European transplant centers were included in the study. The indications for liver transplantation were: cholestatic diseases in 62 pts, acute liver failure in 42 pts, and other conditions in the remaining 38 pts. Sixty-six patients received grafts from living donors, and seventy-six received grafts from deceased donors. Both patient and graft survival were significantly affected by deceased donor type, urgent transplantation, and the development of vascular complications. In the multivariate analysis, vascular complications had a negative impact on patient and graft survival, while a longer time from the first AB0i LT in the study showed better results, suggesting an international learning experience. In conclusion, we believe that AB0i LT in children is now a safe procedure that may be adopted more readily in children.
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- Mansurbeg, Howri, et al.
(författare)
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Diagenetic evolution and porosity destruction of turbiditic hybrid arenites and siliciclastic sandstones of foreland basins: Evidence from the Eocene Hecho Group, Pyrenees, Spain
- 2009
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Ingår i: Journal of Sedimentary Research. - : Society for Sedimentary Geology. - 1527-1404 .- 1938-3681. ; 79:9-10, s. 711-735
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Tidskriftsartikel (refereegranskat)abstract
- This study aims to unravel the impact of diagenetic alterations on porosity loss of foreland-basin turbiditic hybrid arenites and associated siliciclastic sandstones of the Eocene Hecho Group (south-central Pyrenees, Spain). In this succession, hybrid arenites and calclithites are extensively cemented by mesogenetic calcite cement (delta O-18(VPDB) = -10.0 parts per thousand to -5.8 parts per thousand; T-h, mode = 80 degrees C salinity mode = 18.8 wt% eq. NaCl), Fe-dolomite (delta(18)(OVPDB) = -8.5 parts per thousand to -6.3 parts per thousand) and trace amounts of siderite. The extent of carbonate cementation is interpreted to be related to the amounts of extrabasinal and intrabasinal carbonate grains, which provided nuclei and sources for the precipitation and growth of carbonate cements. Other diagenetic alterations, such as pyrite and albitization, had no impact on reservoir quality. Scarce early diagenetic cements, coupled with abundant ductile carbonate and siliciclastic framework grains, have led to rapid porosity loss owing to compaction. Conversely, abundant quartz in the sandstones prevented rapid loss of porosity by mechanical compaction. Reservoir quality was affected by mesogenetic cementation by quartz overgrowths, calcite and dolomite intergranular pressure dissolution of quartz grains, and formation of fracture-filling calcite cement (delta O-18(V-PDB) values from -10.4 parts per thousand to -7.8 parts per thousand; T-h temperatures of approximate to 150 degrees C), which are attributed to deep circulation of hot meteoric waters during extensional stages of tectonism. The results of this study illustrate that diagenetic evolution pathways of the arenites and sandstones are closely linked to the variation in detrital composition, particularly the proportion and types of extrabasinal noncarbonates, extrabasinal carbonates, and intrabasinal carbonate grains. These insights suggest that marine turbiditic hybrid arenites and calclithites of foreland basins are subjected to more rapid and extensive porosity loss owing to compaction and cementation than associated siliciclastic sandstones. Degradation of reservoir quality makes these hybrid arenites, calclithites, and sandstones suitable as tight gas reservoirs, but only if fracture porosity and permeability develop during tectonic deformation.
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