| 1. |
- Chatterjee, Samir, et al.
(författare)
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Information Systems Research: Making an Impact in a Publish-or-Perish World
- 2018
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Ingår i: Communications of the Association for Information Systems. - : Association for Information Systems. - 1529-3181. ; 43:1, s. 466-481
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Tidskriftsartikel (refereegranskat)abstract
- This paper reports on the panel discussion that took place at the European Conference on Information Systems (ECIS) in Guimarães, Portugal, on 9 June, 2017. The discussion focused on three central questions: 1) “What does research impact mean for you?”, 2) “What is your approach to making an impact with your research?”, and 3) “What advice would you give to PhD students and early-career scholars?”. While the five panelists (Samir Chatterjee, Alan R. Dennis, Shirley Gregor, Magnus Mähring, and Peter Mertens) partly differed in their views on what impactful research is and how to conduct it, they seemed to largely agree that assessing impact requires a multidimensional view, that impactful IS research requires a clear link to real-world problems (“grand challenges”), and that young scholars need to avoid the trap of confusing research gaps with research relevance. With the panel discussion and this report, we hope to initiate a discussion on the essential topic of research impact in the IS discipline and to contribute to the development of a more uniform, yet more diverse, understanding and appreciation of different approaches to making an impact with IS research.
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| 2. |
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Control modes versus control styles: Investigating isd project control effects at the individual level
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Proceedings (redaktörskap) (refereegranskat)abstract
- Most previous research on ISD project control conceptualizes control activities in terms of control modes and focuses on performance effects at the project level. This seems to oversimplify the way controls 'work' by neglecting the multidimensionality of control activities and their effects at the individual level. In this paper, we adopt an expanded view of ISD project control, employing data from 92 ISD projects to analyze how different control modes (what?) and control styles (how?) relate to controllee task performance and job satisfaction. Importantly, our results suggest that control style is more important than control modes in explaining individual-level control effects. Moreover, as hypothesized, formal and informal controls positively affect task performance, while only informal controls have a positive effect on job satisfaction. Finally, we find significant interaction effects between control style and formal controls, suggesting a complex non-linear relationship between the two, which opens interesting avenues for future research.
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| 3. |
- Gioti, Anastasia, et al.
(författare)
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Genomic Insights into the Atopic Eczema-Associated Skin Commensal Yeast Malassezia sympodialis
- 2013
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Ingår i: mBio. - 2161-2129 .- 2150-7511. ; 4:1, s. e00572-12-
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Tidskriftsartikel (refereegranskat)abstract
- Malassezia commensal yeasts are associated with a number of skin disorders, such as atopic eczema/dermatitis and dandruff, and they also can cause systemic infections. Here we describe the 7.67-Mbp genome of Malassezia sympodialis, a species associated with atopic eczema, and contrast its genome repertoire with that of Malassezia globosa, associated with dandruff, as well as those of other closely related fungi. Ninety percent of the predicted M. sympodialis protein coding genes were experimentally verified by mass spectrometry at the protein level. We identified a relatively limited number of genes related to lipid biosynthesis, and both species lack the fatty acid synthase gene, in line with the known requirement of these yeasts to assimilate lipids from the host. Malassezia species do not appear to have many cell wall-localized glycosylphosphatidylinositol (GPI) proteins and lack other cell wall proteins previously identified in other fungi. This is surprising given that in other fungi these proteins have been shown to mediate interactions (e. g., adhesion and biofilm formation) with the host. The genome revealed a complex evolutionary history for an allergen of unknown function, Mala s 7, shown to be encoded by a member of an amplified gene family of secreted proteins. Based on genetic and biochemical studies with the basidiomycete human fungal pathogen Cryptococcus neoformans, we characterized the allergen Mala s 6 as the cytoplasmic cyclophilin A. We further present evidence that M. sympodialis may have the capacity to undergo sexual reproduction and present a model for a pseudobipolar mating system that allows limited recombination between two linked MAT loci. IMPORTANCE Malassezia commensal yeasts are associated with a number of skin disorders. The previously published genome of M. globosa provided some of the first insights into Malassezia biology and its involvement in dandruff. Here, we present the genome of M. sympodialis, frequently isolated from patients with atopic eczema and healthy individuals. We combined comparative genomics with sequencing and functional characterization of specific genes in a population of clinical isolates and in closely related model systems. Our analyses provide insights into the evolution of allergens related to atopic eczema and the evolutionary trajectory of the machinery for sexual reproduction and meiosis. We hypothesize that M. sympodialis may undergo sexual reproduction, which has important implications for the understanding of the life cycle and virulence potential of this medically important yeast. Our findings provide a foundation for the development of genetic and genomic tools to elucidate host-microbe interactions that occur on the skin and to identify potential therapeutic targets.
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| 4. |
- Mähring, Magnus, et al.
(författare)
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Control configuration and control enactment in information systems projects: Review and expanded theoretical framework
- 2016
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Ingår i: MIS Quarterly. - : University of Minnesota, Management Information Systems Research Center. - 0276-7783. ; 40:3, s. 741-774
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Tidskriftsartikel (refereegranskat)abstract
- The control of information systems (IS) projects is a key activity for deployment of information technology (IT) resources and ultimately for value creation through IT. For the last 20 years, research on IS project control has grown to cover a wide range of aspects and issues, including control modes, amounts, and portfolios, control in internal and outsourced settings, and control antecedents, consequences, and dynamics. There is an important theoretical and practical impetus for this research, since the nature of IS projects creates specific and challenging conditions for control, and since control research in neighboring disciplines often neglects temporary endeavors such as projects. In this study, we provide a systematic review and synthesis of the literature and develop an expanded theoretical framework for IS project control with supporting conjectures. Our review reveals that existing research primarily studies the contextual antecedents and performance consequences of control modes and amounts, and thus focuses on control portfolio configurations (what). In contrast, prior research largely neglects control enactment, that is, how the controller interacts with the controllee to put the portfolio of controls into practice. Our expanded framework points to the importance of studying control portfolio configurations and control enactment (in terms of control style and control congruence) in combination, in order to better understand IS project control effectiveness. Expanding the toolbox of concepts available to IS researchers, our framework helps resolve existing research gaps and inconsistencies, and opens up new avenues for future research on the control of IS projects.
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| 5. |
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| 6. |
- ODonnell, Michael, et al.
(författare)
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Registered Replication Report: Dijksterhuis and van Knippenberg (1998)
- 2018
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Ingår i: Perspectives on Psychological Science. - : SAGE PUBLICATIONS LTD. - 1745-6916 .- 1745-6924. ; 13:2, s. 268-294
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Tidskriftsartikel (refereegranskat)abstract
- Dijksterhuis and van Knippenberg (1998) reported that participants primed with a category associated with intelligence (professor) subsequently performed 13% better on a trivia test than participants primed with a category associated with a lack of intelligence (soccer hooligans). In two unpublished replications of this study designed to verify the appropriate testing procedures, Dijksterhuis, van Knippenberg, and Holland observed a smaller difference between conditions (2%-3%) as well as a gender difference: Men showed the effect (9.3% and 7.6%), but women did not (0.3% and -0.3%). The procedure used in those replications served as the basis for this multilab Registered Replication Report. A total of 40 laboratories collected data for this project, and 23 of these laboratories met all inclusion criteria. Here we report the meta-analytic results for those 23 direct replications (total N = 4,493), which tested whether performance on a 30-item general-knowledge trivia task differed between these two priming conditions (results of supplementary analyses of the data from all 40 labs, N = 6,454, are also reported). We observed no overall difference in trivia performance between participants primed with the professor category and those primed with the hooligan category (0.14%) and no moderation by gender.
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| 7. |
- Palmer, Elizabeth E., et al.
(författare)
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Functional and clinical studies reveal pathophysiological complexity of CLCN4-related neurodevelopmental condition
- 2023
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Ingår i: Molecular Psychiatry. - : SPRINGERNATURE. - 1359-4184 .- 1476-5578. ; 28:2, s. 668-697
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Tidskriftsartikel (refereegranskat)abstract
- Missense and truncating variants in the X-chromosome-linked CLCN4 gene, resulting in reduced or complete loss-of-function (LOF) of the encoded chloride/proton exchanger ClC-4, were recently demonstrated to cause a neurocognitive phenotype in both males and females. Through international clinical matchmaking and interrogation of public variant databases we assembled a database of 90 rare CLCN4 missense variants in 90 families: 41 unique and 18 recurrent variants in 49 families. For 43 families, including 22 males and 33 females, we collated detailed clinical and segregation data. To confirm causality of variants and to obtain insight into disease mechanisms, we investigated the effect on electrophysiological properties of 59 of the variants in Xenopus oocytes using extended voltage and pH ranges. Detailed analyses revealed new pathophysiological mechanisms: 25% (15/59) of variants demonstrated LOF, characterized by a "shift" of the voltage-dependent activation to more positive voltages, and nine variants resulted in a toxic gain-of-function, associated with a disrupted gate allowing inward transport at negative voltages. Functional results were not always in line with in silico pathogenicity scores, highlighting the complexity of pathogenicity assessment for accurate genetic counselling. The complex neurocognitive and psychiatric manifestations of this condition, and hitherto under-recognized impacts on growth, gastrointestinal function, and motor control are discussed. Including published cases, we summarize features in 122 individuals from 67 families with CLCN4-related neurodevelopmental condition and suggest future research directions with the aim of improving the integrated care for individuals with this diagnosis.
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| 8. |
- Remus, Ulrich, et al.
(författare)
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Control Modes Versus Control Styles: Investigating ISD Project Control Effects at the Individual Level
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Most previous research on ISD project control conceptualizes control activities in terms of control modes and focuses on performance effects at the project level. This seems to oversimplify the way controls ‘work’ by neglecting the multidimensionality of control activities and their effects at the individual level. In this paper, we adopt an expanded view of ISD project control, employing data from 92 ISD projects to analyze how different control modes (what?) and control styles (how?) relate to controllee task performance and job satisfaction. Importantly, our results suggest that control style is more important than control modes in explaining individual-level control effects. Moreover, as hypothesized, formal and informal controls positively affect task performance, while only informal controls have a positive effect on job satisfaction. Finally, we find significant interaction effects between control style and formal controls, suggesting a complex non-linear relationship between the two, which opens interesting avenues for future research.
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| 9. |
- Remus, Ulrich, et al.
(författare)
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Why do you control? The concept of control purpose and its implications for is project control research
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Existing IS project control research primarily draws on agency theory to conceptualize control, relating control closely to aligning behaviors of self-interested controllees with organizational objectives. Recent studies in neighboring disciplines, however, suggest that the agency view of control is too narrow to fully understand control activities. Informed by these studies as well as drawing on stewardship and coordination theory, we introduce the concept of control purpose to the IS literature. We define this concept as the intentions underlying the controller's control activities, and distinguish between appropriation-And coordination-oriented controls. To evaluate the control purpose concept, we conduct a secondary analysis of 21 IS project control case studies. Results show that, despite their stated agency focus, most studies report on controls addressing both appropriation concerns and coordination requirements. On this basis, we discuss two potential research areas, knowledge management and control dynamics, where the control purpose concept can offer novel insights.
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