| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 2. |
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| 3. |
- Winkler, TW, et al.
(författare)
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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
- 2022
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1, s. 580-
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Tidskriftsartikel (refereegranskat)abstract
- Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
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| 4. |
- Teumer, A, et al.
(författare)
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Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4130-
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Tidskriftsartikel (refereegranskat)abstract
- Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.
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| 5. |
- Van de Walle, J., et al.
(författare)
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Coulomb excitation of neutron-rich Zn isotopes: First observation of the 2(1)(+) state in Zn-80
- 2007
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Ingår i: Physical Review Letters. - 1079-7114. ; 99:14
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Tidskriftsartikel (refereegranskat)abstract
- Neutron-rich, radioactive Zn isotopes were investigated at the Radioactive Ion Beam facility REX-ISOLDE (CERN) using low-energy Coulomb excitation. The energy of the 2(1)(+) state in Zn-78 could be firmly established and for the first time the 2(+)-> 0(1)(+) transition in Zn-80 was observed at 1492(1) keV. B(E2,2(1)(+)-> 0(1)(+)) values were extracted for Zn-74,Zn-76,Zn-78,Zn-80 and compared to large scale shell model calculations. With only two protons outside the Z=28 proton core, Zn-80 is the lightest N=50 isotone for which spectroscopic information has been obtained to date. Two sets of advanced shell model calculations reproduce the observed B(E2) systematics. The results for N=50 isotones indicate a good N=50 shell closure and a strong Z=28 proton core polarization. The new results serve as benchmarks to establish theoretical models, predicting the nuclear properties of the doubly magic nucleus Ni-78.
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| 6. |
- de Walle, J. V., et al.
(författare)
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Coulomb excitation of the N=50 nucleus Zn-80
- 2008
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Ingår i: AIP Conference Proceedings. - 1551-7616 .- 0094-243X. ; 1012, s. 291-295 453
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Konferensbidrag (refereegranskat)abstract
- Neutron rich Zinc isotopes, including the N=50 nucleus Zn-80, were produced and post-accelerated at the Radioactive Ion Beam (RIB) facility REX-ISOLDE (CERN). Low-energy Coulomb excitation was induced on these isotopes after post-acceleration, yielding B(E2) strengths to the first excited 2(+) states. For the first time, an excited state in Zn-80 was observed and the 2(1)(+) state in Zn-78 was established. The measured B(E2,2(1)(+) -> 0(1)(+)) values are compared to two sets of large scale shell model calculations. Both calculations reproduce the observed B(E2) systematics for the full Zinc isotopic chain. The results for N=50 isotones indicate a good N=50 shell closure and a strong Z=28 proton core polarization. The new results serve as benchmarks to establish theoretical models, predicting the nuclear properties of the doubly magic nucleus Ni-78.
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| 7. |
- Hurst, A. M., et al.
(författare)
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Measurement of the sign of the spectroscopic quadrupole moment for the 2(1)(+) state in Se-70: No evidence for oblate shape
- 2007
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Ingår i: Physical Review Letters. - 1079-7114. ; 98:7
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Tidskriftsartikel (refereegranskat)abstract
- Using a method whereby molecular and atomic ions are independently selected, an isobarically pure beam of Se-70 ions was postaccelerated to an energy of 206 MeV using REX-ISOLDE. Coulomb-excitation yields for states in the beam and target nuclei were deduced by recording deexcitation gamma rays in the highly segmented MINIBALL gamma-ray spectrometer in coincidence with scattered particles in a silicon detector. At these energies, the Coulomb-excitation yield for the first 2(+) state is expected to be strongly sensitive to the sign of the spectroscopic quadrupole moment through the nuclear reorientation effect. Experimental evidence is presented here for a prolate shape for the first 2(+) state in Se-70, reopening the question over whether there are, as reported earlier, deformed oblate shapes near to the ground state in the light selenium isotopes.
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| 8. |
- Ilieva, S., et al.
(författare)
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Coulomb excitation of neutron-rich Cd isotopes
- 2014
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 89:1
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Tidskriftsartikel (refereegranskat)abstract
- The isotopes (122),(124),Cd-126 were studied in a "safe" Coulomb-excitation experiment at the radioactive ion-beam facility REX-ISOLDE at CERN. The reduced transition probabilities B(E2; 0(g. s)(vertical bar) -> 2(1)(+)) and limits for the quadrupole moments of the first 2(+) excited states in the three isotopes were determined. The onset of collectivity in the vicinity of the Z = 50 and N = 82 shell closures is discussed by comparison with shell model and beyond mean-field calculations.
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| 9. |
- Kröll, Th, et al.
(författare)
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Quadrupole Collectivity of neutron-rich nuclei around 132Sn
- 2008
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Ingår i: Frontiers in Nuclear Structure, Astrophysics, and Reactions, FINUSTAR 2007. - : AIP. - 9780735405325 ; 1012, s. 296-299
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Konferensbidrag (refereegranskat)abstract
- We report on the "safe" Coulomb excitation of neutron-rich Cd, Xe, and Ba isotopes in the vicinity of the doubly-magic nucleus 132Sn. The radioactive nuclei have been produced by ISOLDE at CERN and postaccelerated by the REX-ISOLDE facility. The γ-decay of excited states has been detected by the MINIBALL array. The presented preliminary results for the B(E2) values are consistent with expectations from phenomenological systematics and will be compared with theoretical calculations.
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| 10. |
- Van de Walle, J., et al.
(författare)
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Low-energy Coulomb excitation of neutron-rich zinc isotopes
- 2009
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 79:1
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Tidskriftsartikel (refereegranskat)abstract
- At the radioactive ion beam facility REX-ISOLDE, neutron-rich zinc isotopes were investigated using low-energy Coulomb excitation. These experiments have resulted in B(E2, 2(1)(+)-> 0(1)(+)) values in Zn74-80, B(E2, 4(1)(+)-> 2(1)(+)) values in Zn-74,Zn-76 and the determination of the energy of the first excited 2(1)(+) states in Zn-78,Zn-80. The zinc isotopes were produced by high-energy proton- (A = 74, 76, 80) and neutron-(A = 78) induced fission of U-238, combined with selective laser ionization and mass separation. The isobaric beam was postaccelerated by the REX linear accelerator and Coulomb excitation was induced on a thin secondary target, which was surrounded by the MINIBALL germanium detector array. In this work, it is shown how the selective laser ionization can be used to deal with the considerable isobaric beam contamination and how a reliable normalization of the experiment can be achieved. The results for zinc isotopes and the N = 50 isotones are compared to collective model predictions and state-of-the-art large-scale shell-model calculations, including a recent empirical residual interaction constructed to describe the present experimental data up to 2004 in this region of the nuclear chart.
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