| 1. |
- Asim, Muhammad Nabeel, et al.
(författare)
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L2S-MirLoc : A Lightweight Two Stage MiRNA Sub-Cellular Localization Prediction Framework
- 2021
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Ingår i: Proceedings of the International Joint Conference on Neural Networks. - : IEEE. - 9780738133669 - 9781665439008 - 9781665445979
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Konferensbidrag (refereegranskat)abstract
- A comprehensive understanding of miRNA sub-cellular localization may leads towards better understanding of physiological processes and support the fixation of diverse irregularities present in a variety of organisms. To date, diverse computational methodologies have been proposed to automatically infer sub-cellular localization of miR-NAs solely using sequence information, however, existing approaches lack in performance. Considering the success of data transformation approaches in Natural Language Processing which primarily transform multi-label classification problem into multi-class classification problem, here, we introduce three different data transformation approaches namely binary relevance, label power set, and classifier chains. Using data transformation approaches, at 1st stage, multi-label miRNA sub-cellular localization problem is transformed into multi-class problem. Then, at 2nd stage, 3 different machine learning classifiers are used to estimate which classifier performs better with what data transformation approach for hand on task. Empirical evaluation on independent test set indicates that L2S-MirLoc selected combination based on binary relevance and deep random forest outperforms state-of-the-art performance values by significant margin.
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| 2. |
- Earley, Eric, 1989, et al.
(författare)
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Cutting Edge Bionics in Highly Impaired Individuals: A Case of Challenges and Opportunities
- 2024
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Ingår i: IEEE Transactions on Neural Systems and Rehabilitation Engineering. - 1558-0210 .- 1534-4320. ; 32, s. 1013-1022
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Tidskriftsartikel (refereegranskat)abstract
- Highly impaired individuals stand to benefit greatly from cutting-edge bionic technology, however concurrent functional deficits may complicate the adaptation of such technology. Here, we present a case in which a visually impaired individual with bilateral burn injury amputation was provided with a novel transradial neuromusculoskeletal prosthesis comprising skeletal attachment via osseointegration and implanted electrodes in nerves and muscles for control and sensory feedback. Difficulties maintaining implant hygiene and donning and doffing the prosthesis arose due to his contralateral amputation, ipsilateral eye loss, and contralateral impaired vision necessitating continuous adaptations to the electromechanical interface. Despite these setbacks, the participant still demonstrated improvements in functional outcomes and the ability to control the prosthesis in various limb positions using the implanted electrodes. Our results demonstrate the importance of a multidisciplinary, iterative, and patient-centered approach to making cutting-edge technology accessible to patients with high levels of impairment.
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