SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Stuart D. I.) "

Sökning: WFRF:(Stuart D. I.)

  • Resultat 1-10 av 82
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Aad, G, et al. (författare)
  • 2015
  • swepub:Mat__t
  •  
2.
  • Niemi, MEK, et al. (författare)
  • 2021
  • swepub:Mat__t
  •  
3.
  • Kanai, M, et al. (författare)
  • 2023
  • swepub:Mat__t
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  • Campbell, PJ, et al. (författare)
  • Pan-cancer analysis of whole genomes
  • 2020
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
  • Tidskriftsartikel (refereegranskat)abstract
    • Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
  •  
8.
  •  
9.
  •  
10.
  • Dornelas, M., et al. (författare)
  • BioTIME: A database of biodiversity time series for the Anthropocene
  • 2018
  • Ingår i: Global Ecology and Biogeography. - : Wiley. - 1466-822X .- 1466-8238. ; 27:7, s. 760-786
  • Tidskriftsartikel (refereegranskat)abstract
    • Motivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene. Main types of variables included: The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record. Spatial location and grain: BioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km(2) (158 cm(2)) to 100 km(2) (1,000,000,000,000 cm(2)). Time period and grainBio: TIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year. Major taxa and level of measurement: BioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 82
Typ av publikation
tidskriftsartikel (74)
forskningsöversikt (4)
konferensbidrag (1)
Typ av innehåll
refereegranskat (77)
övrigt vetenskapligt/konstnärligt (2)
Författare/redaktör
Johnson, R (9)
Kumar, S (8)
Stefansson, Kari (8)
Li, Y. (7)
King, D. (7)
Chasman, Daniel I. (7)
visa fler...
van Duijn, Cornelia ... (7)
Thorsteinsdottir, Un ... (7)
Rotter, Jerome I. (7)
Walker, R. (6)
Yang, Y. (6)
Kim, Y. (6)
Kim, J. (6)
Patel, A (6)
Ridker, Paul M. (6)
Martin, Nicholas G. (6)
Brunak, S. (6)
Chen, K. (5)
Nowak, S. (5)
Price, D. (5)
Wu, Y. (5)
Yu, J. (5)
Zhang, J. (5)
Marshall, R. (5)
Clark, M. (5)
Garcia, J. (5)
Lee, S (5)
Lewis, J (5)
Sander, C. (5)
Thomas, J. (5)
Ohara, M (5)
Hobirk, J (5)
Kappatou, A (5)
Kirov, K (5)
Lennholm, M (5)
Lerche, E (5)
Menmuir, S (5)
Valisa, M (5)
Maslov, M. (5)
Miyano, S (5)
Smith, J. (5)
Price, C (5)
Freedman, Barry I. (5)
Bishop, D Timothy (5)
Jones, C (5)
Amin, Najaf (5)
Thorleifsson, Gudmar (5)
Torrents, D (5)
Schreiber, S (5)
Oostra, Ben A. (5)
visa färre...
Lärosäte
Karolinska Institutet (40)
Uppsala universitet (29)
Lunds universitet (22)
Göteborgs universitet (14)
Umeå universitet (13)
Stockholms universitet (7)
visa fler...
Linköpings universitet (7)
Kungliga Tekniska Högskolan (5)
Chalmers tekniska högskola (5)
Sveriges Lantbruksuniversitet (3)
Karlstads universitet (2)
Högskolan Dalarna (2)
Luleå tekniska universitet (1)
Mittuniversitetet (1)
Linnéuniversitetet (1)
visa färre...
Språk
Engelska (82)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (39)
Naturvetenskap (20)
Teknik (3)
Lantbruksvetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy