SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Stuart K) "

Sökning: WFRF:(Stuart K)

  • Resultat 1-10 av 231
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Kanai, M, et al. (författare)
  • 2023
  • swepub:Mat__t
  •  
2.
  • Niemi, MEK, et al. (författare)
  • 2021
  • swepub:Mat__t
  •  
3.
  • Aad, G, et al. (författare)
  • 2015
  • swepub:Mat__t
  •  
4.
  •  
5.
  • Campbell, PJ, et al. (författare)
  • Pan-cancer analysis of whole genomes
  • 2020
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
  • Tidskriftsartikel (refereegranskat)abstract
    • Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  • Thoma, B, et al. (författare)
  • An international, interprofessional investigation of the self-reported podcast listening habits of emergency clinicians: A METRIQ Study
  • 2020
  • Ingår i: CJEM. - : Springer Science and Business Media LLC. - 1481-8043 .- 1481-8035. ; 22:1, s. 112-117
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectivesPodcasts are increasingly being used for medical education. A deeper understanding of usage patterns would inform both producers and researchers of medical podcasts. We aimed to determine how and why podcasts are used by emergency medicine and critical care clinicians.MethodsAn international interprofessional sample (medical students, residents, physicians, nurses, physician assistants, and paramedics) was recruited through direct contact and a multimodal social media (Twitter and Facebook) campaign. Each participant completed a survey outlining how and why they utilize medical podcasts. Recruitment materials included an infographic and study website.Results390 participants from 33 countries and 4 professions (medicine, nursing, paramedicine, physician assistant) completed the survey. Participants most frequently listened to medical podcasts to review new literature (75.8%), learn core material (75.1%), and refresh memory (71.8%). The majority (62.6%) were aware of the ability to listen at increased speeds, but most (76.9%) listened at 1.0 x (normal) speed. All but 25 (6.4%) participants concurrently performed other tasks while listening. Driving (72.3%), exercising (39.7%), and completing chores (39.2%) were the most common. A minority of participants used active learning techniques such as pausing, rewinding, and replaying segments of the podcast. Very few listened to podcasts multiple times.ConclusionsAn international cohort of emergency clinicians use medical podcasts predominantly for learning. Their listening habits (rarely employing active learning strategies and frequently performing concurrent tasks) may not support this goal. Further exploration of the impact of these activities on learning from podcasts is warranted.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 231
Typ av publikation
tidskriftsartikel (201)
forskningsöversikt (14)
konferensbidrag (11)
bokkapitel (2)
Typ av innehåll
refereegranskat (217)
övrigt vetenskapligt/konstnärligt (10)
populärvet., debatt m.m. (1)
Författare/redaktör
Johnson, R (9)
Kumar, S (8)
Thorsteinsdottir, Un ... (8)
Li, Y. (7)
Zhang, Y. (7)
King, D. (7)
visa fler...
Thorleifsson, Gudmar (7)
Olsson, Håkan (6)
Walker, R. (6)
Yang, Y. (6)
Kim, Y. (6)
Kim, J. (6)
Kirov, K (6)
Patel, A (6)
Chasman, Daniel I. (6)
van Duijn, Cornelia ... (6)
Chen, K. (5)
Nowak, S. (5)
Price, D. (5)
Wu, Y. (5)
Yu, J. (5)
Zhang, J. (5)
Marshall, R. (5)
Taylor, D (5)
Clark, M. (5)
Garcia, J. (5)
Lee, S (5)
Lewis, J (5)
Sander, C. (5)
Thomas, J. (5)
Ohara, M (5)
Hobirk, J (5)
Kappatou, A (5)
Lennholm, M (5)
Lerche, E (5)
Menmuir, S (5)
Valisa, M (5)
Maslov, M. (5)
Miyano, S (5)
Smith, J. (5)
Price, C (5)
Guigo, Roderic (5)
Ohlsson, Claes, 1965 (5)
Bishop, D Timothy (5)
Wareham, Nicholas J. (5)
Lee, C. (5)
Hopper, John L. (5)
Jones, C (5)
Ridker, Paul M. (5)
Borg, Åke (5)
visa färre...
Lärosäte
Uppsala universitet (70)
Karolinska Institutet (66)
Lunds universitet (64)
Göteborgs universitet (34)
Stockholms universitet (34)
Umeå universitet (24)
visa fler...
Linköpings universitet (21)
Kungliga Tekniska Högskolan (13)
Chalmers tekniska högskola (12)
Sveriges Lantbruksuniversitet (7)
Karlstads universitet (5)
Linnéuniversitetet (4)
Örebro universitet (3)
Jönköping University (2)
Högskolan Dalarna (2)
Luleå tekniska universitet (1)
Högskolan i Gävle (1)
Mälardalens universitet (1)
Mittuniversitetet (1)
Naturhistoriska riksmuseet (1)
VTI - Statens väg- och transportforskningsinstitut (1)
visa färre...
Språk
Engelska (230)
Italienska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (100)
Naturvetenskap (81)
Teknik (6)
Lantbruksvetenskap (4)
Samhällsvetenskap (4)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy