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| 2. |
- Dukic, Tania, 1975, et al.
(författare)
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To use virtual tools for further development of Volvo Car´s production system - A case study of the development of the production system for P28/XC90.
- 2002
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Ingår i: Chalmers, Produkt- och Produktionsutveckling. Rapport nr. 16. - 1651-0984. ; , s. 112-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- SummaryA work procedure for virtual product and manufacturing engineering has been developed at the Volvo Car Corporation. For the first time this was fully adhered to during the development of the P28/XC90 car model. The working methods comprise both virtual and physical analysis of different aspects of the product and production process, such as packing, assembly ability and ergonomics. A decision was taken in January 2001 to make an evaluation of the virtual working methods, for which a research team from the National Institute for Working Life and Chalmers University of Technology was engaged.The purpose was to evaluate how well the virtual working methods functioned with regard to ergonomics aspects of assembly work - and to what degree they could be applied for early identification of ergonomics problems. About 30 interviews with members of different development teams (module teams) were carried out for the evaluation. Evaluations of the assembly work for a selected number of PIIs1 for P28 were also made, starting with virtual series2 5 (VS5) in February 2001 ending with the pre-series PTO1 (Pre try-out 13) in November 2001. The overall results showed that the virtual participative working methods worked well in general and the members of the module teams (project teams) were very positive to the usage of virtual tools. A large number of ergonomic problems were identified and corrected but the number of ergonomic simulations was lower than expected. The reason for this was said to be a lack of ergonomics competence. Nevertheless the module teams believed that there was a greater potential for identifying and solving several ergonomic problems in early project phases than was the case in this study. An overall important outcome was the recommendations to the company for how to improve virtual working procedures, follow-ups of simulation results and virtual tools for the future.
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| 3. |
- Hanson, Lars, et al.
(författare)
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ANNIE, a Tool for Integrating Ergonomics in the Design of Car Interiors
- 2000
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Ingår i: SAE Transactions – Journal of Materials and Manufacturing. Technical Paper 1999-01-3372. Reprinted From: Proceedings of the 1999 SAE Southern Automotive Manufacturing.. ; , s. 1-11
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Konferensbidrag (refereegranskat)abstract
- An example of a result from a long-term cooperation with Lund University (together with professor Roland Akselsson at the Department for Work Environment) there some of the authors (Engström) gained extensive grants (Wallenberg Stifelsen regarding equipment as well as other founding from e.g. the Swedish Work Environment Found). In this case the just mentioned EU-financing.
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| 4. |
- Hansson, Lars, et al.
(författare)
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Annie, a Tool for Integrating Ergonomics in the Design of Car Interiors
- 1999
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- An example of a result from a long-term cooperation with Lund University (together with professor Roland Axelsson at the Department for Work Environment) there some of the authors. (Engström) gained extensive grants (Wallenberg Stifelsen regarding equipment as well as other founding from e.g. the Swedish Work Environment Found).
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| 5. |
- Hansson, Lars, et al.
(författare)
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Eye and Body Movements Characterized by Synchronized Sampling
- 1998
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- An example of a result from a long-term cooperation with Lund University (together with professor Roland Akselsson at the Department of Ergonomics and Aerosol Technology) there some of the authors. (Engström) gained extensive grants (EU-financing and Wallenberg Stifelsen regarding equipment as well as other founding from e.g. the Swedish Work Environment Found). This publication was a result of the just mentioned EU-financing.
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| 6. |
- Hansson, Lars, et al.
(författare)
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Mannequin Properties Desired for Ergonomic Evaluation of Car Interiors
- 1998
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- An example of a result from a long-term cooperation with Lund University (together with professor Roland Akselsson at the Department of Ergonomics and Aerosol Technology) there some of the authors. (Engström) gained extensive grants (EU-financing and Wallenberg Stifelsen regarding equipment as well as other founding from e.g. the Swedish Work Environment Found). This publication has emanated from an EU-financed research project.
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| 7. |
- Ilan, Ezgi, et al.
(författare)
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Comparison of 68Ga-DOTATATE and 177Lu-DOTATATE kinetics in neuroendocrine tumors
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Tidskriftsartikel (refereegranskat)abstract
- Absorbed dose planning prior peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE would allow maximization of the absorbed dose to tumor tissue whilst minimizing the risk for side-effects in healthy organs. Unfortunately, dosimetry during 177Lu-DOTATATE is only possible post therapy and using 68Ga-DOTATATE to act as surrogate for 177Lu-DOTATATE could potentially enable prediction of absorbed doses prior PRRT with 177Lu-DOTATATE. The aim of this study was to compare uptake and kinetics of 68Ga-DOTATATE and 177Lu-DOTATATE in tumors by performing dynamic or serial scans with both radiopharmaceuticals in the same patients. Methods Six NET patients underwent a 45-min dynamic PET scan after injection of 124 ±38 MBq 68Ga-DOTATATE and serial SPECT scans after a bolus injection of 500 ± 0 MBq 177Lu-DOTATATE assuring similar peptide content in the radiopharmaceuticals. Tumor and whole-blood SUV, tumor-to-blood-ratio (TBR), and net influx rate (Ki) were determined for 68Ga-DOTATATE and 177Lu-DOTATATE. Ki was determined by non-linear regression of an irreversible two-tissue compartment model with a loss parameter and by the Patlak method. Results In majority of tumors, tumor SUV was higher in 68Ga-DOTATATE than in 177Lu-DOTATATE and whole-blood SUV was lower in 68Ga-DOTATATE than in 177Lu-DOTATATE, resulting in a lower TBR for 68Ga-DOTATATE than for 177Lu-DOTATATE. For Ki, Spearman correlation was 0.55 between 68Ga- DOTATATE and 177Lu-DOTATATE with a Demining regression slope of 0.93. For Patlak based Ki (with correction for partial volume effect based on data <100 min p.i. for 177Lu-DOTATATE), the Spearman correlation was 0.90 and with a Deming regression slope close to 1 (0.83). Using a later time interval (with correction for partial volume effect based on data >100 min p.i) for the Patlak analysis also resulted in high correlation (0.87) but the Deming regression slope was 0.18. Conclusion Linear relation with good agreement was found between the SUVs of 68Ga-DOTATATE and 177Lu-DOTATATE. Similar Ki was observed for 68Ga-DOTATATE and 177Lu-DOTATATE during early time interval (<100 min p.i of 177Lu-DOTATATE) however not during late time interval (>100 min p.i.). Hence, late kinetics of 177Lu-DOTATATE cannot be predicted using 68Ga-DOTATATE PET.
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| 10. |
- Ilan, Ezgi, et al.
(författare)
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Parametric Net Influx Rate Images of 68Ga-DOTATOC and 68Ga-DOTATATE : Quantitative Accuracy and Improved Image Contrast
- 2017
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Ingår i: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 58:5, s. 744-749
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Tidskriftsartikel (refereegranskat)abstract
- (68)Ga-DOTATOC and (68)Ga-DOTATATE are radiolabelled somatostatin analogs used for diagnosis of somatostatin receptor expressing neuroendocrine tumors (NETs) and SUV -measurements are suggested for treatment monitoring. However, changes in net-influx rate (Ki) may better reflect treatment effects than those of the SUV, and accordingly there is a need to compute parametric images showing Ki at the voxel level. The aim of this study was to evaluate parametric methods for computation of parametric Ki images by comparison to volume of interest based methods and to assess image contrast in terms of tumor-to-liver ratio.METHODS: Ten patients with metastatic NETs underwent a 45-min dynamic PET examination followed by whole-body PET/CT at 1 h post injection of (68)Ga-DOTATOC and (68)Ga-DOTATATE on consecutive days. Parametric Ki images were computed using a basis function method (BFM) implementation of the two tissue irreversible compartment model and the Patlak method using a descending aorta image-derived input function, and mean tumor Ki values were determined for 50% isocontour VOIs and compared to Ki values based on non-linear regression (NLR) of the whole-VOI time-activity curve. A subsample of healthy liver was delineated in the whole-body and Ki images and tumor-to-liver ratios were calculated in order to evaluate image contrast. Correlation and agreement between VOI-based and parametric Ki values were assessed using regression and Bland-Altman analysis.RESULTS: Correlation (R2) between NLR-based and parametric image-based (BFM) tumor Ki values was 0.98 (slope 0.81) and 0.97 (slope 0.88) for (68)Ga-DOTATOC and (68)Ga DOTATATE, respectively. For Patlak analysis, correlation between NLR-based and parametric based (Patlak) tumor Ki were 0.95 (slope 0.71) and 0.92 (slope 0.74) for (68)Ga-DOTATOC and (68)Ga-DOTATATE, respectively. There was no bias between NLR and parametric based Ki-values. Tumor-to-liver contrast was 1.6 and 2.0 times higher in the parametric BFM-Ki images, and 2.3 and 3.0 times in the Patlak images, than in the whole-body images for (68)Ga-DOTATOC and (68)Ga-DOTATATE, respectively.CONCLUSION: A high correlation and agreement between NLR- and parametric based Ki values was found, showing that parametric net influx rate images are quantitatively accurate. In addition, tumor-to-liver contrast was superior in the parametric Ki images compared to whole-body images both for (68)Ga-DOTATOC and (68)Ga DOTATATE.
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