| 1. |
|
|
| 2. |
- Grankvist, Kjell, 1954-
(författare)
-
Mechanisms of alloxan diabetogenicity
- 1981
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Suspensions of pancreatic islet cells from ob/ob-mice were incubated with Trypan Blue. Microscope photometry showed that apparently viable cells excluded the dye completely, whereas the nuclei of non-viable cells accumulated Trypan Blue by a saturable process. Alloxan rapidly increased the permeability of the plasma membrane in mouse 3-cells; the exclusion of Trypan Blue is a valid and useful measure of islet cell viability following alloxan exposure.The diabetogenic action of alloxan may be mediated by hydroxyl radicals. In several biological systems hydroxyl radicals are formed by an iron-catalyzed reaction between superoxide anion radicals and hydrogen peroxide. To test whether this applies to alloxan diabetogenicity, the effects of superoxide dismutase, catalase, scavengers of hydroxyl radicals, and metal ion chelators were tested (a) in a cell-free radical-generating system and (b) on islets and islet-cells exposed to alloxan In vitro. The effect of longtime-circulating superoxide dismutase injected prior to alloxan was tested on mice in vivo.Luminol chemiluminescence was used to monitor alloxan-dependent radical production. Accumulation of 8^Rb+ and exclusion of Trypan Blue were used as cell viability criteria in isolated mouse islets and islet-cells. Blood glucose was determined to monitor the development of diabetes in living animals.Superoxide dismutase, catalase, scavengers of hydroxyl radicals, and metal ion chelators inhibited the alloxan-dependent chemiluminescence and decreased the toxic effects on Rb+ accumulation or Trypan Blue exclusion in islets and islet-cells. Superoxide dismutase, linked to polyethylene glycol and injected 12 hours before alloxan, largely prevented the development of alloxan diabetes.Alloxan toxicity _in vitro and in vivo seems to depend on the formation of superoxide radicals and hydrogen peroxide which in turn form the noxious hydroxyl radical via an iron-catalyzed Haber-Weiss reaction.As free radicals and hydrogen peroxide can be formed by other chemicals and during inflammation, and inflammation may accompany the outbreak of human diabetes, studies on the beneficiary effects of superoxide dismutase and other scavengers of free radicals in other forms of diabetes seem warranted.
|
|
| 3. |
|
|
| 4. |
- Täljedal, Inge-Bert, Professor, 1942-
(författare)
-
A note on Huemer's claim to immortality
- 2020
-
Ingår i: Principia. - : Universidade Federal de Santa Catarina. - 1414-4247 .- 1808-1711. ; 24:3, s. 657-659
-
Tidskriftsartikel (refereegranskat)abstract
- According to Huemer (2019), existence is evidence of immortality, provided past time is infinite. The argument is based on, inter alia, an alleged contradiction between the fact of one’s existence now and its improbability. I suggest that Huemer’s argument is flawed in equating the infinitesimally small with its limit value, and in assuming a philosophically significant difference between the a priori probability of the occurrence of a unique incarnation and that of anyone among an infinite number.
|
|
| 5. |
- Täljedal, Inge-Bert, Professor, 1942-
(författare)
-
Att göra sig en bild
- 1988
-
Ingår i: Vetenskapliga bilder. - Umeå : Bildmuseet, Umeå universitet. ; , s. 2-2
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 6. |
- Täljedal, Inge-Bert, Professor, 1942-
(författare)
-
Burmanföreläsningarna
- 2023. - 2
-
Ingår i: Humaniora. - Umeå : Umeå University. - 9789178559640 - 9789178559657 ; , s. 196-197
-
Bokkapitel (populärvet., debatt m.m.)
|
|
| 7. |
- Täljedal, Inge-Bert, Professor, 1942-
(författare)
-
C. J. Boströms språkbevis för idealismen
- 2023
-
Ingår i: Filosofisk Tidskrift. - Stockholm : Thales. - 0348-7482. ; 44:4, s. 43-47
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 8. |
- Täljedal, Inge-Bert, Professor, 1942-
(författare)
-
Christopher Jacob Boström’s Pre-Fregean Dual Conception of Meaning
- 2013
-
Ingår i: Johanssonian Investigations. - Heusenstamm : Ontos Verlag. - 9783868381900 - 9783110322507 ; , s. 676-695
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In 1859–1860, Johan Jacob Borelius published two diatribes against Christopher Jacob Boström, the then dominating philosopher in Sweden. Boström was accused of inconsistency, because he asserted the principle of esse est percipi while at the same time maintaining that different agents can perceive one and the same thing differently. It is suggested that Borelius misunderstood Boström’s intention. In his printed defence, in 1860, Boström clarifies his use of a dual conception of meaning, resembling Frege’s distinction between Sinn (sense) and Bedeutung (reference) some thirty years later. Boström appears to equate the reference of esse with that of percipi, whereas Borelius argued as if the principle concerned the senses of the two expressions. According to Borelius, two observers cannot possibly have different perceptions of the same object, if “to be” means “to be perceived”. In Boström’s view, as reconstructed here, two different phenomenal perceptions may well refer to one and the same true object, of which the phenomena are aspects. The true object exists in virtue of its being determined by God’s perfect ideas.
|
|
| 9. |
- Täljedal, Inge-Bert, 1942-
(författare)
-
Esse est percpi and percept identity in C. J. Boström's philosophy
- 2013
-
Ingår i: Idealistic Studies. - Worcester, MA, USA : Clark University Press. - 0046-8541 .- 2153-8239. ; 43:1-2, s. 63-70
-
Tidskriftsartikel (refereegranskat)abstract
- Berkeley's 'esse is percipi' has been criticized for implying epistemological solipsism, the main argument being that different minds cannot harbor numerically one and the same idea. Similarly, C. J. Boström, the dominating Swedish philosopher in the 19th century, was early scorned because his principle of esse est percipi allegedly contradicts the simultaneous claim that two spirits (God and a human, or two humans) can perceive the same thing under qualitatively different appearances. Whereas the criticism against Berkeley is here regarded as valid, it is argued that Boström successfully defended himself by employing a dual concept of meaning, resembling Frege's Sinn and Bedeutung some thirty years later, and by postulating an ontology that permits human minds to share in the divine ideas that constitute reality.
|
|
| 10. |
- Täljedal, Inge-Bert, Professor, 1942-
(författare)
-
L'idea di similitudine in Antonio Rosmini
- 2023
-
Ingår i: Le repos de la guerrière. - Umeå : Umeå University. - 9789180702447 - 9789180702454 ; , s. 125-137
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Secondo Antonio Rosmini-Serbati, l’idea dell’essere è unicamente innata e forma fondamentale dell’esperienza. Provando a dimostrare l’origine dell’idea di similitudine nel rapporto tra cose reali e loro rappresentazioni mentali, Rosmini involontariamente lascia pensare che forse anche quest’idea sia innata. In modo platonico respinge “il terzo uomo” (regresso infinito), cioè la nota critica di Aristotele per quanto riguarda l’idea di similitudine. Il suo è un ragionamento circolare. Perciò in questa analisi concludiamo che l’idea di similitudine dovrebbe essere considerata innata e forma epistemologica nella stessa misura dell’idea di essere.
|
|
