| 1. |
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| 2. |
- Bousquet, J, et al.
(författare)
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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
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Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
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Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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| 3. |
- Richards, A. M. S., et al.
(författare)
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ALMA sub-mm maser and dust distribution of VY Canis Majoris
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 572
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Cool, evolved stars have copious, enriched winds. Observations have so far not fully constrained models for the shaping and acceleration of these winds. We need to understand the dynamics better, from the pulsating stellar surface to similar to 10 stellar radii, where radiation pressure on dust is fully effective. Asymmetric nebulae around some red supergiants imply the action of additional forces. Methods. We retrieved ALMA Science Verification data providing images of sub-mm line and continuum emission from VY CMa. This enables us to locate water masers with milli-arcsec accuracy and to resolve the dusty continuum. Results. The 658, 321, and 325 GHz masers lie in irregular, thick shells at increasing distances from the centre of expansion. For the first time this is confirmed as the stellar position, coinciding with a compact peak offset to the NW of the brightest continuum emission. The maser shells overlap but avoid each other on scales of up to 10 au. Their distribution is broadly consistent with excitation models but the conditions and kinematics are complicated by wind collisions, clumping, and asymmetries.
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| 4. |
- Amada, K., et al.
(författare)
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Discovery of SiO Masers in the "Water Fountain" Source IRAS 16552-3050
- 2022
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 1538-3881 .- 0004-6256. ; 163:2
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we report new detections of SiO v = 1 and v = 2 J = 1 -> 0 masers in the "water fountain" source IRAS 16552-3050, which was observed with the Nobeyama 45 m telescope during 2021 March-April. Water fountains are evolved stars whose H2O maser spectra trace high-velocity outflows of >100 km s(-1). This is the second known case of SiO masers in a water fountain, after their prototypical source, W 43A. These SiO masers should shed light on the evolutionary status of this category of evolved stars, which are likely to be at the end of the asymptotic giant branch phase, when the star exhibits the most copious stellar mass loss, followed by development of the complicated morphologies of planetary nebulae. The origin of a large (up to 25 km s(-1)) velocity offset of the SiO masers with respect to the systemic velocity derived from the spectrum of CO J = 2 -> 1 line is discussed here.
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| 5. |
- Amada, Kei, et al.
(författare)
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Discovery of SiO masers in the Water Fountain source, IRAS 16552-3050
- 2022
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 18, s. 359-361
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Konferensbidrag (refereegranskat)abstract
- We report new detections of SiO ν = 1 and ν = 2 J = 1 → 0 masers in the water fountain source IRAS 16552-3050, which was observed with the Nobeyama 45 m telescope from March 2021 to April 2023. Water fountains are evolved stars whose H2O maser spectra trace high-velocity outflows of >100 Km s-. This is the second known case of SiO masers in a water fountain, after their prototypical source, W 43A. The line-of-sight velocity of the SiO masers are blue-shifted by ∼25 km s-1 from the systemic velocity. This velocity offset imply that the SiO masers are associated with nozzle structure formed by a jet penetrating the circumstellar envelope, and that new gas blobs of the jet erupted recently. Thus, the SiO masers imply this star to be in a new evolutionary stage.
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| 6. |
- Imai, H., et al.
(författare)
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FLASHING: New high-velocity H2O masers in IRAS 18286−0959
- 2020
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Ingår i: Publication of the Astronomical Society of Japan. - : Oxford University Press (OUP). - 2053-051X .- 0004-6264. ; 72:4
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Tidskriftsartikel (refereegranskat)abstract
- We discovered new high-velocity components of H2O maser emission in one of the “water fountain” sources, IRAS 18286−0959, which has been monitored using the Nobeyama 45 m telescope in the FLASHING (Finest Legacy Acquisitions of SiO- and H2O-maser Ignitions by Nobeyama Generation) project since 2018 December. The maser spectra show new components with extremely high expansion velocities (>200 km s−1 projected in the line of sight), some of which are located symmetrically in the spectrum with respect to the systemic velocity. They were also mapped with KaVA (KVN and VERA Combined Array) in 2019 March. We located some of these maser components closer to the central stellar system than other high-velocity components (50-200 km s−1) that have been confirmed to be associated with the known bipolar outflow. The new components would have flashed in the fast collimated jet at a speed of over 300 km s−1 (soon) after 2011 when they had not been detected. The fastest of the new components seem to indicate rapid deceleration in these spectra; however, our present monitoring is still too sparse to unambiguously confirm it (up to 50 km s−1 yr−1) and too short to reveal their terminal expansion velocity, which will be equal to the expansion velocity that has been observed (vexp ∼ 120 km s−1). Future occurrences of such extreme-velocity components may provide a good opportunity to investigate possible recurrent outflow ignitions. Thus, the sculpture of the parental envelope will be traced by the dense gas that is entrained by the fast jet and exhibits spectacular distributions of the relatively stable maser features.
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| 7. |
- Imai, H., et al.
(författare)
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Water and silicon-monoxide masers monitored towards the water fountain sources
- 2021
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 17, s. 91-93
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Konferensbidrag (refereegranskat)abstract
- We have investigated the evolution of 12 water fountain sources in real time in the accompanying H2O 2o and SiO masers through our FLASHING (Finest Legacy Acquisitions of SiO-/ H2O 2o-maser Ignitions by Nobeyama Generation) project. It has been confirmed that these masers are excellent probes of new jet blob ejections, acceleration of the material supplied from the parental circumstellar envelope and entrained by the stellar jets yielding its deceleration. Possible periodic variations of the maser emission, reflecting properties of the central dying stars or binary systems, will be further investigated.
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| 8. |
- Imai, Hiroshi, et al.
(författare)
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Water Fountain Sources Monitored in FLASHING
- 2022
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 18, s. 333-337
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Konferensbidrag (refereegranskat)abstract
- We have investigated the spectral evolutions of H2O and SiO masers associated with 12 water fountain sources in our FLASHING (Finest Legacy Acquisitions of SiO-/H2O-maser Ignitions by Nobeyama Generation) project. Our monitoring observations have been conducted using the Nobeyama 45 m telescope every 2 weeks-2 months since 2018 December except during summer seasons. We have found new extremely high velocity H2O maser components, breaking the records of jet speeds in this type of sources. Systematic line-of-sight velocity drifts of the H2O maser spectral peaks have also been found, indicating acceleration of the entrained material hosting the masers around the jet. Moreover, by comparing with previous spectral data, we can find decadal growths/decays of H2O maser emission. Possible periodic variations of the maser spectra are further being inspected in order to explore the periodicity of the central stellar system (a pulsating star or a binary). Thus we expect to see the real-time evolution/devolutions of the water fountains over decades.
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| 9. |
- Uscanga, L., et al.
(författare)
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Evolution of the Outflow in the Water Fountain Source IRAS 18043-2116
- 2023
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 948:1
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Tidskriftsartikel (refereegranskat)abstract
- We present the spectral and spatial evolution of H2O masers associated with the water fountain source IRAS 18043-2116, found in observations with the Nobeyama 45 m Telescope and the Australia Telescope Compact Array. We have found new highest-velocity components of the H2O masers (at the redshifted side V (LSR) similar or equal to 376 km s(-1) and at the blueshifted side V (LSR) similar or equal to -165 km s(-1)), and the resulting velocity spread of similar or equal to 540 km s(-1) breaks the speed record of fast jets/outflows in this type of sources. The locations of those components have offsets from the axis joining the two major maser clusters, indicating a large opening angle of the outflow (similar to 60 degrees). The evolution of the maser cluster separation of similar to 2.9 mas yr(-1) and the compact (similar to 0.'' 2) CO emission source mapped with the Atacama Large Millimeter-submillimeter Array suggest a very short (similar to 30 yr) timescale of the outflow. We also confirmed an increase in the flux density of the 22 GHz continuum source. The properties of the jet and the continuum sources and their possible evolution in the transition to the planetary nebula phase are further discussed.
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| 10. |
- Uscanga, L., et al.
(författare)
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Evolution of the outflow traced by water masers in the evolved star IRAS 18043 - 2116
- 2022
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 18, s. 338-342
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Konferensbidrag (refereegranskat)abstract
- We present the spectral and spatial evolution of H2O masers associated with IRAS 18043-2116, a well-known water fountain hosting a high-velocity collimated jet, which has been found in the observations with the 45 m telescope of Nobeyama Radio Observatory and the Australia Telescope Compact Array. We found new highest velocity components of the H2O masers, with which the resulting velocity spread of ≃ 540 km s-1 breaks the speed record of fast jets/outflows in this type of sources.
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