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- Borch, Kurt, 1944-, et al.
(författare)
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Prevalence of coeliac disease and relations to Helicobacter pylori infection and duodenitis in a Swedish adult population sample : A histomorphological and serological survey
- 2000
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Ingår i: InflammoPharmacology. - : Springer Science and Business Media LLC. - 0925-4692 .- 1568-5608. ; 8:4, s. 341-350
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of this study was to determine the prevalence of coeliac disease and its relation to duodenitis, H. pylori infection and gastritis in a sample of the adult general population. Methods: A Swedish population sample of 482 subjects (aged 35 to 85 years) were examined with gastro-duodenoscopy with multiple biopsies taken. Circulating antibodies to endomycium, gliadin, and H. pylori were also determined. Results: Based on histomorphological findings, coeliac disease was evident in 9 of 482 subjects giving a prevalence of 1.9 [1.0-4.0, 95% confidence interval] percent. The prevalence of gastritis with or without H. pylori infection did not differ between subjects with and without coeliac disease. Considering subjects without coeliac disease, there was no difference in the serum levels of gliadin antibodies between those with and without duodenitis. However, subjects with positive H. pylori status had significantly higher levels of gliadin antibodies than those with negative H. pylori status. Conclusions: This study confirms that there is a relatively high prevalence of undiagnosed coeliac disease in Swedish adults. There was no association between coeliac disease and H. pylori infection or gastritis, although serum gliadin antibody levels were slightly increased in subjects with positive H. pylori status.
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| 2. |
- Stacey, Simon N, et al.
(författare)
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A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:11, s. 1098-103
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Tidskriftsartikel (refereegranskat)abstract
- To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide association study of 16 million SNPs identified through whole-genome sequencing of 457 Icelanders. We imputed genotypes for 41,675 Illumina SNP chip-typed Icelanders and their relatives. In the discovery phase, the strongest signal came from rs78378222[C] (odds ratio (OR) = 2.36, P = 5.2 × 10(-17)), which has a frequency of 0.0192 in the Icelandic population. We then confirmed this association in non-Icelandic samples (OR = 1.75, P = 0.0060; overall OR = 2.16, P = 2.2 × 10(-20)). rs78378222 is in the 3' untranslated region of TP53 and changes the AATAAA polyadenylation signal to AATACA, resulting in impaired 3'-end processing of TP53 mRNA. Investigation of other tumor types identified associations of this SNP with prostate cancer (OR = 1.44, P = 2.4 × 10(-6)), glioma (OR = 2.35, P = 1.0 × 10(-5)) and colorectal adenoma (OR = 1.39, P = 1.6 × 10(-4)). However, we observed no effect for breast cancer, a common Li-Fraumeni syndrome tumor (OR = 1.06, P = 0.57, 95% confidence interval 0.88-1.27).
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| 3. |
- Valdimarsson, Trausti
(författare)
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Bone in coeliac disease
- 1999
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Patients with untreated and treated coeliac disease were examined regarding bone mineral density (BMD) and biochemical factors of importance for bone metabolism. The occurrence of disturbances and their correction during treatment with a gluten-free diet were studied. BMD was measured in the forearm using single photon absorptiometry and in the hip and spine using dual-energy X-ray absorptiometry.Among the 288 adult patients with known coeliac disease in our catchment area, 13 patients with persistent villous atrophy of the proximal small bowel mucosa despite dietary recommendation were identified and compared with matched control-patients whose intestinal mucosa had normalised at least 4 years earlier. BMD was reduced in patients with persistent villous atrophy but within normal limits in patients responsive to the diet.In 105 adult patients with untreated coeliac disease, HN.ID was reduced compared to a local healthy control group. During the first year on a gluten-free diet the BMD increased rapidly (by a median of 3 %in the spine) even in patients with minor symptoms and in older patients. Secondary hyperparathyroidism was found in 27% of untreated patients and these patients had more severely reduced BMD compared to those with normal initial parathyroid hormone. Twenty-three % of the untreated patients also had low serum calcidiol (25-hydroxyvitarnin D) levels. BMD continued to increase in the second and third follow-up years, but only became normal within three years in the group of patients without initial secondary hyperparathyroidism.In 29 consecutive adult patients with untreated coeliac disease, serum insulin-like growth factor I and BMD were lower than in matched controls. In 14 untreated patients with normal parathyroid hormone values the increase in insulin-like growth factor I correlated positively to the increase in BMD during the first year after starting a gluten-free diet.In 46 adult patients with coeliac disease trt;atedfor 8-12 years in routine care, median BMD was normal but five patients who did not follow strict gluten-free diet had a lower BMD in the femoral neck than the group of 41 patients who claimed strict adherence.TI1ese studies show that untreated coeliac disease is associated with a low B:MD. BMD inereases rapidly when a gluten-free diet is followed, even in older patients. Circulating insulin-like growth factor I may reflect some changes in hone metabolism but its pathogenetic role behind the low BMD seen in adults with coeliac disease is unclear. Secondary hyperparathyroidism is common and vitamin D deficiency also seems to be an important underlying mechanism. These findings underline the importance of a gluten-free diet for all patients with coeliac disease.
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