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- Nijs, Jo, et al.
(författare)
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Nociceptive, neuropathic, or nociplastic low back pain? : The low back pain phenotyping (BACPAP) consortium's international and multidisciplinary consensus recommendations
- 2024
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Ingår i: LANCET RHEUMATOLOGY. - : Elsevier. - 2665-9913. ; 6:3, s. e178-e188
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Tidskriftsartikel (refereegranskat)abstract
- The potential to classify low back pain as being characterised by dominant nociceptive, neuropathic, or nociplastic mechanisms is a clinically relevant issue. Preliminary evidence suggests that these low back pain phenotypes might respond differently to treatments; however, more research must be done before making specific recommendations. Accordingly, the low back pain phenotyping (BACPAP) consortium was established as a group of 36 clinicians and researchers from 13 countries (five continents) and 29 institutions, to apply a modified Nominal Group Technique methodology to develop international and multidisciplinary consensus recommendations to provide guidance for identifying the dominant pain phenotype in patients with low back pain, and potentially adapt pain management strategies. The BACPAP consortium's recommendations are also intended to provide direction for future clinical research by building on the established clinical criteria for neuropathic and nociplastic pain. The BACPAP consortium's consensus recommendations are a necessary early step in the process to determine if personalised pain medicine based on pain phenotypes is feasible for low back pain management. Therefore, these recommendations are not ready to be implemented in clinical practice until additional evidence is generated that is specific to these low back pain phenotypes.
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- Croxatto Vega, G., et al.
(författare)
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Insights from combining techno-economic and life cycle assessment – a case study of polyphenol extraction from red wine pomace
- 2021
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Ingår i: Resources, Conservation and Recycling. - : Elsevier B.V.. - 0921-3449 .- 1879-0658. ; 167
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Tidskriftsartikel (refereegranskat)abstract
- To determine the environmental and economic performance of emerging processes for the valorization of red wine pomace, a techno-economic assessment (TEA) and a Life Cycle Assessment (LCA) are combined at an early design stage. A case study of two polyphenol extraction methods at laboratory scale, solvent extraction (SE) and pressurized liquid extraction (PLE), were first analyzed via a carbon footprint (CFP). Subsequently, the laboratory scale design was improved and translated into industrial scale and a TEA was performed on the industrial scale designs. Finally, LCA was applied again with all impact indicators and the information gathered from both the TEA and LCA was combined into concise decision support, using Multiple Criteria Decision Analysis (MCDA). SE performs better than PLE, due to a lower solvent to DW ratio and a less expensive processing setup in both environmental and economic terms. The CFP of at laboratory scale aided in showing potential environmental hotspots and highlighted the need to reduce solvent use. The MCDA showed a shift in decision support depending on how strongly economic or environmental benefits are valued and eases the interpretation of the 19 different indicators derived from the TEA-LCA results. Both SE and PLE with a solvent to dry weight (DW) ratio of 5 and 10, respectively, perform competitively while SE with a solvent to DW ratio of 10 outperforms PLE with a solvent to DW ratio of 25. The case study illustrated how early design calculations (CFP), and combined LCA and TEA may be combined to improve process design.
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