| 1. |
- Bridel, Claire, et al.
(författare)
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Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology : A Systematic Review and Meta-analysis
- 2019
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Ingår i: JAMA Neurology. - : American Medical Association (AMA). - 2168-6149 .- 2168-6157. ; 76:9, s. 1035-1048
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Forskningsöversikt (refereegranskat)abstract
- Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disorders have not been compared systematically to date.Objectives To assess the associations of age, sex, and diagnosis with NfL in CSF (cNfL) and to evaluate its potential in discriminating clinically similar conditions.Data Sources PubMed was searched for studies published between January 1, 2006, and January 1, 2016, reporting cNfL levels (using the search terms neurofilament light and cerebrospinal fluid) in neurological or psychiatric conditions and/or in HC.Study Selection Studies reporting NfL levels measured in lumbar CSF using a commercially available immunoassay, as well as age and sex.Data Extraction and Synthesis Individual-level data were requested from study authors. Generalized linear mixed-effects models were used to estimate the fixed effects of age, sex, and diagnosis on log-transformed NfL levels, with cohort of origin modeled as a random intercept.Main Outcome and Measure The cNfL levels adjusted for age and sex across diagnoses.Results Data were collected for 10 059 individuals (mean [SD] age, 59.7 [18.8] years; 54.1% female). Thirty-five diagnoses were identified, including inflammatory diseases of the central nervous system (n = 2795), dementias and predementia stages (n = 4284), parkinsonian disorders (n = 984), and HC (n = 1332). The cNfL was elevated compared with HC in a majority of neurological conditions studied. Highest levels were observed in cognitively impaired HIV-positive individuals (iHIV), amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and Huntington disease. In 33.3% of diagnoses, including HC, multiple sclerosis, Alzheimer disease (AD), and Parkinson disease (PD), cNfL was higher in men than women. The cNfL increased with age in HC and a majority of neurological conditions, although the association was strongest in HC. The cNfL overlapped in most clinically similar diagnoses except for FTD and iHIV, which segregated from other dementias, and PD, which segregated from atypical parkinsonian syndromes.Conclusions and Relevance These data support the use of cNfL as a biomarker of neuroaxonal damage and indicate that age-specific and sex-specific (and in some cases disease-specific) reference values may be needed. The cNfL has potential to assist the differentiation of FTD from AD and PD from atypical parkinsonian syndromes.
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| 2. |
- Avelin, Anders, 1966-, et al.
(författare)
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Effect of different renovation actions, their investment cost and future potential
- 2017
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Ingår i: Energy Procedia. - : Elsevier Ltd. - 1876-6102. ; 143, s. 73-79
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Tidskriftsartikel (refereegranskat)abstract
- 65% of the buildings in Västerås, situated in the region of Mälardalen, Sweden were built before 1970. It is thus time for renovation. The situation is the same in most cities in Sweden and Northern Europe. The depth of renovation can be quite different. In this paper we evaluate some examples where cost is compared to energy saving effect. How to plan renovation to make use of the available capital in the cities is discussed. As a complement to direct renovation actions also behavior change with respect to energy is discussed and exemplified. The cost for energy actions in relation to other renovation aspects is discussed especially for the passive house case in Allingsås, Sweden. The passive house center calculate an extra cost for passive house standard to be 10 000 €/apartment while an external consultant has the figure 40 000 € of the total cost of 120 000 €. With this space heating can be 18 kWh/m2.year, or a reduction by 84 % with respect to space heating and 62% for overall heat and hot water demand. If you use the latter cost figure passive house standard is not motivated from an energy savings perspective while if using the lower figure it is very interesting. For the other less deep renovations we see that adding more insulation and three glass windows is motivated if the degradation has been strong, while a simpler renovation may be ok if the outer surface coating is not too bad. For these less deep renovations we see cost figures of 65 €/m2 respectively 28 €/m2 with reduction of heating and hot water demand of 56 % respectively 34 %.
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| 3. |
- Bian, Caiyun, et al.
(författare)
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Finding the optimal location for public charging stations - A GIS-based MILP approach
- 2019
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Ingår i: Energy Procedia. - : Elsevier Ltd. - 1876-6102. ; , s. 6582-6588
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Konferensbidrag (refereegranskat)abstract
- Electric Vehicles (EVs) have achieved a significant development because of the continuous technology revolution and policy supports in recent years, which leads to a larger demand of charging stations. Strategies about how to find the optimal location for charging facilities are urgently needed in order to further assist the development of EVs. This paper focus on the return of investments on EV charging stations and proposes a Mixed Integer Linear Programming (MILP) model based on Geographic Information System (GIS) to identify the optimal location of charging stations in cities. Traffic flow data and land-use classifications are used as important inputs, and six important constraints are included in the MILP model with the objective function of maximizing the total profits of new charging stations. The effectiveness of the proposed method is then demonstrated by implementing a case study in Västerås, Sweden.
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| 4. |
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| 5. |
- Chirumalla, Koteshwar, Associate Professor, et al.
(författare)
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Circular Business Models for the Electric Vehicle Battery Second Life : Navigating Battery Ecosystem Actors Towards Circularity
- 2024
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The electrification of vehicles has become a critical means to achieve climate-neutral transportation. As more electric vehicles (EV) are adopted, an increasing number of lithiumion batteries will be utilized, inevitably experiencing capacity degradation over time. Retaining the value of these retired batteries through remanufacturing, reusing, and repurposing to create a second life holds significant environmental and economic benefits. However, many companies within the battery ecosystem struggle to capitalize on this opportunity due to a lack of business insight and suitable business models tailored to their operational contexts.The ReCreate (Second Life Management of Electric Vehicle Batteries) research project was initiated to address these industrial needs through close collaboration with selected companies in the battery ecosystem. The project aims to define appropriate circular business models, methods, and processes to guide battery ecosystem actors in developing and implementing electric vehicle battery second life solutions, thereby advancing circularity around batteries and climate-neutral objectives. This handbook represents the culmination of three years of research within the ReCreate project. Its purpose is to present a simplified and practical overview of project outcomes across a series of key chapters. Comprising six chapters, the handbook will begin by discussing barriers and enablers, followed by circular business models and battery ecosystem management. It will then delve into design principles and performance monitoring guidelines, concluding with an integrated framework for second life and circular solutions for EV batteries. Each chapter briefly presents the main findings of the theme and concludes with discussion questions. The discussion questions include suggestions for relevant templates for workshops, and all templates are conveniently provided in the appendix for practical application. These templates serve as boundary objects, offering a starting point for internal and external cross-functional and cross-organizational dialogues within the electric vehicle battery ecosystem. They facilitate discussions and collaborations among various stakeholders, fostering alignment and synergy in developing circular business models for the second life of EV batteries. By facilitating reflection on current business strategies, needs, and pain points, the handbook aims to aid in the definition of future second life business strategies. We anticipate that this handbook will serve as a valuable resource for actors within the EV battery ecosystem, supporting their journey towards climate-neutral transportation.
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| 6. |
- Chirumalla, Koteshwar, Associate Professor, et al.
(författare)
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Configurations for second-life operations of electric vehicle batteries : A guiding framework for ecosystem management
- 2022
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Konferensbidrag (refereegranskat)abstract
- Firms need multi-stakeholder ecosystems to create successful second-life business models for electric vehicle (EV) batteries. However, there is a lack of guiding instrumentsto support the process of strategizing and managing the EV battery ecosystem for secondlife operations. The purpose of this study is to propose a guiding framework that could support firms in the EV battery ecosystem to establish and manage various configurations for second-life operations. The study developed a framework with four configuration phases—namely, firm-level initiation, ecosystem construction, firm-level optimization, and ecosystem orchestration. Based on these phases, the paper describes three configuration pathways to establish and manage second-life operations
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| 7. |
- Dahlquist, Erik, 1951-, et al.
(författare)
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Balancing Power in Sweden Using Different Renewable Resources, Varying Prices, and Storages Like Batteries in a Resilient Energy System
- 2023
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Ingår i: Energies. - 1996-1073. ; 16:12, s. 4734-4734
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, balancing electricity production using renewable energy such as wind power, PV cells, hydropower, and CHP (combined heat and power) with biomass is carried out in relation to electricity consumption in primarily one major region in Sweden, SE-3, which contains 75% of the country's population. The time perspective is hours and days. Statistics with respect to power production and consumption are analyzed and used as input for power-balance calculations. How long periods are with low or high production, as well as the energy for charge and discharge that is needed to maintain a generally constant power production, is analyzed. One conclusion is that if the difference in production were to be completely covered with battery capacity it would be expensive, but if a large part of the difference were met by a shifting load it would be possible to cover the rest with battery storage in an economical way. To enhance the economy with battery storage, second-life batteries are proposed to reduce the capital cost in particular. Batteries are compared to hydrogen as an energy carrier. The efficiency of a battery system is higher than that of hydrogen plus fuel cells, but in general much fewer precious materials are needed with an H-2/fuel-cell system than with batteries. The paper discusses how to make the energy system more robust and resilient.
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| 8. |
- Dong, Shuaili, et al.
(författare)
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Volatility of electricity price in Denmark and Sweden
- 2019
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Ingår i: INNOVATIVE SOLUTIONS FOR ENERGY TRANSITIONS. - : ELSEVIER SCIENCE BV. ; , s. 4331-4337
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Konferensbidrag (refereegranskat)abstract
- Under the pressure of global environmental climate change, all countries in the world are developing renewable energy such as hydropower, wind energy, and solar energy As a result, the electricity price varies in different patterns depending on the penetration of renewable energy. In this paper, a non-parametric model is employed to analyze the historical data of electricity spot price from Danish price areas of the Nord Pool (with high percentage of wind power), Swedish price areas of the Nord Pool (with high percentage of hydropower) and PJM market (with little renewable energy penetrated). The objective is to deeply understand the influence of renewable energies on electricity price volatility. It is found that electricity prices are more stable in Swedish price areas as hydropower is a more stable energy source. The electricity price in PJM market is also comparatively stable, only more volatile than Swedish market, as fossil fuels are dominant energy resources. For Danish price areas, the volatility of electricity prices is clearly affected by wind power, which is a highly intermittent energy resource.
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| 9. |
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| 10. |
- Ghaviha, Nima
(författare)
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Increasing Energy Efficiency in Electric Trains Operation : Driver Advisory Systems and Energy Storage
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Electric traction is the most efficient traction system in the railway transportation. However, due to the expensive infrastructure and high power demand from the grid, the share of electric trains in the railway transportation is still lower than other trains. Two of the possible solutions to increase the share of electric trains are: optimal train operation to minimize energy consumption, the use of batteries as the energy source for driving electric trains on non-electrified lines. This thesis aims to extend the knowledge in the field of energy optimal operation of electric trains and battery-driven electric trains.Energy optimal operation of electric trains is supervised using a driver advisory system (DAS), which instructs the driver to operate the train in an energy-efficient manner. This thesis contributes to DAS technology under two topics: the increase of energy efficiency and the design of DAS.This thesis presents a complete procedure of designing a DAS from the mathematical formulation to application on the train. The designed DAS is in the form of an Android application and is based on a dynamic programming approach. The computational performance of the approach is enhanced using heuristic state reducing rules based on the physical constraints of the system. The application of the DAS shows a potential reduction of 28% in energy consumption.This thesis considers the detailed energy losses in the whole propulsion system using a regression model that is generated from validated physical models. The application of the regression model instead of a previous constant efficiency factor model results in 2.3% reduction in energy consumption of the optimum speed profiles.Based on the solution for the normal electric trains, a solution is also offered for the optimal operation of battery-driven electric trains, in which the characteristics of the battery as one of the main components are considered using an electrical model. The solution presented in this thesis, is to combine the popular single mass point train model with an electrical circuit battery model.Furthermore, this thesis evaluates the performance of the optimization approaches and validates the models against the measurements from actual drives of a real-life battery train. The results show a potential of around 30% reduction in the charge consumption of the battery.The results of this thesis (algorithms and the Android application) are provided as open source for further research in the field of energy efficient train control.
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