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1.	Bediako, Y, et al. (author) INVESTIGATING IMMUNE SIGNATURES IN MALARIA-EXPOSED CHILDREN 2018 In: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. - 0002-9637. ; 99:4, s. 431-432 Conference paper (other academic/artistic)
2.	Bediako, Y, et al. (author) Repeated clinical malaria episodes are associated with modification of the immune system in children 2019 In: BMC medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 17:1, s. 60- Journal article (peer-reviewed)
3.	Aye, R, et al. (author) Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype 2020 In: European journal of immunology. - : Wiley. - 1521-4141 .- 0014-2980. ; 50:8, s. 1187-1194 Journal article (peer-reviewed)
4.	Rono, J, et al. (author) Multiple clinical episodes of Plasmodium falciparum malaria in a low transmission intensity setting: exposure versus immunity 2015 In: BMC medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 13, s. 114- Journal article (peer-reviewed)
5.	Ndungu, FM, et al. (author) A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01 E on blood stage immunity in young Kenyan children 2019 In: Wellcome open research. - : F1000 Research Ltd. - 2398-502X. ; 4, s. 42- Journal article (peer-reviewed)abstract Background: RTS,S/AS01 E, the most advanced malaria vaccine confers partial immunity. The vaccine-induced pre-erythrocytic immunity reduces exposure to blood-stage parasites, delaying acquisition of antibodies to blood-stage antigens. However, the duration of this effect is unknown. Methods: We measured, by enzyme-linked immunosorbent assay, IgG-antibodies to 4 Plasmodium falciparum blood-stage antigens (AMA1, MSP142, EBA175, and MSP3) on 314 children randomized to receive RTS,S/AS01 E or Rabies vaccine at 5 – 17 months of age in a phase 2b trial in Kenya, and thereafter participated in a 7-year study of the duration of vaccine immunity. Results: Antibody levels to MSP142, AMA1 and EBA175 were slightly lower among the RTS,S/AS01 E recipients, relative to the Rabies-control vaccinees, during the first 48 months of surveillance. Irrespective of vaccine arm, antibody levels to merozoite antigens were positively associated with the risk for malaria. However, this was only apparent at high levels for EBA175 and AMA1 and was not evident after adjusting for heterogeneity in malaria-exposure. Among children with asymptomatic parasitaemia, antibody levels were associated with reduced clinical malaria. Conclusions: The reduction in levels of antibodies to blood-stage antigens induced by vaccination with RTS,S/AS01 E can last for several years. In absence of asymptomatic infection, anti-merozoite antibody levels were unreliable correlates of clinical immunity.
6.	Tan, J, et al. (author) A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens 2016 In: Nature. - 1476-4687. ; 529:7584, s. 105- Journal article (peer-reviewed)
7.	Bediako, Y, et al. (author) The effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum - an epidemiological "natural experiment" 2016 In: BMC medicine. - 1741-7015. ; 14:1, s. 143- Journal article (peer-reviewed)
8.	Bejon, P, et al. (author) Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya 2010 In: PLoS medicine. - : Public Library of Science (PLoS). - 1549-1676. ; 7:7, s. e1000304- Journal article (peer-reviewed)
9.	Ndungu, FM, et al. (author) Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models 2015 In: BMC medicine. - 1741-7015. ; 13, s. 183- Journal article (peer-reviewed)

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Result 1-9 of 9

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Type of publication: journal article (8); conference paper (1)

Type of content: peer-reviewed (8); other academic/artistic (1)

Author/Editor: Wambua, J (9); Marsh, K (8); Bejon, P (8); Ndungu, FM (7); Nyangweso, G (5); Mwacharo, J (4); show more...; Kai, O (3); Bediako, Y (3); Ngoi, JM (3); Adams, R. (2); Manni, S (2); Farnert, A (2); Newbold, C (2); Langhorne, J (2); Recker, M (2); Osier, FHA (2); Nduati, EW (2); Valletta, JJ (2); Kimani, D (2); de Villiers, EP (2); Sanders, M (2); Lotkowska, ME (2); Sodenkamp, J (2); Lin, JW (2); Berriman, M (2); Williams, TN (2); Ogada, E (2); Olotu, A (2); Hay, SI (1); Corti, D. (1); Bianchi, S (1); Tan, J (1); Drakeley, C (1); Mwangi, T (1); Fernandez-Rodriguez, ... (1); Kamuyu, G (1); Aye, R (1); Sutton, HJ (1); Musyoki, J (1); Otieno, E (1); Cockburn, IA (1); Lanzavecchia, A (1); Geiger, R. (1); Reid, A (1); Reid, AJ (1); Addy, JWG (1); Opiyo, M (1); Liljander, A (1); Noor, AM (1); Jarrossay, D (1); show less...

University: Karolinska Institutet (9)

Language: English (9)

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