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- Kienzler, B., et al.
(författare)
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Swedish-German actinide migration experiment at ASPO hard rock laboratory
- 2003
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Ingår i: Journal of Contaminant Hydrology. - 0169-7722 .- 1873-6009. ; 61:04-jan, s. 219-233
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Tidskriftsartikel (refereegranskat)abstract
- Within the scope of a bilateral cooperation between Svensk Karnbranslehantering (SKB) and Forschungszentrum Karlsruhe, Institut fur Nukleare Entsorgung (FZK-INE), an actinide migration experiment is currently being performed at the Aspo Hard Rock Laboratory (HRL) in Sweden. This paper covers laboratory and in situ investigations on actinide migration in single-fractured granite core samples. For the in situ experiment, the CHEMLAB 2 probe developed by SKB was used. The experimental setup as well as the breakthrough of inert tracers and of the actinides Am, Np and Pu are presented. The breakthrough curves of inert tracers were analyzed to determine hydraulic properties of the fractured samples. Postmortem analyses of the solid samples were performed to characterize the flow path and the sorbed actinides. After cutting the cores, the abraded material was analyzed with respect to sorbed actinides. The slices were scanned optically to visualize the flow path. Effective volumes and inner surface areas were measured. In the experiments, only breakthrough of Np(V) was observed. In each experiment, the recovery of Np(V) was less than or equal to40%. Breakthrough of Am(III) and Pu(IV) as well as of Np(IV) was not observed.
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- Alvarsson, Jonathan, 1981-
(författare)
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Ligand-based Methods for Data Management and Modelling
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Drug discovery is a complicated and expensive process in the billion dollar range. One way of making the drug development process more efficient is better information handling, modelling and visualisation. The majority of todays drugs are small molecules, which interact with drug targets to cause an effect. Since the 1980s large amounts of compounds have been systematically tested by robots in so called high-throughput screening. Ligand-based drug discovery is based on modelling drug molecules. In the field known as Quantitative Structure–Activity Relationship (QSAR) molecules are described by molecular descriptors which are used for building mathematical models. Based on these models molecular properties can be predicted and using the molecular descriptors molecules can be compared for, e.g., similarity. Bioclipse is a workbench for the life sciences which provides ligand-based tools through a point and click interface. The aims of this thesis were to research, and develop new or improved ligand-based methods and open source software, and to work towards making these tools available for users through the Bioclipse workbench. To this end, a series of molecular signature studies was done and various Bioclipse plugins were developed.An introduction to the field is provided in the thesis summary which is followed by five research papers. Paper I describes the Bioclipse 2 software and the Bioclipse scripting language. In Paper II the laboratory information system Brunn for supporting work with dose-response studies on microtiter plates is described. In Paper III the creation of a molecular fingerprint based on the molecular signature descriptor is presented and the new fingerprints are evaluated for target prediction and found to perform on par with industrial standard commercial molecular fingerprints. In Paper IV the effect of different parameter choices when using the signature fingerprint together with support vector machines (SVM) using the radial basis function (RBF) kernel is explored and reasonable default values are found. In Paper V the performance of SVM based QSAR using large datasets with the molecular signature descriptor is studied, and a QSAR model based on 1.2 million substances is created and made available from the Bioclipse workbench.
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| 8. |
- Glimskär, A, et al.
(författare)
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Linjära landskapselement i NILS fältinventering 2003-2006
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport presenterar resultat för mängden av linjära landskapselement i olika naturtyper i det svenska landskapet. Resultaten baseras på den s.k. linjekorsningsinventeringen i fältarbetet inom det nationella miljöövervakningsprogrammet NILS (Nationell Inventering av Landskapet i Sverige). Analyserna har gjorts på uppdrag av Jordbruksverket, som underlag för bl.a. utvärderingen av miljökvalitetsmålet Ett rikt odlingslandskap. För att beskriva landskapselementens läge i landskapet har olika befintliga kartskikt använts, och dessutom en klassificering som baseras på första årets flygbildstolkning i NILS. Eftersom det är första gången en sådan markslagsklassning görs, ingår som en del att jämföra de olika underlagens användbarhet för detta syfte.Arbetet har utförts vid institutionen för skoglig resurshushållning, Sveriges lantbruksuniversitet, Umeå och institutionen för ekologi, SLU, Uppsala. NILS är ett rikstäckande miljöövervakningsprogram som följer tillstånd och förändringar i det svenska landskapet och hur dessa påverkar förutsättningarna för den biologiska mångfalden. NILS finansieras av Naturvårdsverket, där NILS ingår i programområde Landskap. Ett viktigt syfte med NILS är att följa upp de nationella miljökvalitetsmålen för olika naturtyper och fungera som underlag för att till exempel visa om genomförda miljövårdsåtgärder leder till önskade förbättringar på nationell nivå eller landsdelsnivå.
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