| 1. |
- Gu, Huaduo, et al.
(författare)
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Analysis, modeling and simulations of an innovative sliding vane rotary compressor with a rotating cylinder
- 2021
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Ingår i: Energy Conversion and Management. - : Elsevier BV. - 0196-8904. ; 230
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Tidskriftsartikel (refereegranskat)abstract
- A novel sliding vane rotary compressor with a rotating cylinder is proposed in this paper. The sliding vane dynamics analysis reveals that, compared with the traditional compressor, the friction loss at the sliding vane tips and between rotor and cylinder can be reduced to 0.25% and 10.23%. To numerically investigate the internal flow mechanism, a reliable three-dimensional simulation method is developed via Fluent 2020R1. Three pressure ratios are considered. During transient calculations, all parameters begin to fluctuate periodically after the fourth round. Both temperature and pressure for a single chamber reach the maximum near the exhaust port. As the pressure ratio εp increases from 5, 10 to 15, the outlet temperature increases from 496.9, 623.0 to 754.4 K and the mass flow rate decreases from 0.03089, 0.02946 to 0.02764 kg/s, the volumetric efficiency and isentropic compression efficiency decrease, with the maximum values of 97.14% and 90.33%. The gaps between the rotor and the cylinder and at the vane tips are 0.03 and 0.01 mm, but the leakage mass of the former is one order higher than that of the latter. The research can provide guidance for the design and practical application of sliding vane rotary compressors.
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| 2. |
- Bransford, Philip, et al.
(författare)
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ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers : An Industrial Perspective from the IQ Consortium
- 2020
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Ingår i: Molecular Pharmaceutics. - : AMER CHEMICAL SOC. - 1543-8384 .- 1543-8392. ; 17:2, s. 361-372
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Tidskriftsartikel (refereegranskat)abstract
- In October 2016, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) ICH began efforts to provide recommendations to harmonize guidances for biopharmaceutics classification system (BCS)-based biowaivers. Topics to be addressed included consideration of the dose used to classify solubility, tests, and criteria for establishing highly permeable, dissolution conditions, the influence of excipients, and aspects of product strength. The International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) is a technically focused organization of pharmaceutical and biotechnology companies with a mission of advancing science and technology to augment the capability of member companies to develop transformational solutions that benefit patients, regulators, and the broader R&D community. Its members have substantial expertise in all scientific domains associated with BCS-based waivers and drug product quality, as well as considerable experience in the application of BCS-based biowaivers. The ICH process recognizes that harmonization is achieved through the development of guidelines via a process of scientific consensus with regulatory and industry experts working side-by-side. Thus, to facilitate these efforts and to encourage open and transparent discussion of other perspectives that may exist, IQ offers their perspective on these and related topics.
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| 3. |
- Gu, Huaduo, et al.
(författare)
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Impact of discharge port configurations on the performance of sliding vane rotary compressors with a rotating cylinder
- 2021
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Ingår i: Applied Thermal Engineering. - : Elsevier BV. - 1359-4311. ; 186
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Tidskriftsartikel (refereegranskat)abstract
- With the increasing requirements of compressed gas energy storage systems for compressors and expanders, sliding vane rotary compressors are worth trying. To study the influence of different configurations of discharge ports on the performance of compressors, numerical simulations are conducted on the innovative sliding vane compressors with a rotating cylinder. The reliable Renormalization Group k-ε turbulent model is adopted in Fluent 2020R1. The results show that as the coverage angle increases, the averaged mass flow rates increase, the averaged exhaust gas temperature decreases and the leakage between the rotor and rotating cylinder and at sliding vane tips decrease. When the coverage angle increases from 15° to 45° at the central position angle of −28°, the volumetric efficiency increases from 89.38% to 92.65% while the isentropic efficiency increases from 76.43% to 86.19%. When the central position angles range from −28°, −23° to −18° at the coverage angle of 30°, the farther the discharge port is to the narrowest gap between the rotor and cylinder, the lower the outlet temperature, the less the leakage flow, and the higher the isentropic efficiency. The scheme with the central angle of −28° and coverage angle of 45° is recommended as the best one.
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| 4. |
- Hudson, Lawrence N, et al.
(författare)
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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
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Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
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Tidskriftsartikel (refereegranskat)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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| 5. |
- Polli, James E, et al.
(författare)
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Summary workshop report : bioequivalence, biopharmaceutics classification system, and beyond
- 2008
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Ingår i: AAPS Journal. - : Springer Science and Business Media LLC. - 1550-7416. ; 10:2, s. 373-379
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Tidskriftsartikel (refereegranskat)abstract
- The workshop "Bioequivalence, Biopharmaceutics Classification System, and Beyond" was held May 21-23, 2007 in North Bethesda, MD, USA. This workshop provided an opportunity for pharmaceutical scientists to discuss the FDA guidance on the Biopharmaceutics Classification System (BCS), bioequivalence of oral products, and related FDA initiatives such as the FDA Critical Path Initiative. The objective of this Summary Workshop Report is to document the main points from this workshop. Key highlights of the workshop were (a) the described granting of over a dozen BCS-based biowaivers by the FDA for Class I drugs whose formulations exhibit rapid dissolution, (b) continued scientific support for biowaivers for Class III compounds whose formulations exhibit very rapid dissolution, (c) scientific support for a number of permeability methodologies to assess BCS permeability class, (d) utilization of BCS in pharmaceutical research and development, and (e) scientific progress in in vitro dissolution methods to predict dosage form performance.
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