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| 2. |
- Sai, Hanna, et al.
(författare)
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Observations of the very young Type Ia Supernova 2019np with early-excess emission
- 2022
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 514:3, s. 3541-3558
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Tidskriftsartikel (refereegranskat)abstract
- Early-time radiative signals from Type Ia supernovae (SNe Ia) can provide important constraints on the explosion mechanism and the progenitor system. We present observations and analysis of SN 2019np, a nearby SN Ia discovered within 1–2 days after the explosion. Follow-up observations were conducted in optical, ultraviolet, and near-infrared bands, covering the phases from ∼−16.7 d to ∼+ 367.8 d relative to its B-band peak luminosity. The photometric and spectral evolutions of SN 2019np resemble the average behaviour of normal SNe Ia. The absolute B-band peak magnitude and the post-peak decline rate are Mmax(B) = −19.52 ± 0.47 mag and Δm15(B) = 1.04 ± 0.04 mag, respectively. No Hydrogen line has been detected in the nebular-phase spectra of SN 2019np. Assuming that the 56Ni powering the light curve is centrally located, we find that the bolometric light curve of SN 2019np shows a flux excess up to 5.0 per cent in the early phase compared to the radiative diffusion model. Such an extra radiation perhaps suggests the presence of an additional energy source beyond the radioactive decay of central nickel. Comparing the observed colour evolution with that predicted by different models, such as interactions of SN ejecta with circumstellar matter (CSM)/companion star, a double-detonation explosion from a sub-Chandrasekhar mass white dwarf (WD) and surface 56Ni mixing, we propose that the nickel mixing is more favoured for SN 2019np.
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| 3. |
- Lin, Weili, et al.
(författare)
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A superluminous supernova lightened by collisions with pulsational pair-instability shells
- 2023
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Ingår i: Nature Astronomy. - 2397-3366. ; 7:7, s. 779-789
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Tidskriftsartikel (refereegranskat)abstract
- Superluminous supernovae are among the most energetic stellar explosions in the Universe, but their energy sources remain an open question. Here we present long-term observations of one of the closest examples of the hydrogen-poor superluminous supernovae subclass SLSNe-I, supernova SN 2017egm, revealing the most complicated known luminosity evolution of SLSNe-I. Three distinct post-peak bumps were recorded in its light curve collected at about 100–350 days after maximum brightness, challenging current popular power models such as magnetar, fallback accretion, and interaction between ejecta and a circumstellar shell. However, the complex light curve can be well modelled by successive interactions with multiple circumstellar shells with a total mass of about 6.8–7.7 M⊙. In this scenario, large energy deposition from interaction-induced reverse shocks results in ionization of neutral oxygen in the supernova ejecta and hence a much lower nebular-phase line ratio of [O I] λ6,300/([Ca II] + [O II]) λ7,300 (~0.2) compared with that derived for other superluminous and normal stripped-envelope supernovae. The pre-existing multiple shells indicate that the progenitor of SN 2017egm experienced pulsational mass ejections triggered by pair instability within 2 years before explosion, in robust agreement with theoretical predictions for a pre-pulsation helium-core mass of 48–51 M⊙.
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| 4. |
- Chi, Kim N., et al.
(författare)
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Apalutamide in Patients With Metastatic Castration-Sensitive Prostate Cancer : Final Survival Analysis of the Randomized, Double-Blind, Phase III TITAN Study
- 2021
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Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 0732-183X. ; 39:20, s. 2294-2303
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The first interim analysis of the phase III, randomized, placebo-controlled TITAN study showed that apalutamide significantly improved overall survival (OS) and radiographic progression-free survival in patients with metastatic castration-sensitive prostate cancer (mCSPC) receiving ongoing androgen deprivation therapy (ADT). Herein, we report final efficacy and safety results after unblinding and placebo-to-apalutamide crossover. METHODS: Patients with mCSPC (N = 1,052) were randomly assigned 1:1 to receive apalutamide (240 mg QD) or placebo plus ADT. After unblinding in January 2019, placebo-treated patients were allowed to receive apalutamide. Efficacy end points were updated using the Kaplan-Meier method and Cox proportional-hazards model without formal statistical retesting and adjustment for multiplicity. Change from baseline in Functional Assessment of Cancer Therapy-Prostate total score was assessed. RESULTS: With a median follow-up of 44.0 months, 405 OS events had occurred and 208 placebo-treated patients (39.5%) had crossed over to apalutamide. The median treatment duration was 39.3 (apalutamide), 20.2 (placebo), and 15.4 months (crossover). Compared with placebo, apalutamide plus ADT significantly reduced the risk of death by 35% (median OS not reached v 52.2 months; hazard ratio, 0.65; 95% CI, 0.53 to 0.79; P < .0001) and by 48% after adjustment for crossover (hazard ratio, 0.52; 95% CI, 0.42 to 0.64; P < .0001). Apalutamide plus ADT delayed second progression-free survival and castration resistance (P < .0001 for both). Health-related quality of life, per total Functional Assessment of Cancer Therapy-Prostate, in both groups was maintained through the study. Safety was consistent with previous reports. CONCLUSION: The final analysis of TITAN confirmed that, despite crossover, apalutamide plus ADT improved OS, delayed castration resistance, maintained health-related quality of life, and had a consistent safety profile in a broad population of patients with mCSPC.
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| 5. |
- Khan, Tauseef A., et al.
(författare)
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Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke : Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals
- 2013
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 42:2, s. 475-492
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Tidskriftsartikel (refereegranskat)abstract
- Background At the APOE gene, encoding apolipoprotein E, genotypes of the epsilon 2/epsilon 3/epsilon 4 alleles associated with higher LDL-cholesterol (LDL-C) levels are also associated with higher coronary risk. However, the association of APOE genotype with other cardiovascular biomarkers and risk of ischaemic stroke is less clear. We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or other lipids and biomarkers of cardiovascular risk. Methods We conducted a systematic review of published and unpublished studies reporting on APOE genotype and ischaemic stroke. We pooled 41 studies (with a total of 9027 cases and 61 730 controls) using a Bayesian meta-analysis to calculate the odds ratios (ORs) for ischaemic stroke with APOE genotype. To better evaluate potential mechanisms for any observed effect, we also conducted a pooled analysis of primary data using 16 studies (up to 60 883 individuals) of European ancestry. We evaluated the association of APOE genotype with lipids, other circulating biomarkers of cardiovascular risk and carotid intima-media thickness (C-IMT). Results The ORs for association of APOE genotypes with ischaemic stroke were: 1.09 (95% credible intervals (CrI): 0.84-1.43) for epsilon 2/epsilon 2; 0.85 (95% CrI: 0.78-0.92) for epsilon 2/epsilon 3; 1.05 (95% CrI: 0.89-1.24) for epsilon 2/epsilon 4; 1.05 (95% CrI: 0.99-1.12) for epsilon 3/epsilon 4; and 1.12 (95% CrI: 0.94-1.33) for epsilon 4/epsilon 4 using the epsilon 3/epsilon 3 genotype as the reference group. A regression analysis that investigated the effect of LDL-C (using APOE as the instrument) on ischaemic stroke showed a positive dose-response association with an OR of 1.33 (95% CrI: 1.17, 1.52) per 1 mmol/l increase in LDL-C. In the separate pooled analysis, APOE genotype was linearly and positively associated with levels of LDL-C (P-trend: 2 x 10(-152)), apolipoprotein B (P-trend: 8.7 x 10(-06)) and C-IMT (P-trend: 0.001), and negatively and linearly associated with apolipoprotein E (P-trend: 6 x 10(-26)) and HDL-C (P-trend: 1.6 x 10(-12)). Associations with lipoprotein(a), C-reactive protein and triglycerides were non-linear. Conclusions In people of European ancestry, APOE genotype showed a positive dose-response association with LDL-C, C-IMT and ischaemic stroke. However, the association of APOE epsilon 2/epsilon 2 genotype with ischaemic stroke requires further investigation. This cross-domain concordance supports a causal role of LDL-C on ischaemic stroke.
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| 6. |
- Lin, Jing, et al.
(författare)
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Association of time spent in outdoor light and genetic susceptibility with the risk of type 2 diabetes
- 2023
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Ingår i: Science of the Total Environment. - 0048-9697 .- 1879-1026. ; 888
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Tidskriftsartikel (refereegranskat)abstract
- To explore the joint association of time spent in outdoor light and genetic susceptibility with the risk of type 2 diabetes (T2D). A total of 395,809 individuals of European ancestry with diabetes-free at baseline in the UK Biobank were in-cluded. Time spent in outdoor light on a typical day in summer or winter was obtained from the questionnaire. T2D genetic risk was quantified via the polygenic risk score (PRS) and divided into three levels based on tertiles (lower, in-termediate, and higher). T2D cases were ascertained according to the hospital records of diagnoses. After the median follow-up of 12.55 years, the association of outdoor light time and T2D risk demonstrated a nonlinear (J-shaped) trend. Compared to individuals with an average of 1.5-2.5 h/day of outdoor light, individuals who spent <1.5 h/ day or >2.5 h/day in outdoor light both had an elevated risk of T2D, and the risk of T2D related to <1.5 h/day outdoor light time was much higher (hazard ratio [HR] = 1.10, 95 % confidence interval [CI]: 1.06 to 1.15). After combining with PRS, in comparison with the lower PRS - average 1.5-2.5 h/day outdoor light group (reference), the higher PRS - <1.5 h/day outdoor light group had the highest T2D risk (HR = 2.74, 95 % CI: 2.55 to 2.94), the higher PRS - >2.5 h/ day outdoor light group also had a higher risk of T2D (HR = 2.58, 95 % CI: 2.43 to 2.74). The interaction between average outdoor light time and genetic susceptibility for T2D was statistically significant (Paverage for interaction <0.001). We found that optimal outdoor light time may modify the genetic risk for T2D. This suggests the T2D risk related to genetic factors could be prevented by spending optimal outdoor light time.
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| 7. |
- Sheng, Weili, et al.
(författare)
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Design matters: New insights on optimizing energy consumption for residential buildings
- 2021
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Ingår i: Energy and Buildings. - : Elsevier BV. - 0378-7788. ; 242
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we construct a unique database for 1228 residential buildings in Hong Kong to investigate how the spatial features of these residential buildings affect the electricity consumption in the communal area. We choose Hong Kong for this analysis as the city owns a large number of standard-type residential buildings managed by the public institution, which could be affected strongly by environmental policies. Both the machine learning method, based on the Least Absolute Shrinkage and Selection Operator (LASSO), and econometric regressions are adopted to analyse the data. We first utilize the machine learning LASSO technique to identify the most relevant factors for the subsequent econometric analysis. Our results show that the electricity demand for relatively low consumption building types, such as Twin Tower, is 6% lower than that of the high consumption building types. Newly constructed buildings usually belong to the medium consumption types, with the estimated monthly electricity consumption per apartment in communal areas to be around 50.2 kWh on average in 2020. These findings shed light on the nexus between spatial features and energy use for complex buildings, potentially contributing to the better crafting of energy-saving policy and the improvement of residential building programmes.
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| 8. |
- Wang, Shuqi, et al.
(författare)
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Association of lifespan reproductive duration with depression in Swedish twins : The role of hormone replacement therapy
- 2023
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Ingår i: International Journal of Gynecology & Obstetrics. - : Wiley. - 0020-7292 .- 1879-3479. ; 162:1, s. 309-316
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To examine the association between reproductive duration and postmenopausal depression (taking the use of hormone replacement therapy [HRT] into account).Methods: In this population-based cohort study, 11 320 postmenopausal women (mean age 63.6 years) were followed for up to 18 years. Reproductive duration was categorized into three groups: short (≤34 years), average (35–39 years), and long (≥40 years). Depression was ascertained from the Sweden National Patient Registry.Results: During the follow up, 593 (5.24%) women developed depression. In the multi-adjusted generalized estimating equation model, the odds ratios (ORs) of depression were 1.28 (95% confidence interval [CI] 1.05–1.55) and 1.25 (95% CI 1.01–1.55) for women with short and long reproductive durations, respectively, compared with those women with average reproductive duration. Women with a non-typical reproductive duration (≤34 or ≥40 years) who received HRT were at a higher risk of depression (OR 1.82, 95% CI 1.42–2.33). There was a significant additive interaction between non-typical reproductive duration and the use of HRT on depression (attributable proportion 0.26, 95% CI 0.03–0.50).Conclusion: Women with a short or long reproductive duration, especially those with a history of HRT use, have a higher risk of depression after menopause compared with those with an average reproductive duration.
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| 9. |
- Wang, Sifan, et al.
(författare)
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Fire carbon emissions over Equatorial Asia reduced by shortened dry seasons
- 2023
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Ingår i: npj Climate and Atmospheric Science. - 2397-3722. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- Fire carbon emissions over Equatorial Asia (EQAS) play a critical role in the global carbon cycle. Most regional fire emissions (89.0%) occur in the dry season, but how changes in the dry-season length affect the fire emissions remains poorly understood. Here we show that, the length of the EQAS dry season has decreased significantly during 1979–2021, and the delayed dry season onset (5.4 ± 1.6 (± one standard error) days decade−1) due to increased precipitation (36.4 ± 9.1 mm decade−1) in the early dry season is the main reason. The dry season length is strongly correlated with the length of the fire season. Increased precipitation during the early dry season led to a significant reduction (May: −0.7 ± 0.4 Tg C decade−1; August: −12.9 ± 6.7 Tg C decade−1) in fire carbon emissions during the early and peak fire season. Climate models from the Coupled Model Intercomparison Project Phase 6 project a continued decline in future dry season length in EQAS under medium and high-emission scenarios, implying further reductions in fire carbon emissions.
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| 10. |
- Xu, Weili, et al.
(författare)
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Prevalence of Overweight and Obesity among Chinese Adults : Role of Adiposity Indicators and Age
- 2016
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Ingår i: Obesity Facts. - : S. Karger AG. - 1662-4025 .- 1662-4033. ; 9:1, s. 17-28
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The role of different body fat indicators and age in assessing the prevalence of obesity is unclear. We aimed to examine to what extent different body fat indicators including BMI, waist circumference (WC) and waist-to-hip ratio (WHR) affect the prevalence of overweight and obesity among Chinese adults taking age into account. Methods: This population-based cross-sectional study included a random sample of 7,603 adults aged 20-79 years across entire Tianjin, China. BMI, WC, and WHR were used to define overweight and obesity following standard criteria. Prevalence rates were calculated and standardized using local age-and gender-specific census data. Logistic regression was used in data analysis. Results: Using the combination of BMI, WC, and WHR, the prevalence of overweight and obesity was 69.8%, and increased with age till the age of 60 and a decline thereafter. The prevalence of overweight assessed by BMI was higher than that assessed by WC and WHR, while the prevalence of obesity defined by BMI was much lower than that defined by WC or WHR. Conclusion: The prevalence of overweight and obesity is about 70% among Chinese adults. Adiposity indicators and age play an important role in the prevalence of overweight and obesity.
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