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- Sloot, Frea, et al.
(författare)
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Inventory of current EU paediatric vision and hearing screening programmes
- 2015
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Ingår i: Journal of Medical Screening. - : SAGE Publications. - 0969-1413 .- 1475-5793. ; 22:2, s. 55-64
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To examine the diversity in paediatric vision and hearing screening programmes in Europe. Methods: Themes for comparison of screening programmes derived from literature were used to compile three questionnaires on vision, hearing, and public health screening. Tests used, professions involved, age, and frequency of testing seem to influence sensitivity, specificity, and costs most. Questionnaires were sent to ophthalmologists, orthoptists, otolaryngologists, and audiologists involved in paediatric screening in all EU full-member, candidate, and associate states. Answers were cross-checked. Results: Thirty-nine countries participated; 35 have a vision screening programme, 33 a nation-wide neonatal hearing screening programme. Visual acuity (VA) is measured in 35 countries, in 71% of these more than once. First measurement of VA varies from three to seven years of age, but is usually before age five. At age three and four, picture charts, including Lea Hyvarinen, are used most; in children over four, Tumbling-E and Snellen. As first hearing screening test, otoacoustic emission is used most in healthy neonates, and auditory brainstem response in premature newborns. The majority of hearing testing programmes are staged; children are referred after 1–4 abnormal tests. Vision screening is performed mostly by paediatricians, ophthalmologists, or nurses. Funding is mostly by health insurance or state. Coverage was reported as >95% in half of countries, but reporting was often not first-hand. Conclusion: Largest differences were found in VA charts used (12), professions involved in vision screening (10), number of hearing screening tests before referral (1–4), and funding sources (8).
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| 4. |
- Peters, Gregory, 1970, et al.
(författare)
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Improving odour assessment in LCA - the odour footprint
- 2014
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Ingår i: International Journal of Life Cycle Assessment. - : Springer Science and Business Media LLC. - 1614-7502 .- 0948-3349. ; 19:11, s. 1891-1900
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Odour is an important aspect of systems for humanand agricultural waste management and many technologiesare developed with the sole purpose of reducing odour.Compared with greenhouse gas assessment and the assessmentof toxicity, odour assessment has received little attentionin the life cycle assessment (LCA) community. This articleaims to redress this.Methods Firstly, a framework for the assessment of odourimpacts in LCA was developed considering the classicalLCA framework of emissions, midpoint and endpoint indicators.This suggested that an odour footprint midpoint indicatorwas worth striving for. An approach to calculating an arealindicator we call “odour footprint”, which considers the odourdetection threshold, the diffusion rate and the kinetics ofdegradation of odourants, was implemented in MATLAB.We demonstrated the use of the characterisation factors wecalculated in a case study based on odour removal technologyapplied to a pig barn.Results and discussion We produced a list of 33 linear characterisation factors based on hydrogen sulphide equivalents, analogous to the linear carbon dioxide equivalency factors in use in carbon footprinting, or the dichlorobenzene equivalency factors developed for assessment of toxic impacts in LCA. Like the latter, this odour footprint method does not take local populations and exposure pathway analysis into account—its intent is not to assess regulatory compliance or detailed design. The case study showed that despite the need for materials and energy, large factor reductions in odour footprint andeutrophication potential were achieved at the cost of a smaller factor increase in greenhouse emissions.Conclusions The odour footprint method is proposed as animprovement on the established midpoint method for odourassessment in LCA. Unlike it, the method presented hereconsiders the persistence of odourants. Over time, we hopeto increase the number of characterised odourants, enablinganalysts to perform simple site-generic LCA on systems withodourant emissions.
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| 5. |
- Riegman, PHJ, et al.
(författare)
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Optimizing sharing of hospital biobank samples
- 2015
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Ingår i: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 7:297, s. 297fs31-
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Tidskriftsartikel (refereegranskat)abstract
- Implementing technical guidelines and standards as well as ways to boost cooperation should facilitate sharing of hospital biobank samples.
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| 6. |
- ten Hoeve, Arne L., MSc, et al.
(författare)
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The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages
- 2022
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Ingår i: Cell Host and Microbe. - : Elsevier BV. - 1931-3128 .- 1934-6069. ; 30:11, s. 1570-1588.e7
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Tidskriftsartikel (refereegranskat)abstract
- Upon pathogen detection, macrophages normally stay sessile in tissues while dendritic cells (DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan Toxoplasma gondii exploits the trafficking of mononuclear phagocytes for dissemination via unclear mechanisms. We report that, upon T. gondii infection, macrophages initiate the expression of transcription factors normally attributed to DCs, upregulate CCR7 expression with a chemotactic response, and perform systemic migration when adoptively transferred into mice. We show that parasite effector GRA28, released by the MYR1 secretory pathway, cooperates with host chromatin remodelers in the host cell nucleus to drive the chemotactic migration of parasitized macrophages. During in vivo challenge studies, bone marrow-derived macrophages infected with wild-type T. gondii outcompeted those challenged with MYR1- or GRA28-deficient strains in migrating and reaching secondary organs. This work reveals how an intracellular parasite hijacks chemotaxis in phagocytes and highlights a remarkable migratory plasticity in differentiated cells of the mononuclear phagocyte system.
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