| 1. |
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| 2. |
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1897 : Mediehistorier kring Stockholmsutställningen
- 2006
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- När börjar mediehistorien? Mediehistoria var länge liktydigt med historien om 1900-talets massmedier press, radio, teve och film. I den här boken skildras istället ett äldre medielandskap. Med utgångspunkt i Stockholmsutställningen 1897 beskriver författarna det utbud av gamla och nya medier som samlades på utställningen, från äldre attraktioner som camera obscura, dioramor och vaxfigurer till spektakulära nyheter som fonograf, kinematograf och röntgenbilder. Boken ger inblickar i några av det sena 1800-talets ledande medieindustrier, och diskuterar bland annat frågor om mediekonsumtion, publikpositioner och historiska medieringsvillkor. De medietekniker som presenterades på Stockholmsutställningen 1897 lagrade på samma gång utställningen för framtiden. Ett centralt tema är därför hur dessa medieringar blivit identiska med minnet av utställningen, och hur detta arkiv organiserats utifrån mediernas specifika egenskaper. På den DVD-skiva som medföljer boken har ett nytt mediearkiv skapats över Stockholmsutställningen 1897 och dess många länkar till en bredare mediekultur.
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| 3. |
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1973. En träff med tidsandan
- 2008
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Ingår i: 1973. En träff med tidsandan. - Lund : Nordic Academic Press. - 9789189116979 ; , s. 11-21
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)
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| 4. |
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| 6. |
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24th Anniversary World Congress on Biosensors – Biosensors 2014
- 2014
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Proceedings (redaktörskap) (refereegranskat)abstract
- Welcome to Biosensors 2014 and welcome to Melbourne, ranked as the world's most liveable city!This is the 24th anniversary edition of the World Congress on Biosensors and we continue to evolve, adapt and grow into new roles to serve the analytical needs of a rapidly changing society. Advances in telecommunications, expert systems and distributed diagnostics are prompting us to question the conventional ways we deliver healthcare, while robust industrial sensors are facilitating new paradigms in R&D and production. Personalisation of everything from medicine to environmental control, is giving new impetus to consumer choice and ownership of information, and will inevitably generate new payment structures and business models. Moreover, a deeper understanding of the bio/electronic interface leads us towards new horizons in areas such as bionics, power generation and computing. Wearable, mobile and integrated sensors are becoming common place, but most current products have taken the easy path of incorporating physical sensors for parameters such as temperature, pressure, orientation or position. There is still a glaring absence of suitably robust and convenient commercial biosensors for body chemistries and ecosystems, and therein lies the real opportunities for progress. We are a still-emerging technology that is fuelling scientific discovery and underpinning new products to enhance the length and quality of life.Always in a new country and always with fresh plenary speakers, we aim to reflect the latest and the best in Biosensors. This three-day event, organised by Elsevier in association with Biosensors & Bioelectronics, consists of two daily plenary presentations from leading figures in the field, followed by four parallel sessions, comprising a rigorously refereed selection of submitted papers. This year, we received 1,156 submissions of which 124 with be presented as regular Oral papers, with an additional 20 singled out as Invited talks and a further 12 selected for extended Keynote talks. The Keynote speakers have also been invited to submit full papers for consideration for the Biosensors and Bioelectronics Prize for the most original contribution to the Congress and the winners will be announced at the conference banquet on Thursday night. There will also be poster awards and you will find voting slips for each of the three days in your delegate bags. The winners of these awards and a prize draw, sponsored by Linköping University and Acreo Swedish ICT, will be announced at the closing ceremony on Friday. In order to enhance the valued medium of poster presentation, this year we have introduced a new Poster in my Pocket Ap. Poster presenters have been able to upload a PDF of their poster prior to the conference to help increase the exposure of their work. This compliments the other new Ap introduced this year to place the full programme at your fingertips. Selected oral presentations will also have the opportunity to upload their talks online for future viewing.The academic programme, as usual, is enhanced by a fine collection of commercial exhibits and in addition to browsing their stands; you will be able to hear short elevator pitches during the breaks. We must thank our main commercial sponsor, Ercon for their generous and continued support of our congress. Thanks also to New Tools for Health for sponsoring the pre-congress Networking Event. Now a regular feature for Biosensors, we have a pre-congress school, this year on Optical Biosensors, which is brought to you by Profs Fran Ligler and Tanya Monro. Last, but not least I must thank our marvellous Local Organising Committee chaired by Prof Justin Gooding, our hard working main Organising Committee, all the speakers and delegates, and the Elsevier team for all their support.Our delegates come from the four corners of the globe to hear the science, to grasp the opportunities and to meet the people; it’s going to be the best meeting yet. Enjoy and don’t forget to join us again in Gothenburg, Sweden, 24-27 May for Biosensor 2016!
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| 7. |
- A. Almaqtari, Faozi, et al.
(författare)
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Earning management estimation and prediction using machine learning: A systematic review of processing methods and synthesis for future research
- 2022
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Ingår i: 2021 International Conference on Technological Advancements and Innovations (ICTAI). - : IEEE.
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Konferensbidrag (refereegranskat)abstract
- The present study highlights earning management optimization possibilities to constrain the events of earning management and financial fraud. Our study investigates the existing stock of knowledge and strand literature available on earning management and fraud detection. It aims to review systematically the methods and techniques used by prior research to determine earning management and fraud detection. The results indicate that prior research in earning management optimization is diverged among several techniques and none of these techniques has provided an ideal optimization for earning management. Further, the results reveal that earning management determinants are complex based on the type and size of business entities which complicate the optimization possibilities. The current research brings useful insights for predicting and optimization of earnings management and financial fraud. The present study has significant implications for policymakers, stock markets, auditors, investors, analysts, and professionals.
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| 8. |
- A Atlasov, Kirill, et al.
(författare)
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1D photonic band formation and photon localization in finite-size photonic-crystal waveguides
- 2010
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Ingår i: OPTICS EXPRESS. - 1094-4087. ; 18:1, s. 117-122
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Tidskriftsartikel (refereegranskat)abstract
- A transition from discrete optical modes to 1D photonic bands is experimentally observed and numerically studied in planar photonic-crystal (PhC) L-N microcavities of length N. For increasing N the confined modes progressively acquire a well-defined momentum, eventually reconstructing the band dispersion of the corresponding waveguide. Furthermore, photon localization due to disorder is observed experimentally in the membrane PhCs using spatially resolved photoluminescence spectroscopy. Implications on single-photon sources and transfer lines based on quasi-1D PhC structures are discussed.
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| 9. |
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| 10. |
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| 11. |
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A feminist companion to the posthumanities
- 2018
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- This companion is a cutting-edge primer to critical forms of the posthumanities and the feminist posthumanities, aimed at students and researchers who want to catch up with the recent theoretical developments in various fields in the humanities, such as new media studies, gender studies, cultural studies, science and technology studies, human animal studies, postcolonial critique, philosophy and environmental humanities. It contains a collection of nineteen new and original short chapters introducing influential concepts, ideas and approaches that have shaped and developed new materialism, inhuman theory, critical posthumanism, feminist materialism, and posthuman philosophy. A resource for students and teachers, this comprehensive volume brings together established international scholars and emerging theorists, for timely and astute definitions of a moving target – posthuman humanities and feminist posthumanities.
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| 12. |
- A Herrera, I, et al.
(författare)
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Comparing a multi-linear (STEP) and systemic (FRAM) method for accident analysis
- 2010
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Ingår i: RELIABILITY ENGINEERING and SYSTEM SAFETY. - London, UK : Elsevier Science B.V., Amsterdam.. - 0951-8320. ; 95:12, s. 1269-1275, s. 19-26
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Tidskriftsartikel (refereegranskat)abstract
- Accident models and analysis methods affect what accident investigators look for, which contributory factors are found, and which recommendations are issued. This paper contrasts the Sequentially Timed Events Plotting (STEP) method and the Functional Resonance Analysis Method (FRAM) for accident analysis and modelling. The main issue addressed in this paper is the comparison of the established multi-linear method STEP with the new systemic method FRAM and which new insights the latter provides for accident analysis in comparison to the former established multi-linear method. Since STEP and FRAM are based on a different understandings of the nature of accidents, the comparison of the methods focuses on what we can learn from both methods, how, when, and why to apply them. The main finding is that STEP helps to illustrate what happened, involving which actors at what time, whereas FRAM illustrates the dynamic interactions within socio-technical systems and lets the analyst understand the how and why by describing non-linear dependencies, performance conditions, variability, and their resonance across functions.
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| 13. |
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A History of the Surrealist Novel
- 2023. - 1
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- A History of the Surrealist Novel offers a rich, long, and elastic historiography of the surrealist novel, taking into consideration an abundance of texts previously left out of critical accounts. Its twenty thematically organized chapters examine surrealist prose texts written in French, English, Spanish, German, Greek, and Japanese, from the emergence of the surrealist movement in the 1920s and 1930s, through the post-war and postmodern periods, and up to the contemporary moment. This approach extends received narratives regarding surrealism's geographical locations and considers its transnational movement and modes of circulation. Moreover, it challenges critical biases that have defined surrealism in predominantly masculine terms, and which tie the movement to the interwar or early post-war years. This book will appeal both to scholars and students of surrealism and its legacies, modernist literature, and the history of the novel.
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| 14. |
- A Hulten, Maj, et al.
(författare)
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On the origin of the maternal age effect in trisomy 21 Down syndrome: the Oocyte Mosaicism Selection model
- 2010
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Ingår i: Reproduction. - 1470-1626 .- 1476-3990. ; 139:1, s. 1-9
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Forskningsöversikt (refereegranskat)abstract
- We have recently documented that trisomy 21 mosaicism is common in human foetal ovaries. On the basis of this observation we propose that the maternal age effect in Down syndrome (DS) is caused by the differential behaviour of trisomy 21 in relation to disomy 21 oocytes during development from foetal life until ovulation in adulthood. in particular, we suggest that trisomy 21 oocytes, lagging behind those that are disomic, may escape the timed pruning of the seven million in foetal life to the 300-400 finally selected for ovulation. The net effect of this preferential elimination will be an accumulation of trisomy 21 oocytes in the ovarian reserve of older women. We here highlight the implications of this Oocyte Mosaicism Selection (OMS) model with respect to the prevalent view that the maternal age effect is complex, dependent on many different biological and environmental factors. We examine conclusions drawn from recent large-scale studies in families, tracing DNA markers along the length of chromosome 21q between parents and DS children, in comparison to the OMS model. We conclude that these family linkage data are equally compatible with the maternal age effect originating from the accumulation of trisomy 21 oocytes with advancing maternal age. One relatively straightforward way to get to grips with what is actually going on in this regard would be to compare incidence of trisomy 21 oocytes (and their pairing configurations) in foetal ovaries with that in oocytes at the meiosis I stage from adult women.
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| 15. |
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| 16. |
- A.S.M. Monjurul, Hasan, et al.
(författare)
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Biogas potential from municipal and agricultural residual biomass for power generation in Hazaribagh, Bangladesh : A strategy to improve the energy system
- 2019
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Ingår i: Renewable Energy Focus. - : Elsevier BV. - 1755-0084. ; 29:June 2019, s. 14-23
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Tidskriftsartikel (refereegranskat)abstract
- Energy is considered as one of the significant benchmarks towards sustainable growth. Due to the recenteconomic growth, energy demand is increasing day by day in Bangladesh. The power generation mainlyrelies on fossil fuels though there are plans to increase the renewable energy share by the concernstakeholders. Considering the global warming, energy generation from renewable sources is consideredas a sustainable way to mitigate the anthropogenic emission. This study, therefore, addresses thepotentiality of biogas production from municipal waste and agricultural residues in a city territory ofDhaka namely Hazaribagh. The potential sources include wastes from two markets, six slaughterhouses,domestic wastes, one poultry farm and three croplands. The calculations made in this study to estimatethe amount of biogas and electricity from the described sources are done in a simple way, just to illustratethe potential. This study suggests that there is a good potentiality of biogas production and electricitygeneration from municipal wastes and agricultural residues of Hazaribagh. Moreover, this study alsomentions the significant actors like government, future owners, people and so on that are needed to beincorporated to implement biogas solution in a city territory.
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| 17. |
- A. Strumpfer, Johan, et al.
(författare)
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Stretching of Twitchin Kinase
- 2012
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Ingår i: Biophysical Journal. - St. Louis, MO, United States : Cell Press. - 0006-3495 .- 1542-0086. ; 102:3 Supplement 1, s. 361a-362a
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Tidskriftsartikel (refereegranskat)abstract
- The giant proteins from the titin family, that form cytoskeletal filaments, have emerged as key mechanotransducers in the sarcomere. These proteins contain a conserved kinase region, which is auto-inhibited by a C-terminal tail domain. The inhibitory tail domain occludes the active sites of the kinases, thus preventing ATP from binding. It was proposed that through application of a force, such as that arising during muscle contraction, the inhibitory tail becomes detached, lifting inhibition. The force-sensing ability of titin kinase was demonstrated in AFM experiments and simulations [Puchner, et al., 2008, PNAS:105, 13385], which showed indeed that mechanical forces can remove the autoinhibitory tail of titin kinase. We report here steered molecular dynamics simulations (SMD) of the very recently resolved crystal structure of twitchin kinase, containing the kinase region and flanking fibronectin and immuniglobulin domains, that show a variant mechanism. Despite the significant structural and sequence similarity to titin kinase, the autoinhibitory tail of twitchin kinase remains in place upon stretching, while the N-terminal lobe of the kinase unfolds. The SMD simulations also show that the detachment and stretching of the linker between fibronectin and kinase regions, and the partial extension of the autoinhibitory tail, are the primary force-response. We postulate that this stretched state, where all structural elements are still intact, may represent the physiologically active state.
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| 18. |
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| 19. |
- Aaboen, Lise
(författare)
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BATON-CHANGING ON EGGSHELLS – TRANSFERRING SUPPLIER RELATIONSHIPS WHEN MOVING PRODUCTION
- 2014
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Konferensbidrag (refereegranskat)abstract
- Production transfers are a result of outsourcing and offshoring decisions. Though, because ofthe strategic focus of the outsourcing literature have not the operational issues of howrelationship development between sender, receiver and raw material been fully depicted. Thepurpose of the present paper is to explore relationship development connected to transfer ofraw material supplies responsibility during transfer of production. To fulfil the purpose, fourdifferent production transfers were studied: three from Sweden to China, Romania andHungary respectively and one transfer from Holland to Sweden. We can see that thedependence and power shifts gradually between the sender and the receiver and therelationship between them sets the arena for what relationship is developed between thereceiver and the raw material suppliers. Furthermore, short social distances can over bridgecultural and technological distances to some extent, because it motivates to take therelationship into a more developed state.
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| 20. |
- Aaboen, Lise, et al.
(författare)
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Case-based entrepreneurship education in and for the Nordic region
- 2022
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Ingår i: Reframing the Case Method in Entrepreneurship Education.. - : Edward Elgar Publishing. - 9781800881143 - 9781800881150 ; , s. 2-17
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Bokkapitel (refereegranskat)abstract
- The case method provides entrepreneurship educators with great potential to be entrepreneurial and to think outside the box when adjusting the case method for increased entrepreneurial learning. This chapter provides the theoretical background of case-based entrepreneurship education and a debate on context in case teaching in general and the Nordic countries in particular. Further the chapter provides a synopsis and reflections of how the chapters in this book discuss the design and utilization of cases through 2 parts. Part 1 includes theoretical perspectives, discussions, and practical procedures on how the case method and case activities can be reframed and approached in entrepreneurship education in general and for experiential learning in particular. Part 2 contributes with a collection of Nordic entrepreneurship cases with accompanying teaching notes. We believe that this book is of great inspiration for entrepreneurship educators wanting to use the case method in their teaching.
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| 21. |
- Aaboen, Lise, et al.
(författare)
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The relationship development aspect of production transfer
- 2016
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Ingår i: Journal of Purchasing and Supply Management. - : Pergamon Press. - 1478-4092 .- 1873-6505. ; 22:1, s. 53-65
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Tidskriftsartikel (refereegranskat)abstract
- Production transfers are a result of outsourcing and offshoring decisions. Because of the strategic focus of the outsourcing literature, the operational issues of relationship development between sender and receiver and its impact on the transfer progress have not been fully depicted. The purpose of the present paper is to explore relationship development during production transfer. To fulfil this purpose, we studied three different production transfers and derived four propositions for further testing. Our main conclusions included that dependence and power gradually shift between the sender and the receiver and that the relationship between them sets the arena for what types of relationships can be developed between the receiver and the suppliers. Furthermore, short social distances can bridge cultural and technological distances to some extent, because it motivates the actors to bring their relationship into a more developed state. Finally, we noticed that the headquarters’ involvement can work both as an inhibitor as well as a converter.
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| 22. |
- Aafjes-van Doorn, Katie, et al.
(författare)
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Patients’ Affective Processes Within Initial Experiential Dynamic Therapy Sessions
- 2017
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Ingår i: Psychotherapy. - : American Psychological Association (APA). - 0033-3204 .- 1939-1536. ; 54:2, s. 175-183
-
Tidskriftsartikel (refereegranskat)abstract
- Research has indicated that patients’ in-session experience of previously avoided affects may be important for effective psychotherapy. The aim of this study was to investigate patients’ in-session levels of affect experiencing in relation to their corresponding levels of insight, motivation, and inhibitory affects in initial Experiential Dynamic Therapy (EDT) sessions. Four hundred sixty-six 10-min video segments from 31 initial sessions were rated using the Achievement of Therapeutic Objectives Scale. A series of multilevel growth models, controlling for between-therapist variability, were estimated to predict patients’ adaptive affect experiencing (Activating Affects) across session segments. In line with our expectations, higher within-person levels of Insight and Motivation related to higher levels of Activating Affects per segment. Contrary to expectations, however, lower levels of Inhibition were not associated with higher levels of Activating Affects. Further, using a time-lagged model, we did not find that the levels of Insight, Motivation, or Inhibition during one session segment predicted Activating Affects in the next, possibly indicating that 10-min segments may be suboptimal for testing temporal relationships in affective processes. Our results suggest that, to intensify patients’ immediate affect experiencing in initial EDT sessions, therapists should focus on increasing insight into defensive patterns and, in particular, motivation to give them up. Future research should examine the impact of specific inhibitory affects more closely, as well as between-therapist variability in patients’ in-session adaptive affect experiencing.
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| 23. |
- Aagaard, Knut E., et al.
(författare)
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Factors associated with healing failure after early repair of acute, trauma-related rotator cuff tears
- 2023
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Ingår i: Journal of Shoulder and Elbow Surgery. - : MOSBY-ELSEVIER. - 1058-2746 .- 1532-6500. ; 32:10, s. 2074-2081
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Tidskriftsartikel (refereegranskat)abstract
- Background: Healing failure after rotator cuff repair is a challenging problem. Acute, trauma-related tears are considered a separate entity and are often treated surgically. The aim of this study was to identify factors associated with healing failure in previously asymptomatic patients with trauma-related rotator cuff tears treated with early arthroscopic repair. Methods: This study included 62 consecutively recruited patients (23% women; median age, 61 years; age range, 42-75 years) with acute symptoms in a previously asymptomatic shoulder and a magnetic resonance imaging–verified full-thickness rotator cuff tear after shoulder trauma. All patients were offered, and underwent, early arthroscopic repair, during which a biopsy specimen was harvested from the supraspinatus tendon and analyzed for signs of degeneration. Of the patients, 57 (92%) completed 1-year follow-up and underwent assessment of repair integrity on magnetic resonance images according to the Sugaya classification. Risk factors for healing failure were investigated using a causal-relation diagram where age, body mass index, tendon degeneration (Bonar score), diabetes mellitus, fatty infiltration (FI), sex, smoking, tear location regarding integrity of the rotator cable, and tear size (number of ruptured tendons and tendon retraction) were included and analyzed. Results: Healing failure at 1 year was identified in 37% of patients (n = 21). A high degree of FI of the supraspinatus muscle (P = .01), a tear location including disruption of rotator cable integrity (P = .01), and old age (P = .03) were associated with healing failure. Tendon degeneration as determined by histopathology was not associated with healing failure at 1-year follow-up (P = .63). Conclusion: Older age, increased FI of the supraspinatus muscle, and a tear including disruption of the rotator cable increased the risk of healing failure after early arthroscopic repair in patients with trauma-related full-thickness rotator cuff tears.
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| 24. |
- Aagaard, Knut E., et al.
(författare)
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No differences in histopathological degenerative changes found in acute, trauma-related rotator cuff tears compared with chronic, nontraumatic tears
- 2022
-
Ingår i: Knee Surgery, Sports Traumatology, Arthroscopy. - : Springer Science and Business Media LLC. - 0942-2056 .- 1433-7347. ; 30:7, s. 2521-2527
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Acute trauma-related rotator cuff tears are believed to have better healing potential than chronic tears due to less degenerative changes of the tendons. However, the histopathological condition of tendons from trauma-related tears is not well investigated. The purpose of this study was to explore specific histopathological features in tendons from acute trauma-related full-thickness rotator cuff tears and to compare them to findings in tendons from nontraumatic, chronic tears. Methods: In a prospective cohort study, 62 previously asymptomatic patients [14 women, median age 61 years (range 42–75)] with trauma-related full-thickness rotator cuff tears were consecutively included. Arthroscopic repair was performed within 30 (median, IQR 25–37) days after the injury. During surgery, tissue biopsies were harvested from the supraspinatus tendons in 53 (86%) of the patients. In addition, similar biopsies were harvested from 10 patients undergoing surgery for chronic tears without history of trauma. All tissue samples were examined by a well-experienced pathologist under light microscope. Tendon degeneration was determined using the Bonar score whereas immunostaining was used for proliferation (Ki67), inflammation (CD45), apoptosis (p53) and haemosiderin staining to study traces of bleeding. Results: The median (IQR) Bonar score for the acute trauma-related biopsies was 10.5 (7.5–14.5) compared to 11 (5–12.8) for the control group with no statistically significant difference between the groups. No statistically significant between-group difference was found for the inflammatory index whereas tendons from patients with trauma-related full-thickness rotator cuff tears had statistically significantly higher apoptosis [3.1 (0.5–8.9) vs. 0.1 (0–1.5), p = 0.003] and proliferation [4.0 (1.8–6.9) vs. 0.4 (0–2.0), p = 0.001) indices than those undergoing surgery for chronic tears. Positive haemosiderin staining was found in 34% of tissue samples from patients with trauma-related tears compared to 10% in the control group (n.s). Conclusion: This study suggests that there is no difference with regard to degenerative changes between supraspinatus tendons harvested from patients with acute, trauma-related rotator cuff tears and patients with nontraumatic, chronic tears. Level of evidence: II.
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| 25. |
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| 26. |
- Aagaard, Lise, et al.
(författare)
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Global Patterns of Adverse Drug Reactions Over a Decade Analyses of Spontaneous Reports to VigiBase (TM)
- 2012
-
Ingår i: Drug Safety. - : Adis. - 0114-5916 .- 1179-1942. ; 35:12, s. 1171-1182
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Tidskriftsartikel (refereegranskat)abstract
- Background: Although systems to collect information about suspected adverse drug reactions (ADRs) were established in many countries and by the WHO in the 1960s, few studies have examined reported ADRs related to national income. Objective: The aim of the study was to characterize ADRs reported to the WHO-ADR database, VigiBase (TM), and to relate data to national income. Methods: We analysed ADR reports submitted to VigiBase (TM) from 2000 to 2009 with respect to reporting rate, age and sex of patient, type, seriousness and medications. Reports were also analysed with respect to national income level, classified in accordance with the World Bank definition: low, lower-middle, upper-middle and high. Results: We analysed 1 359 067 ADR reports including 3 013 074 ADRs. Overall, 16% of reports were serious and 60% were reported for females. High-income countries had the highest ADR reporting rates (range 3-613 reports/million inhabitants/year) and low-income countries the lowest (range 0-21). Distribution of ADRs across income groups with respect to age group, seriousness and sex was non-significant. Overall, the majority of ADRs were reported for nervous system medications, followed by cardiovascular medicines. Low-income countries reported relatively more ADRs for antiinfectives for systemic use than high-income countries, and high-income countries reported more ADRs for antineoplastic and immunomodulating agents than lower-income groups. Conclusion: This study showed that high-income countries had the highest ADR reporting rates and low-income countries the lowest, with large variations across countries in each group. Significant differences in ADR reporting rates were only found for ADRs of the type skin and subcutaneous tissue disorders and for the therapeutic groups antiinfectives for systemic use and antineoplastic and immunomodulation agents. To strengthen ADR reporting rates, especially in low-income countries, more research is needed about the impact of organizational structures and economic resources of national pharmacovigilance centres and ADR reporting practices on the large variations in ADR reporting rates within income groups.
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| 27. |
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| 28. |
- Aagard Nielsen, Kurt, et al.
(författare)
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How to Learn Action Research
- 2006
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Ingår i: Action Research and Interactive Research. - Hamburg : Shaker Verlag. - 9789042302891 - 9042302895 ; , s. 389-398
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 29. |
- Aalberg, L, et al.
(författare)
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Development of a harmonised method for the profiling of amphetamines : II. Stability of impurities in organic solvents
- 2005
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Ingår i: Forensic Science International. - : Elsevier. - 0379-0738 .- 1872-6283. ; 149:03-Feb, s. 231-241
-
Tidskriftsartikel (refereegranskat)abstract
- The present study focused on the stability of 22 amphetamine impurities dissolved in six organic solvents: isooctane, toluene, ethanol, dichloromethane, ethyl acetate, and diethyl ether. The aim was to find the most inert, and thereby most suitable, solvent for amphetamine profiling. Mixtures of the impurities were prepared in the different solvents, and changes in the concentrations of the individual compounds over-time were monitored by gas chromatographic analysis after 0, 4, 12, 24, 48, and 96 h. Isooctane and toluene provided the most inert conditions, although, a few of the impurities were insufficiently stable in these two solvents. The present experiments were performed as a part of the development of a harmonised method for profiling of amphetamine. The results can be used to support the choice of organic solvents for sample preparation. They also provide information about the stability of the impurities that are found in profiles of illicit amphetamine. This is essential due to the fact, that unstable compounds can have a negative influence on the comparison of profiles.
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| 30. |
- Aalberg, Laura, et al.
(författare)
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Development of a harmonised method for the profiling of amphetamines : I. Synthesis of standards and compilation of analytical data
- 2005
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Ingår i: Forensic Science International. - : Elsevier BV. - 0379-0738 .- 1872-6283. ; 149:2-3, s. 219-229
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Tidskriftsartikel (refereegranskat)abstract
- Reference material was synthesised for 21 substances that are frequently present as synthetic impurities, i.e. by-products, in illicitly produced amphetamine. Each of these substances is a typical by-product for at least one of the three approaches most often used to synthesise amphetamine, namely, the Leuckart, the reductive amination of benzyl methyl ketone, and the nitrostyrene routes. A large body of data on the substances was recorded, including the following: mass spectra, ultraviolet spectra, Fourier transform infrared spectra, infrared spectra in gas phase, and 1H NMR and 13C NMR spectra. © 2004 Elsevier Ireland Ltd. All rights reserved.
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| 31. |
- Aalberse, Rob C, et al.
(författare)
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Further investigations of the IgE response to tetanus and diphtheria following covaccination with acellular rather than cellular Bordetella pertussis
- 2019
-
Ingår i: Pediatric Allergy and Immunology. - : Blackwell Publishing. - 0905-6157 .- 1399-3038. ; 30:8, s. 841-847
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundIt has previously been shown in an uncontrolled study that the IgE response to vaccine antigens is downregulated by co‐vaccination with cellular Bordetella pertussis vaccine.MethodsIn the present study, we compared in a controlled trial the humoral immune response to diphtheria toxoid (D) and tetanus toxoid (T) in relation to co‐vaccinated cellular or acellular B pertussis vaccine. IgE, IgG4, and IgG to D and T were analyzed at 2, 7, and 12 months of age in sera of children vaccinated with D and T (DT, N = 68), cellular (DTPw, N = 68), 2‐ or 5‐component acellular B pertussis vaccine (DTPa2, N = 64; DTPa5, N = 65).ResultsOne month after vaccination, D‐IgE was detected in 10% sera of DTPw‐vaccinated children, whereas vaccination in the absence of whole‐cell pertussis resulted in 50%‐60% IgE positivity. Six months after vaccination, the IgE antibody levels were found to be more persistent than the IgG antibodies. These diphtheria findings were mirrored by those for tetanus. Only minor differences between vaccine groups were found with regard to D‐IgG and T‐IgG. No immediate‐type allergic reactions were observed.ConclusionCellular (but not acellular) B pertussis vaccine downregulates IgE to co‐vaccinated antigens in infants. We assume that the absence of immediate‐type allergic reactions is due to the high levels of IgG antibodies competing with IgE antibodies.
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| 32. |
- Aalto, Anne, et al.
(författare)
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Brain magnetic resonance imaging does not contribute to the diagnosis of chronic neuroborreliosis
- 2007
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Ingår i: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 48:7, s. 755-762
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Tidskriftsartikel (refereegranskat)abstract
- Background: Borrelia infections, especially chronic neuroborreliosis ( NB), may cause considerable diagnostic problems. This diagnosis is based on symptoms and findings in the cerebrospinal fluid but is not always conclusive. Purpose: To evaluate brain magnetic resonance imaging ( MRI) in chronic NB, to compare the findings with healthy controls, and to correlate MRI findings with disease duration. Material and Methods: Sixteen well- characterized patients with chronic NB and 16 matched controls were examined in a 1.5T scanner with a standard head coil. T1- ( with and without gadolinium), T2-, and diffusion- weighted imaging plus fluid- attenuated inversion recovery ( FLAIR) imaging were used. Results: White matter lesions and lesions in the basal ganglia were seen in 12 patients and 10 controls ( no significant difference). Subependymal lesions were detected in patients down to the age of 25 and in the controls down to the age of 43. The number of lesions was correlated to age both in patients ( rho=0.83, P < 0.01) and in controls ( rho=0.61, P < 0.05), but not to the duration of disease. Most lesions were detected with FLAIR, but many also with T2- weighted imaging. Conclusion: A number of MRI findings were detected in patients with chronic NB, although the findings were unspecific when compared with matched controls and did not correlate with disease duration. However, subependymal lesions may constitute a potential finding in chronic NB.
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| 33. |
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| 34. |
- Aalto, K, et al.
(författare)
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Nerve growth factor in serum of children with systemic lupus erythematosus is correlated with disease activity
- 2002
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Ingår i: Cytokine. - : ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD. - 1043-4666 .- 1096-0023. ; 20:3, s. 136-139
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Tidskriftsartikel (refereegranskat)abstract
- Nerve growth factor (NGF) is a neurotrophic factor, which is expressed both in the nervous system and in peripheral organs. NGF is also present in mast cells, and in B- and T-lymphocytes, and may play a role in the immune cell development and differentiation. Various cytokines have been shown to affect NGF expression, and NGF is elevated in inflammation and in some autoimmune diseases. Here we have studied NGF concentrations in serum of pediatric patients with systemic lupus erythematosus (SLE) using a two-site enzyme-linked immunosorbent assay (ELISA). We have further correlated the levels of NGF to the inflammatory state of the disease. The mean value of serum NGF in SLE patients was significantly increased compared with controls (3346 vs 627 pg/ml). There was a correlation between the activity of SLE and the levels of NGF. The results show that NGF is elevated in childhood SLE and that the levels are correlated with disease activity. The present results suggest that NGF may play a role in the pathogenesis of SLE and may have a prognostic value in evaluating the course of the disease and in outlining the medication. (C) 2002 Elsevier Science Ltd. All rights reserved.
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| 35. |
- Aaltonen, Kristina, et al.
(författare)
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Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer
- 2014
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Ingår i: BMC Cancer. - : BioMed Central. - 1471-2407 .- 1471-2407. ; 14:794
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Tidskriftsartikel (refereegranskat)abstract
- Background: Resistance towards endocrine therapy is a great concern in breast cancer treatment and may partly be explained by the activation of compensatory signaling pathways. The aim of the present study was to investigate if the insulin-like growth factor-1 receptor (IGF1R) signaling pathway was activated or deregulated in breast cancer patients and to explore if any of the markers were prognostic, with or without adjuvant tamoxifen. This signaling pathway has been suggested to cause estrogen independent cell growth and thus contribute to resistance to endocrine treatment in estrogen receptor (ER) positive breast cancer. Methods: The protein expression of IGF1R, phosphorylated Mammalian Target of Rapamycin (p-mTOR) and phosphorylated S6 ribosomal protein (p-S6rp) were investigated by immunohistochemistry using tissue microarrays in two patient cohorts. Cohort I (N = 264) consisted of mainly postmenopausal women with stage II breast cancer treated with tamoxifen for 2 years irrespective of ER status. Cohort II (N = 206) consisted of mainly medically untreated, premenopausal patients with node-negative breast cancer. Distant disease-free survival (DDFS) at 5 years was used as end-point for survival analyses. Results: We found that lower IGF1R expression was associated with worse prognosis for tamoxifen treated, postmenopausal women (HR = 0.70, 95% CI = 0.52 - 0.94, p = 0.016). The effect was seen mainly in ER-negative patients where the prognostic effect was retained after adjustment for other prognostic markers (adjusted HR = 0.49, 95% CI = 0.29 - 0.82, p = 0.007). Expression of IGF1R was associated with ER positivity (p less than 0.001) in the same patient cohort. Conclusions: Our results support previous studies indicating that IGF1R positivity reflects a well differentiated tumor with low metastatic capacity. An association between lack of IGF1R expression and worse prognosis was mainly seen in the ER-negative part of Cohort I. The lack of co-activation of downstream markers (p-mTOR and p-S6rp) in the IGF1R pathway suggested that the prognostic effect was not due to complete activation of this pathway. Thus, no evidence could be found for a compensatory function of IGF1R signaling in the investigated cohorts.
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| 36. |
- Aamand Grabau, Dorthe, et al.
(författare)
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The prevalence of immunohistochemically determined oestrogen receptor positivity in primary breast cancer is dependent on the choice of antibody and method of heat-induced epitope retrieval - prognostic implications?
- 2013
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Ingår i: Acta Oncologica. - : Informa Healthcare. - 0284-186X .- 1651-226X. ; 52:8, s. 1657-1666
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Tidskriftsartikel (refereegranskat)abstract
- Background. Oestrogen receptor (ER) status is important for the choice of systemic treatment of breast cancer patients. However, most data from randomised trials on the effect of adjuvant endocrine therapy according to ER status are based on the cytosol methods. Comparisons with immunohistochemical methods have given similar results. The aim of the present study was to examine whether different ER antibodies and heat-induced epitope retrieval (HIER) methods influence the prevalence of ER-positivity in primary breast cancer. Material and methods. This study is based on patients included in a clinical trial designed to compare the effect of two years of adjuvant tamoxifen versus no adjuvant systemic treatment in premenopausal women. From 1986 to 1991, 564 patients from two study centres in Sweden were enrolled and randomised. Patients were randomised independently of ER status. In the present study, ER status was assessed on tissue microarrays with the three different ER antibody/HIER combinations: 1D5 in citrate pH 6 (n = 390), SP1 in Tris pH 9 (n = 390) and PharmDx in citrate pH 6 (n = 361). Results. At cut-offs of 1% and 10%, respectively, the prevalence of ER-positivity was higher with SP1 (75% and 72%) compared with 1D5 (68% and 66%) and PharmDx (66% and 62%). At these cut-offs, patients in the discordant groups (SP1-positive and 1D5-negative) seem to have a prognosis intermediate between those of the double-positive and double-negative groups. Comparison with the ER status determined by the cytosol-based methods in the discordant group also showed an intermediate pattern. The repeatability was good for all antibodies and cut-offs, with overall agreement andgt;= 93%. Conclusion. The present study shows that the choice of antibody and HIER method influences the prevalence of ER-positivity. We suggest that this be taken into consideration when choosing a cut-off for clinical decision making.
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| 37. |
- Aamir, Syed Ahmed, 1980-, et al.
(författare)
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A 1.2-V pseudo-differential OTA with common-mode feedforward in 65-nm CMOS
- 2010
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Ingår i: Proceedings of the 17th IEEE International Conference on Electronics, Circuits, and Systems. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 29-32
-
Konferensbidrag (refereegranskat)abstract
- In this work, we describe the implementation of a 1. 2-V pseudo-differential operational transconductance amplifier (OTA) with common-mode feedforward (CMFF) and inherent common-mode feedback (CMFB) in a 65-nm, digital CMOS process. The OTA architecture provides an inherent CMFB when cascaded OTA structures are utilized andthis work has studied a cascaded amplifier consisting of fourstages. Due to the low-gain using core 65-nm circuit devices, the overall gain must be distributed on all four stages to acquire a gain of more than 60 dB, while maintaining a-3-dB bandwidth of 200 MHz. To achieve high gain, we propose using a modified, positive-feedback, cross-coupled input differential stage. The modified OTA achieves a high output swing of ± 0.85 V due to only two stacked transistors, 88 dB DC gain and a third-order harmonic of -60 dB for 800 mVpp at 30 MHz. Further on, in a capacitive buffer configuration, we achieve a high slew rate of 1240 V/µS, -3-dB bandwidth of 509 MHz, signal-to-noise ratio of 63 dB while consuming 10.4 mW power.
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| 38. |
- Aamir, Syed Ahmed, 1980-, et al.
(författare)
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A 500-MHz low-voltage programmable gain amplifier for HD video in 65-nm CMOS
- 2010
-
Ingår i: Proceedings of 28th IEEE Norchip Conference., NORCHIP'10. - Tampere : www.ieee.org. - 9781424489718 - 9781424489725 ; , s. 1-4
-
Konferensbidrag (refereegranskat)abstract
- This work describes the implementation of a 1.2-V programmable gain amplifier (PGA) for high-definition (HD) video digitizers in a 65-nm digital CMOS process. The “pseudo” switched-capacitor (SC) PGA architecture buffers the video signal, without switching, during the active video. The SC circuitry is used for setup of DC operating point during horizontal and vertical blanking periods. Additionally, it compensates for the `sync-tip' of analog video signals to an equal blanking level for increased dynamic range to the digitizer following the PGA. The operational transconductance amplifier (OTA) employed as main amplifier in the PGA is a pseudo-differential, positive-feedback input stage architecture with a common-mode feedforward (CMFF) technique. The common-mode feedback (CMFB) is provided once two OTAs are cascaded. Schematic-level simulation results show that the OTA maintains a -3-dB bandwidth of 550 MHz, while keeping the distortion HD3 at -60 dB for a 30-MHz, 850 mVpp high definition video signal. The 88 dB DC gain is distributed among four OTA stages and the overall, combined PGA achieves a signal-to-noise ratio of 63 dB. Due to only two stacked transistors, it achieves high output swing of ±0.85 V, 1240 V/μs slew rate while consuming 10.4 mW power.
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| 39. |
- Aamodt, Ina Thon, et al.
(författare)
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Health Care Professionals Perceptions of Home Telemonitoring in Heart Failure Care: Cross-Sectional Survey
- 2019
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Ingår i: Journal of Medical Internet Research. - : JMIR PUBLICATIONS, INC. - 1438-8871. ; 21:2
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Tidskriftsartikel (refereegranskat)abstract
- Background: Noninvasive telemonitoring (TM) can be used in heart failure (HF) patients to perform early detection of decompensation at home, prevent unnecessary health care utilization, and decrease health care costs. However, the evidence is not sufficient to be part of HF guidelines for follow-up care, and we have no knowledge of how TM is used in the Nordic Baltic region. Objective: The aim of this study was to describe health care professionals (HCPs) perception of and presumed experience with noninvasive TM in daily HF patient care, perspectives of the relevance of and reasons for applying noninvasive TM, and barriers to the use of noninvasive TM. Methods: A cross-sectional survey was performed between September and December 2016 in Norway and Lithuania with physicians and nurses treating HF patients at either a hospital ward or an outpatient clinic. A total of 784 questionnaires were sent nationwide by postal mail to 107 hospitals. The questionnaire consisted of 43 items with close- and open-ended questions. In Norway, the response rate was 68.7% (226/329), with 57 of 60 hospitals participating, whereas the response rate was 68.1% (310/455) in Lithuania, with 41 of 47 hospitals participating. Responses to the closed questions were analyzed using descriptive statistics, and the open-ended questions were analyzed using summative content analysis. Results: This study showed that noninvasive TM is not part of the current daily clinical practice in Norway or Lithuania. A minority of HCPs responded to be familiar with noninvasive TM in HF care in Norway (48/226, 21.2%) and Lithuania (64/310, 20.6%). Approximately half of the HCPs in both countries perceived noninvasive TM to be relevant in follow-up of HF patients in Norway (131/226, 58.0%) and Lithuania (172/310, 55.5%). For physicians in both countries and nurses in Norway, the 3 most mentioned reasons for introducing noninvasive TM were to improve self-care, to reduce hospitalizations, and to provide high-quality care, whereas the Lithuanian nurses described ability to treat more patients and to reduce their workload as reasons for introducing noninvasive TM. The main barriers to implement noninvasive TM were lack of funding from health care authorities or the Territorial Patient Fund. Moreover, HCPs perceive that HF patients themselves could represent barriers because of their physical or mental condition in addition to a lack of internet access. Conclusions: HCPs in Norway and Lithuania are currently nonusers of TM in daily HF care. However, they perceive a future with TM to improve the quality of care for HF patients. Financial barriers and HF patients condition may have an impact on the use of TM, whereas sufficient funding from health care authorities and improved knowledge may encourage the more widespread use of TM in the Nordic Baltic region and beyond.
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| 40. |
- Aamodt, Ina Thon, et al.
(författare)
-
Informal Caregivers Experiences with Performing Telemonitoring in Heart Failure Care at Home-A Qualitative Study
- 2022
-
Ingår i: Healthcare. - : MDPI. - 2227-9032. ; 10:7
-
Tidskriftsartikel (refereegranskat)abstract
- Informal caregivers have an important role in caring for family members at home. Supporting persons with a chronic illness such as heart failure (HF) in managing their self-care is reported to be a challenge and telemonitoring has been suggested to be of support. Aim: to explore informal caregivers experiences with performing non-invasive telemonitoring to support persons with HF at home for 30 days following hospital discharge in Norway and Lithuania. Methods: A qualitative explorative study of informal caregivers performing non-invasive telemonitoring using lung-impedance measurements and short message service (SMS). Data was collected using semi-structured interviews with informal caregivers of persons with HF in NYHA class III-IV in Norway and Lithuania. Results: Nine interviews were conducted with informal caregivers of persons with HF who performed non-invasive telemonitoring at home. A sequential process of three categories emerged from the data: access to support, towards routinizing, and mastering non-invasive telemonitoring. Conclusion: Informal caregivers performed non-invasive telemonitoring for the first time in this study. Their experiences were of a sequential process that included access to support from health care professionals, establishing a routine together, and access to nurses or physicians in HF care as part of mastering. This study highlights involving informal caregivers and persons with HF together in the implementation and future research of telemonitoring in HF care.
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| 41. |
- Aamodt, Ina Thon, et al.
(författare)
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Self-Care Monitoring of Heart Failure Symptoms and Lung Impedance at Home Following Hospital Discharge: Longitudinal Study
- 2020
-
Ingår i: Journal of Medical Internet Research. - : JMIR PUBLICATIONS, INC. - 1438-8871. ; 22:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Self-care is key to the daily management of chronic heart failure (HF). After discharge from hospital, patients may struggle to recognize and respond to worsening HF symptoms. Failure to monitor and respond to HF symptoms may lead to unnecessary hospitalizations. Objective: This study aimed to (1) determine the feasibility of lung impedance measurements and a symptom diary to monitor HF symptoms daily at home for 30 days following hospital discharge and (2) determine daily changes in HF symptoms of pulmonary edema, lung impedance measurements, and if self-care behavior improves over time when patients use these self-care monitoring tools. Methods: This study used a prospective longitudinal design including patients from cardiology wards in 2 university hospitals-one in Norway and one in Lithuania. Data on HF symptoms and pulmonary edema were collected from 10 participants (mean age 64.5 years; 90% (9/10) male) with severe HF (New York Heart Association classes III and IV) who were discharged home after being hospitalized for an HF condition. HF symptoms were self-reported using the Memorial Symptom Assessment Scale for Heart Failure. Pulmonary edema was measured by participants using a noninvasive lung impedance monitor, the Cardio Set Edema Guard Monitor. Informal caregivers aided the participants with the noninvasive measurements. Results: The prevalence and burden of shortness of breath varied from participants experiencing them daily to never, whereas lung impedance measurements varied for individual participants and the group participants, as a whole. Self-care behavior score improved significantly (P=.007) from a median of 56 (IQR range 22-75) at discharge to a median of 81 (IQR range 72-98) 30 days later. Conclusions: Noninvasive measurement of lung impedance daily and the use of a symptom diary were feasible at home for 30 days in HF patients. Self-care behavior significantly improved after 30 days of using a symptom diary and measuring lung impedance at home. Further research is needed to determine if daily self-care monitoring of HF signs and symptoms, combined with daily lung impedance measurements, may reduce hospital readmissions.
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| 42. |
- Aamodt, Ina Thon, et al.
(författare)
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Tools to Support Self-Care Monitoring at Home: Perspectives of Patients with Heart Failure
- 2020
-
Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:23
-
Tidskriftsartikel (refereegranskat)abstract
- Self-care monitoring at home can be a challenge for patients with heart failure (HF). Tools that leverage information and communication technology (ICT), comprise medical devices, or have written material may support their efforts at home. The aim of this study was to describe HF patients experiences and their prioritization of tools that support, or could support, self-care monitoring at home. A descriptive qualitative design employing semi-structured interviews was used with HF patients living at home and attending an HF outpatient clinic in Norway. We used a deductive analysis approach, using the concept of self-care monitoring with ICT tools, paper-based tools, medical devices, and tools to consult with healthcare professionals (HCPs) as the categorization matrix. Nineteen HF patients with a mean age of 64 years participated. ICT tools are used by individual participants to identify changes in their HF symptoms, but are not available by healthcare services. Paper-based tools, medical devices, and face-to-face consultation with healthcare professionals are traditional tools that are available and used by individual participants. HF patients use traditional and ICT tools to support recognizing, identifying, and responding to HF symptoms at home, suggesting that they could be used if they are available and supplemented by in-person consultation with HCPs.
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| 43. |
- Aanaes, K, et al.
(författare)
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Extensive Endoscopic Image-Guided Sinus Surgery Decreases BPI-ANCA in Patients with Cystic Fibrosis
- 2012
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Ingår i: Scandinavian Journal of Immunology. - : Blackwell Publishing. - 0300-9475 .- 1365-3083. ; 76:6, s. 573-579
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Tidskriftsartikel (refereegranskat)abstract
- Antineutrophil cytoplasm autoantibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) are common in patients with cystic fibrosis (CF), and serum levels are correlated with lung colonization by Pseudomonas aeruginosa and the severity of lung damage. The production of BPI-ANCA may be due to the costimulation of BPI when mounting an immune response against P. aeruginosa. The effect of surgery aiming to eradicate bacteria and infected tissue on BPI-ANCA levels is sparsely described. A cohort of patients with CF were included: 53 patients having extensive image-guided sinus surgery (EIGSS) with topical postoperative antibiotic treatment, 131 non-operated controls and 36 who had double lung transplantation (LTX). In all 219 patients, serum samples before and after surgery or at similar intervals were analysed for IgG and IgA BPI-ANCA. The EIGSS group showed a highly significant decrease in both IgA and IgG BPI-ANCA levels compared with their own preoperative values and control group values (P andlt; 0.0010.02). The LTX patients also showed a highly significant decrease in both IgA and IgG BPI-ANCA levels (P andlt; 0.001). EIGSS and LTX decrease IgA and IgG BPI-ANCA levels in patients with CF, indicating that extensive removal of infected tissue influences the pathogenic process of autoantibody production. The results shown herein are in favour of applying EIGSS in selected patients with CF and for using BPI-ANCA as a surrogate marker for guiding further therapeutic interventions.
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| 44. |
- Aarao, J, et al.
(författare)
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Extended-domain-eigenfunction method (EDEM): a study of ill posedness and regularization
- 2013
-
Ingår i: Journal of Physics A. - : Institute of Physics. - 1751-8113 .- 1751-8121. ; 46:8
-
Tidskriftsartikel (refereegranskat)abstract
- The extended-domain-eigenfunction method (EDEM) proposed for solving elliptic boundary value problems on annular-like domains requires an inversion process. The procedure thus represents an ill-posed problem, whose numerical solution involves an ill-conditioned system of equations. In this paper, the ill-posed nature of EDEM is studied and numerical solutions based on regularization schemes are considered. It is shown that the EDEM solution methodology lends itself naturally to a formulation in terms of the well-known iterative Landweber method and the more general and faster converging semi-iterative regularization schemes. Theoretical details and numerical results of the regularization schemes are presented for the case of the two-dimensional Laplace operator on annular domains.
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| 45. |
- Aarao, J, et al.
(författare)
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Numerical implementation of the EDEM for modified Helmholtz BVPs on annular domains
- 2011
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Ingår i: JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS. - : Elsevier Science B.V., Amsterdam.. - 0377-0427. ; 235:5, s. 1342-1353
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Tidskriftsartikel (refereegranskat)abstract
- In a recent paper by the current authors a new methodology called the Extended-Domain-Eigenfunction-Method (EDEM) was proposed for solving elliptic boundary value problems on annular-like domains. In this paper we present and investigate one possible numerical algorithm to implement the EDEM. This algorithm is used to solve modified Helmholtz BVPs on annular-like domains. Two examples of annular-like domains are studied. The results and performance are compared with those of the well-known boundary element method (BEM). The high accuracy of the EDEM solutions and the superior efficiency of the EDEM over the BEM, make EDEM an excellent alternate candidate to use in the animation industry, where speed is a predominant requirement, and by the scientific community where accuracy is the paramount objective.
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| 46. |
- Aarao, J, et al.
(författare)
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The extended-domain-eigenfunction method for solving elliptic boundary value problems with annular domains
- 2010
-
Ingår i: JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL. - : Iop. - 1751-8113 .- 1751-8121. ; 43:18, s. 185202-
-
Tidskriftsartikel (refereegranskat)abstract
- Standard analytical solutions to elliptic boundary value problems on asymmetric domains are rarely, if ever, obtainable. In this paper, we propose a solution technique wherein we embed the original domain into one with simple boundaries where the classical eigenfunction solution approach can be used. The solution in the larger domain, when restricted to the original domain, is then the solution of the original boundary value problem. We call this the extended-domain-eigenfunction method. To illustrate the methods strength and scope, we apply it to Laplaces equation on an annular-like domain.
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| 47. |
- Aardal, Elisabeth, et al.
(författare)
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Cortisol in Saliva : Reference Ranges and Relation to Cortisol in Serum
- 1995
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Ingår i: European Journal of Clinical Chemistry and Clinical Biochemistry. - : Walter de Gruyter GmbH. - 0939-4974. ; 33, s. 927-932
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to establish morning and evening reference ranges for cortisol in saliva. Another objective was to compare the concentrations of the mainly free cortisol in saliva to those of total cortisol in serum as determined with a commercial radioimmunoassay. The concentrations were determined in matched samples of saliva and serum collected at 8am and 10pm from 197 healthy volunteers. The saliva samples were stable for at least 7 days at room temperature and for 9 months at —20 °C. Reference ranges, the central 95%, were estimated to 3.5—27.0 nmol/1 at 8 am and < 6.0 nmol/1 at 10 pm. The intra-assay coefficient of variation (CV) was below 5% and total CV below 10%. The relation between the cortisol concentrations in serum and saliva was nonlinear with r = 0.86 for serum concentrations < 450 nmol/1 and r = 0.44 for serum concentrations ^ 450 nmol/1. In conclusion, the satisfactory precision of the analysis and the simple non-invasive sampling procedure suggest that saliva may be used for cortisol measurements in situations where blood sampling is difficult to perform.
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| 48. |
- Aardal-Eriksson, Elisabeth, et al.
(författare)
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Iron depletion in blood donors - Have extended erythrocyte and reticulocyte parameters diagnostic utility?
- 2015
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Ingår i: Transfusion and apheresis science. - : PERGAMON-ELSEVIER SCIENCE LTD. - 1473-0502 .- 1878-1683. ; 53:1, s. 76-81
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Tidskriftsartikel (refereegranskat)abstract
- Background: Blood donation is associated with iron depletion, but donor iron status is not usually investigated, as such tests are cumbersome and costly. It would therefore be desirable to have simple, fast and inexpensive tests that give information on a donors risk of developing iron depletion. In a pilot study we investigated whether novel erythrocyte and reticulocyte parameters can serve this goal. Methods: In regular blood donors extended red cell parameters were measured using the Abbott CELL-DYN Sapphire hematology analyzer and conventional biochemical tests of iron status. Donors were compared with a regionally matched group of non-donating controls. Results: In the controls, the reference ranges of extended RBC parameters were well comparable to published data. Donors had significantly more microcytic RBC than controls (median 0.9 vs 0.6%), lower serum ferritin concentration (median 43 vs 91 mg/L) and higher soluble transferrin receptor/ferritin index (median 1.60 vs 1.27). Overall 18-28% of the donors were iron depleted. Moreover, 3.3% of donors had iron-restricted erythropoiesis. Microcytic RBC and reticulocyte mean cell hemoglobin content predicted iron depletion with 70% and 64% sensitivities and specificities of 72% and 78%, respectively. When combined these two parameters increased the sensitivity to 82%. Conclusions: Our results in Swedish blood donors confirm a high prevalence of iron depletion, despite iron supplementation used by about half of the donors. Microcytic RBC and MCHr appeared to be helpful in identifying iron-depleted donors, who might benefit from iron supplementation. We recommend larger prospective investigations in order to confirm and extend the findings of this pilot study. (C) 2015 Elsevier Ltd. All rights reserved.
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| 49. |
- Aardal-Eriksson, Elisabeth, et al.
(författare)
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Pre-trauma Salivary Cortisol Levels and General Health Ratings in Relation to Post-trauma Changes in Cortisol and Psychological Distress after UN-service in Bosnia
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: The psychobiology of post-traumatic distress is known to some extent, however the pre-trauma psychobiology is not. The aims of the present study were to relate pre- and post-trauma salivary cortisol levels and general health to post-traumatic distress in a Swedish UN-battalion in Bosnia.Methods: Salivary 8 AM and I 0 PM cortisol levels and "General Health Questionnaire" ratings were collected from 145 subjects before the six months' mission, at return and two and six months after mission. During follow-up, the ratings were extended by the "Impact of Events Scale" (IES) and "Post Traumatic Symptom Scale".Results: Low pre-trauma morning and evening salivary cortisol levels were statistically significantly related to high scores in all rating scales six months after mission and to increasing IES scores during follow-up. Low morning and high evening post-trauma salivary cortisol levels were related to high ratings of psychological distress six months after missionConclusions: Pre-trauma salivary cortisol levels seem to be related to posttrauma psychological distress, however not to the extent that salivary cortisol levels in a simple way could be used for predictive screening.
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| 50. |
- Aardal-Eriksson, Elisabeth, et al.
(författare)
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Salivary cortisol : an alternative to serum cortisol determinations in dynamic function tests
- 1998
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Ingår i: Clinical Chemistry and Laboratory Medicine. - 1434-6621 .- 1437-4331. ; 36:4, s. 215-222
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Tidskriftsartikel (refereegranskat)abstract
- Salivary cortisol was measured as an alternative to serum cortisol as a marker for adrenocortical function following insulin tolerance test, corticotropin-releasing-hormone stimulation and adreno-corticotrophic hormone stimulation. During insulin tolerance test and corticotropin-releasing-hormone stimulation adreno-corticotrophic hormone was also measured. The tests were performed on healthy control subjects as well as on patients under investigation for various disturbances in the hypothalamic-pituitary-adrenocortical axis (insulin tolerance test: 3 controls on two occasions and 14 patients; corticotropin-releasing-hormone stimulation: 4 controls and 18 patients; adreno-corticotrophic hormone stimulation: 6 controls and 10 patients). Five patients underwent both insulin tolerance test and corticotropin-releasing-hormone stimulation. Using criteria for adequate cortisol response in serum, the patients were classified as good or poor responders. In 42 of the 45 tests performed the same conclusion as to cortisol status was drawn when based on serum and salivary cortisol responses. In healthy subjects and good responders the mean cortisol relative increase was greater in saliva than in serum in all three tests (p < 0.05). Characteristic of the results for the insulin tolerance test was a significant initial mean decrease (p < 0.05), not found in serum, and the highest observed salivary cortisol value was delayed for at least 30 minutes compared to that in serum. Plasma adreno-corticotrophic hormone correlated significantly with the cortisol concentrations determined 15 minutes later in serum (r = 0.54–0.64) and in saliva (r = 0.76–0.85). The more pronounced cortisol response in saliva than in serum and its closer correlation with adreno-corticotrophic hormone offer advantages over serum cortisol, suggesting salivary cortisol measurement may be used as an alternative parameter in dynamic endocrine tets.
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