| 21. |
- Andersson-Engels, Stefan, et al.
(author)
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Deep-tissue optical imaging and photoactivation activities at biophotonics@tyndall
- 2016
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In: Frontiers in Optics, FiO 2016. - 2162-2701. - 9781943580194
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Conference paper (peer-reviewed)abstract
- Activities for deep tissue imaging and photoactivation will be presented. Wihin Biophotonics@Tyndall projects based on upconverting nanoparticles and ultrasound optical tomography will be pursued. Data from collaborative research will be given.
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| 22. |
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| 23. |
- Andersson-Engels, Stefan, et al.
(author)
-
Effects of Optical-constants On Time-gated Transillumination of Tissue and Tissue-like Media
- 1992
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In: Journal of Photochemistry and Photobiology, B: Biology. - 1011-1344. ; 16:2, s. 155-167
-
Journal article (peer-reviewed)abstract
- Light transillumination was used to study structures inside turbid media. Time-gated viewing was performed to suppress multiply-scattered light and thus improve spatial resolution. We demonstrate that, for the case of scattering-dominated attenuation (scattering coefficient much greater than the absorption coefficient), the detection of early transmitted light will be practically insensitive to variations in the absorption coefficient. This is an important observation for the development of time-gated optical mammography, since optical mammography using continuous-wave light is based on increased light absorption in the tumour region caused by the neovascularization surrounding a tumour. In order to detect tumours in time-gated viewing it is the scattering coefficient of the tumour that must be characteristic. The scattering coefficient is measured to be lower in the tumour region than in the surrounding breast tissue for one resected breast specimen.
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| 24. |
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| 25. |
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| 26. |
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| 27. |
- Andersson-Engels, Stefan, et al.
(author)
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Fluorescence Imaging and Point Measurements of Tissue - Applications To the Demarcation of Malignant-tumors and Atherosclerotic Lesions From Normal Tissue
- 1991
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In: Photochemistry and Photobiology. - 0031-8655. ; 53:6, s. 807-814
-
Journal article (peer-reviewed)abstract
- The possibilities of using laser-induced fluorescence for tissue diagnostics are discussed. The tissue types investigated are malignant tumors and atherosclerotic lesions. Studies with natural autofluorescence as well as with fluorescent tumor markers are included in this paper. Fluorescence emission and decay data are presented for some tissue chromophores contributing to tissue autofluorescence. Optical spectroscopic characteristics of fluorescent malignant tumor markers are analyzed and instrumental designs for clinical applications are discussed. Images recorded with a multicolor fluorescence imaging system developed in Lund are presented.
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| 28. |
- Andersson-Engels, Stefan, et al.
(author)
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Identification of brain tumours in rats using laser-induced fluorescence and haematoporphyrin derivative
- 1989
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In: Lasers in Medical Science. - 0268-8921. ; 4:4, s. 241-249
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Journal article (peer-reviewed)abstract
- Laser-induced fluorescence has been used for the identification of brain tumours in rats, which have been previously given tumour-seeking haematoporphyrin derivative. A pulsed nitrogen laser (λ=337 nm) was used in conjunction with an optical multichannel analyzer. For both inoculated RG-2 and TCVC rat-brain-tumour models, the blue autofluorescence was strongly reduced in the tumour compared with normal brain tissue, and at the same time the characteristic red-drug signal increased. The contrast between tumour and normal tissue was strongly enhanced by forming the ratio between the two signals. Implications for possible improvement of tumour delineation in brain tumour surgery are discussed.
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| 29. |
- Andersson-Engels, Stefan, et al.
(author)
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In vivo fluorescence imaging for tissue diagnostics
- 1997
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In: Physics in Medicine and Biology. - : IOP Publishing. - 1361-6560 .- 0031-9155. ; 42:5, s. 815-824
-
Journal article (peer-reviewed)abstract
- Non-invasive fluorescence imaging has the potential to provide in vivo diagnostic information for many clinical specialities. Techniques have been developed over the years for simple ocular observations following UV excitation to sophisticated spectroscopic imaging using advanced equipment. Much of the impetus for research on fluorescence imaging for tissue diagnostics has come from parallel developments in photodynamic therapy of malignant lesions with fluorescent photosensitizers. However, the fluorescence of endogenous molecules (tissue autofluorescence) also plays an important role in most applications. In this paper, the possibilities of imaging tissues using fluorescence spectroscopy as a mean of tissue characterization are discussed. The various imaging techniques for extracting diagnostic information suggested in the literature are reviewed. The development of exogenous fluorophores for this purpose is also presented. Finally, the present status of clinical evaluation and future directions are discussed.
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| 30. |
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